ID A0A2A4EAH3_9MICO Unreviewed; 419 AA.
AC A0A2A4EAH3;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=Citrate synthase {ECO:0000256|PIRNR:PIRNR001369, ECO:0000256|RuleBase:RU003370};
GN ORFNames=AUC47_02390 {ECO:0000313|EMBL:PCE15043.1};
OS Microbacterium sp. SZ1.
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Microbacteriaceae;
OC Microbacterium.
OX NCBI_TaxID=1849736 {ECO:0000313|EMBL:PCE15043.1, ECO:0000313|Proteomes:UP000217958};
RN [1] {ECO:0000313|EMBL:PCE15043.1, ECO:0000313|Proteomes:UP000217958}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SZ1 {ECO:0000313|EMBL:PCE15043.1,
RC ECO:0000313|Proteomes:UP000217958};
RA Shamseldin A., Moawad H., Abd El-Rahim W.M., Sadowsky M.J.;
RL Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=acetyl-CoA + H2O + oxaloacetate = citrate + CoA + H(+);
CC Xref=Rhea:RHEA:16845, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:16452, ChEBI:CHEBI:16947, ChEBI:CHEBI:57287,
CC ChEBI:CHEBI:57288; EC=2.3.3.16;
CC Evidence={ECO:0000256|ARBA:ARBA00000308,
CC ECO:0000256|RuleBase:RU003370};
CC -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate
CC from oxaloacetate: step 1/2. {ECO:0000256|ARBA:ARBA00004751,
CC ECO:0000256|RuleBase:RU003370}.
CC -!- SIMILARITY: Belongs to the citrate synthase family.
CC {ECO:0000256|ARBA:ARBA00010566, ECO:0000256|PIRNR:PIRNR001369,
CC ECO:0000256|RuleBase:RU003406}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PCE15043.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; LPVV01000012; PCE15043.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2A4EAH3; -.
DR UniPathway; UPA00223; UER00717.
DR Proteomes; UP000217958; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0004108; F:citrate (Si)-synthase activity; IEA:InterPro.
DR GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniPathway.
DR CDD; cd06114; EcCS_like; 1.
DR Gene3D; 2.20.28.60; -; 1.
DR Gene3D; 1.10.580.10; Citrate Synthase, domain 1; 1.
DR Gene3D; 1.10.230.10; Cytochrome P450-Terp, domain 2; 1.
DR InterPro; IPR016142; Citrate_synth-like_lrg_a-sub.
DR InterPro; IPR016143; Citrate_synth-like_sm_a-sub.
DR InterPro; IPR002020; Citrate_synthase.
DR InterPro; IPR019810; Citrate_synthase_AS.
DR InterPro; IPR024176; Citrate_synthase_bac-typ.
DR InterPro; IPR036969; Citrate_synthase_sf.
DR InterPro; IPR010953; Citrate_synthase_typ-I.
DR NCBIfam; TIGR01798; cit_synth_I; 1.
DR PANTHER; PTHR42871; CITRATE SYNTHASE; 1.
DR PANTHER; PTHR42871:SF1; CITRATE SYNTHASE; 1.
DR Pfam; PF00285; Citrate_synt; 1.
DR PIRSF; PIRSF001369; Citrate_synth; 1.
DR PRINTS; PR00143; CITRTSNTHASE.
DR SUPFAM; SSF48256; Citrate synthase; 1.
DR PROSITE; PS00480; CITRATE_SYNTHASE; 1.
PE 3: Inferred from homology;
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PIRNR:PIRNR001369};
KW Tricarboxylic acid cycle {ECO:0000256|ARBA:ARBA00022532,
KW ECO:0000256|RuleBase:RU003370}.
FT ACT_SITE 300
FT /evidence="ECO:0000256|PIRSR:PIRSR001369-1"
FT ACT_SITE 357
FT /evidence="ECO:0000256|PIRSR:PIRSR001369-1"
SQ SEQUENCE 419 AA; 46616 MW; D20E08D177EC944D CRC64;
MTIGETTAEF PVVRGTAGHD SIDFSTLTRQ TGYTGLDYGF VNTASTKSEI TFIDGDKGIL
RYRGYPIEQL AGKTTYLEVA WLLIYGELPS AAELAEFDEK IRRHTLLHED LKRFFSALPH
TAHPMSVLSS AVAALSTYYE GQTDPHNPEH VELNMVRMLA KLPVIAAYAH KKSVGQAFLY
PDNSLGFVEN FLKLNFGVNS EPYEINPVMS KALELLLILH EDHEQNASTS TVRLVGSTGA
NQFASISAGI QALSGPLHGG ANEAVLTMLG QIRDSGQSVS RFVERVKNKE EGVKLMGFGH
RVYKNYDPRA KLVKEAAGEV LAELGVTDPL LDLAQELEEI ALADDYFKER RLYPNVDFYT
GVIYKAMGFP TRMFTVLFAI GRLPGWLAQW RELQLDPQTK IGRPQQLYTG SVERTFQTR
//