ID A0A2A4E973_9MICO Unreviewed; 458 AA.
AC A0A2A4E973;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN ORFNames=AUC47_10095 {ECO:0000313|EMBL:PCE15868.1};
OS Microbacterium sp. SZ1.
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Microbacteriaceae;
OC Microbacterium.
OX NCBI_TaxID=1849736 {ECO:0000313|EMBL:PCE15868.1, ECO:0000313|Proteomes:UP000217958};
RN [1] {ECO:0000313|EMBL:PCE15868.1, ECO:0000313|Proteomes:UP000217958}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SZ1 {ECO:0000313|EMBL:PCE15868.1,
RC ECO:0000313|Proteomes:UP000217958};
RA Shamseldin A., Moawad H., Abd El-Rahim W.M., Sadowsky M.J.;
RL Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PCE15868.1}.
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DR EMBL; LPVV01000003; PCE15868.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2A4E973; -.
DR OrthoDB; 9786919at2; -.
DR Proteomes; UP000217958; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR CDD; cd06225; HAMP; 1.
DR CDD; cd00075; HATPase; 1.
DR CDD; cd00082; HisKA; 1.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 6.10.340.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR003660; HAMP_dom.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR003661; HisK_dim/P.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR PANTHER; PTHR45436:SF5; SENSOR HISTIDINE KINASE TRCS; 1.
DR PANTHER; PTHR45436; SENSOR HISTIDINE KINASE YKOH; 1.
DR Pfam; PF00672; HAMP; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF00512; HisKA; 1.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00304; HAMP; 1.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00388; HisKA; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF158472; HAMP domain-like; 1.
DR SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR PROSITE; PS50885; HAMP; 1.
DR PROSITE; PS50109; HIS_KIN; 1.
PE 4: Predicted;
KW Kinase {ECO:0000256|ARBA:ARBA00022777}; Membrane {ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Two-component regulatory system {ECO:0000256|ARBA:ARBA00023012}.
FT TRANSMEM 162..184
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 185..238
FT /note="HAMP"
FT /evidence="ECO:0000259|PROSITE:PS50885"
FT DOMAIN 246..456
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
SQ SEQUENCE 458 AA; 49368 MW; A0B140D9570221E2 CRC64;
MRRRLVVVFL VPLIAILMSL GGVTAWSATR SIQQTFYTEQ LGDLAYFVTS ARQALRSGAA
TVIDAEVRRF HEVYDIDVRV FDLTGAAWAA GDREGDVLSD EETARVGLAL SGRRAEAPAP
VFPWSIPESS LVEPVFDDGD VIGAVMVSAD TAAPRAEIVQ QVIVLSLVSV TTVGLGILLV
MQLARWVLSP VRRLDEAMIA IERGEMDARV AEDTGPPELR RMTRVFNGMA DEIERVMTRQ
QEFALNASHE LRNPLNALLL RVEHLSTGLG DEWRDDVEET REEGRRLVRI LETLLSLARG
GRGDTTVSAV DLIALAGRRA EAWQEVAGQR GISVVAPGGD PVMTVTDRTI VESALDAVID
NAVKYSTPDS VVVVAAQRDE NACRLTVRDQ GPGLTAEQAA AATDRFWRSD DRGDTPGSGL
GLAIATDLLR SLGAELLVDS PESGGLLVTL LLPDGADA
//
