ID A0A2A4CNA4_9RHOB Unreviewed; 444 AA.
AC A0A2A4CNA4;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE RecName: Full=Zinc metalloprotease {ECO:0000256|RuleBase:RU362031};
DE EC=3.4.24.- {ECO:0000256|RuleBase:RU362031};
GN Name=rseP {ECO:0000313|EMBL:PCD75800.1};
GN ORFNames=CLN94_11610 {ECO:0000313|EMBL:PCD75800.1};
OS Pseudothioclava arenosa.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC Paracoccaceae; Pseudothioclava.
OX NCBI_TaxID=1795308 {ECO:0000313|EMBL:PCD75800.1, ECO:0000313|Proteomes:UP000243507};
RN [1] {ECO:0000313|EMBL:PCD75800.1, ECO:0000313|Proteomes:UP000243507}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CAU 1312 {ECO:0000313|EMBL:PCD75800.1,
RC ECO:0000313|Proteomes:UP000243507};
RA Liu Y., Shao Z.;
RT "A multilocus sequence analysis scheme for characterization of bacteria in
RT the genus Thioclava.";
RL Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947,
CC ECO:0000256|RuleBase:RU362031};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the peptidase M50B family.
CC {ECO:0000256|ARBA:ARBA00007931, ECO:0000256|RuleBase:RU362031}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PCD75800.1}.
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DR EMBL; NTJD01000009; PCD75800.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2A4CNA4; -.
DR OrthoDB; 9782003at2; -.
DR Proteomes; UP000243507; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00989; PDZ_metalloprotease; 1.
DR CDD; cd06163; S2P-M50_PDZ_RseP-like; 1.
DR Gene3D; 2.30.42.10; -; 2.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR041489; PDZ_6.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR004387; Pept_M50_Zn.
DR InterPro; IPR008915; Peptidase_M50.
DR NCBIfam; TIGR00054; RIP metalloprotease RseP; 1.
DR PANTHER; PTHR42837:SF2; MEMBRANE METALLOPROTEASE ARASP2, CHLOROPLASTIC-RELATED; 1.
DR PANTHER; PTHR42837; REGULATOR OF SIGMA-E PROTEASE RSEP; 1.
DR Pfam; PF17820; PDZ_6; 1.
DR Pfam; PF02163; Peptidase_M50; 1.
DR SMART; SM00228; PDZ; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 2.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU362031};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362031};
KW Metal-binding {ECO:0000256|RuleBase:RU362031};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049,
KW ECO:0000256|RuleBase:RU362031};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000313|EMBL:PCD75800.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000243507};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362031};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362031};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU362031}.
FT TRANSMEM 6..27
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362031"
FT TRANSMEM 111..139
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362031"
FT TRANSMEM 374..397
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362031"
FT TRANSMEM 418..439
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362031"
FT DOMAIN 200..272
FT /note="PDZ"
FT /evidence="ECO:0000259|SMART:SM00228"
SQ SEQUENCE 444 AA; 47223 MW; 07F94E7823F08D07 CRC64;
MEFLGGFADL LYTIVSFVIA LSVIVTVHEY GHYIIGRISG IKAEVFSLGF GPKLISRVDK
QGTRWQIAAI PLGGYVKFLG DANAASAGVD EGAMAVLSPE ERRHTMHGAP LWARAATVAA
GPVFNFILSI LVIAGLMMWS GTPTEKPAIA TLIELPEGTG DLRPGDQIIA IEGQETPDYD
TINTLVEKLP SQPTLTWRIE RDGVSQEITG PQLFPPVLVG VAPSSAAYDA GILPDDVIVS
IDGAPIWRFA DLQAAVRAAE GKPLALEIWS PSSGETRPVT LSARRTDLPV GDGVFETRWL
IGANGGFVFE PETRPTAISD ALIGGVRQTW GIVAQSISGL KAMILKQISS CNLSGALRIA
ESSAAAAKGG MPDFIWFIAV LSTAVGFLNL LPIPVLDGGH LMFHLWEGIT GKPPSDKVLN
ALMAMGLSLV LTLMLFGLWN DLFC
//
