ID A0A2A3Y534_9MICC Unreviewed; 379 AA.
AC A0A2A3Y534;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE RecName: Full=Citrate synthase {ECO:0000256|PIRNR:PIRNR001369};
GN ORFNames=CIK74_17045 {ECO:0000313|EMBL:PCC31384.1};
OS Glutamicibacter sp. BW77.
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Micrococcaceae;
OC Glutamicibacter.
OX NCBI_TaxID=2024402 {ECO:0000313|EMBL:PCC31384.1, ECO:0000313|Proteomes:UP000218926};
RN [1] {ECO:0000313|EMBL:PCC31384.1, ECO:0000313|Proteomes:UP000218926}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BW77 {ECO:0000313|EMBL:PCC31384.1,
RC ECO:0000313|Proteomes:UP000218926};
RX PubMed=28644126;
RA Bonham K.S., Wolfe B.E., Dutton R.J.;
RT "Extensive horizontal gene transfer in cheese-associated bacteria.";
RL Elife 6:e22144-e22144(2017).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=acetyl-CoA + H2O + oxaloacetate = citrate + CoA + H(+);
CC Xref=Rhea:RHEA:16845, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:16452, ChEBI:CHEBI:16947, ChEBI:CHEBI:57287,
CC ChEBI:CHEBI:57288; EC=2.3.3.16;
CC Evidence={ECO:0000256|ARBA:ARBA00000308};
CC -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle.
CC {ECO:0000256|ARBA:ARBA00005163}.
CC -!- SIMILARITY: Belongs to the citrate synthase family.
CC {ECO:0000256|ARBA:ARBA00010566, ECO:0000256|PIRNR:PIRNR001369,
CC ECO:0000256|RuleBase:RU003406}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PCC31384.1}.
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DR EMBL; NRGT01000086; PCC31384.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2A3Y534; -.
DR OrthoDB; 9800864at2; -.
DR UniPathway; UPA00223; -.
DR Proteomes; UP000218926; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0036440; F:citrate synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniPathway.
DR Gene3D; 1.10.580.10; Citrate Synthase, domain 1; 1.
DR Gene3D; 1.10.230.10; Cytochrome P450-Terp, domain 2; 1.
DR InterPro; IPR011278; 2-MeCitrate/Citrate_synth_II.
DR InterPro; IPR016142; Citrate_synth-like_lrg_a-sub.
DR InterPro; IPR016143; Citrate_synth-like_sm_a-sub.
DR InterPro; IPR002020; Citrate_synthase.
DR InterPro; IPR019810; Citrate_synthase_AS.
DR InterPro; IPR024176; Citrate_synthase_bac-typ.
DR InterPro; IPR036969; Citrate_synthase_sf.
DR NCBIfam; TIGR01800; cit_synth_II; 1.
DR PANTHER; PTHR11739; CITRATE SYNTHASE; 1.
DR PANTHER; PTHR11739:SF4; CITRATE SYNTHASE, PEROXISOMAL; 1.
DR Pfam; PF00285; Citrate_synt; 1.
DR PIRSF; PIRSF001369; Citrate_synth; 1.
DR PRINTS; PR00143; CITRTSNTHASE.
DR SUPFAM; SSF48256; Citrate synthase; 1.
DR PROSITE; PS00480; CITRATE_SYNTHASE; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000218926};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PIRNR:PIRNR001369}.
FT ACT_SITE 271
FT /evidence="ECO:0000256|PIRSR:PIRSR001369-1"
FT ACT_SITE 322
FT /evidence="ECO:0000256|PIRSR:PIRSR001369-1"
SQ SEQUENCE 379 AA; 41649 MW; AEDFBF26DC782DC5 CRC64;
MSTTEDIKKG LAGVVVDYTA VSKVNPETNS LLYRGYPVQD LAASKSFEEV ALLLWTGELP
SESELTEFSA FERANRALDP RVKAAIDLLP TDCHPMDVGR TAVSVIGANH AEAENSSPEA
ELRKAKELFA AFPAVVAYDQ RRRRGQELVA PREDLDYSSN FLWMSFGEEA APEVVDAFRV
SMVLYAEHSF NASTFTARVI TSTLSDLHSA VTGAIGALKG PLHGGANEAV MHTFDEIGID
KNESRKDAAV RAKAWMEDAL AQKKKVMGFG HRVYKHGDSR VPTMKAALDK MIEHYGRSEM
LGLYDGLESA MDEAKAIKPN LDYPAGPTYH LMGFDTEMFT PIFIAARITG WTAHIFEQRA
SNALIRPLSA YNGPEQRAL
//
