ID A0A2A3YFC6_9MICO Unreviewed; 472 AA.
AC A0A2A3YFC6;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 16.
DE RecName: Full=alanine--tRNA ligase {ECO:0000256|ARBA:ARBA00013168};
DE EC=6.1.1.7 {ECO:0000256|ARBA:ARBA00013168};
GN ORFNames=CIK66_16195 {ECO:0000313|EMBL:PCC38030.1};
OS Brachybacterium alimentarium.
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Dermabacteraceae;
OC Brachybacterium.
OX NCBI_TaxID=47845 {ECO:0000313|EMBL:PCC38030.1, ECO:0000313|Proteomes:UP000218598};
RN [1] {ECO:0000313|EMBL:PCC38030.1, ECO:0000313|Proteomes:UP000218598}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=341_9 {ECO:0000313|EMBL:PCC38030.1,
RC ECO:0000313|Proteomes:UP000218598};
RX PubMed=28644126;
RA Bonham K.S., Wolfe B.E., Dutton R.J.;
RT "Extensive horizontal gene transfer in cheese-associated bacteria.";
RL Elife 6:e22144-e22144(2017).
CC -!- SIMILARITY: Belongs to the class-II aminoacyl-tRNA synthetase family.
CC {ECO:0000256|ARBA:ARBA00008226}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PCC38030.1}.
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DR EMBL; NRGR01000028; PCC38030.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2A3YFC6; -.
DR OrthoDB; 9803884at2; -.
DR Proteomes; UP000218598; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0004813; F:alanine-tRNA ligase activity; IEA:UniProtKB-EC.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0000049; F:tRNA binding; IEA:UniProtKB-KW.
DR GO; GO:0006419; P:alanyl-tRNA aminoacylation; IEA:InterPro.
DR CDD; cd00673; AlaRS_core; 1.
DR InterPro; IPR045864; aa-tRNA-synth_II/BPL/LPL.
DR InterPro; IPR002318; Ala-tRNA-lgiase_IIc.
DR InterPro; IPR018162; Ala-tRNA-ligase_IIc_anticod-bd.
DR InterPro; IPR018165; Ala-tRNA-synth_IIc_core.
DR InterPro; IPR018164; Ala-tRNA-synth_IIc_N.
DR PANTHER; PTHR11777:SF9; ALANINE--TRNA LIGASE, CYTOPLASMIC; 1.
DR PANTHER; PTHR11777; ALANYL-TRNA SYNTHETASE; 1.
DR Pfam; PF01411; tRNA-synt_2c; 1.
DR PRINTS; PR00980; TRNASYNTHALA.
DR SUPFAM; SSF55681; Class II aaRS and biotin synthetases; 1.
DR SUPFAM; SSF101353; Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS); 1.
DR PROSITE; PS50860; AA_TRNA_LIGASE_II_ALA; 1.
PE 3: Inferred from homology;
KW Aminoacyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00023146};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000218598};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884};
KW tRNA-binding {ECO:0000256|ARBA:ARBA00022555}.
FT DOMAIN 3..472
FT /note="Alanyl-transfer RNA synthetases family profile"
FT /evidence="ECO:0000259|PROSITE:PS50860"
SQ SEQUENCE 472 AA; 53390 MW; 07B6B567FDBC1A22 CRC64;
MPLKTDQIRT AYLHYFEERG HTLIPRAGLI PERDDTTLFT GSGMQPLMPY LLGAPHQDGM
RLADSQPAVR AQDIEDVGDN RHTTFFEMLG NWSLGDYFKT EQIRWFFDFL TRIVGLDPHR
LYVTAFAGDA QAGIPRDDEV VQIWQQVFAE HGIDAQVAVI GSQADGDARG IQAGERIFFY
GDEENWWSRG RGLAGTPIGD PCGPDSEVFY DFGPEHHNPT YGLAHPASES GRFMEIGNQV
FMQYQRQPGG SFTPLTHRNV DFGGGLERIA AAANNDPDVF QVSVLRPIIN HLEKLSGRSY
QDKTASMRVI ADHLRAAVFM TVDGVRPGNK ERGYVLRRLM RRAIRYAQDL GIQGSFLPTT
IPVITALYTR DYPELDEQYE TIVTVLEKEE RSFRRTLRKG LEELHRRGPA GMTGADVFTL
YDTFGFPTEL TVEESLRNGY ILSPSWCDEF GRIMQQQRAR SRPTITHPGH TR
//
