ID A0A2A4G4P6_9FLAO Unreviewed; 730 AA.
AC A0A2A4G4P6;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE SubName: Full=Acylase {ECO:0000313|EMBL:PCE62695.1};
GN ORFNames=B7P33_15480 {ECO:0000313|EMBL:PCE62695.1};
OS Sediminicola luteus.
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae; Sediminicola.
OX NCBI_TaxID=319238 {ECO:0000313|EMBL:PCE62695.1, ECO:0000313|Proteomes:UP000219559};
RN [1] {ECO:0000313|EMBL:PCE62695.1, ECO:0000313|Proteomes:UP000219559}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HQA918 {ECO:0000313|EMBL:PCE62695.1,
RC ECO:0000313|Proteomes:UP000219559};
RA Chen L.;
RT "A new member of the family Flavobacteriaceae isolated from ascidians.";
RL Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC Evidence={ECO:0000256|PIRSR:PIRSR001227-2};
CC Note=Binds 1 Ca(2+) ion per dimer. {ECO:0000256|PIRSR:PIRSR001227-2};
CC -!- SIMILARITY: Belongs to the peptidase S45 family.
CC {ECO:0000256|ARBA:ARBA00006586}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PCE62695.1}.
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DR EMBL; NBWU01000007; PCE62695.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2A4G4P6; -.
DR OrthoDB; 9759796at2; -.
DR Proteomes; UP000219559; Unassembled WGS sequence.
DR GO; GO:0016811; F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0017000; P:antibiotic biosynthetic process; IEA:InterPro.
DR CDD; cd01936; Ntn_CA; 1.
DR Gene3D; 1.10.1400.10; -; 1.
DR Gene3D; 2.30.120.10; -; 1.
DR Gene3D; 3.60.20.10; Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1; 1.
DR Gene3D; 1.10.439.10; Penicillin Amidohydrolase, domain 1; 1.
DR InterPro; IPR029055; Ntn_hydrolases_N.
DR InterPro; IPR014395; Pen/GL7ACA/AHL_acylase.
DR InterPro; IPR043147; Penicillin_amidase_A-knob.
DR InterPro; IPR023343; Penicillin_amidase_dom1.
DR InterPro; IPR043146; Penicillin_amidase_N_B-knob.
DR InterPro; IPR002692; S45.
DR PANTHER; PTHR34218:SF4; ACYL-HOMOSERINE LACTONE ACYLASE QUIP; 1.
DR PANTHER; PTHR34218; PEPTIDASE S45 PENICILLIN AMIDASE; 1.
DR Pfam; PF01804; Penicil_amidase; 1.
DR PIRSF; PIRSF001227; Pen_acylase; 2.
DR SUPFAM; SSF56235; N-terminal nucleophile aminohydrolases (Ntn hydrolases); 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|PIRSR:PIRSR001227-2};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR001227-2};
KW Reference proteome {ECO:0000313|Proteomes:UP000219559};
KW Signal {ECO:0000256|SAM:SignalP}; Zymogen {ECO:0000256|ARBA:ARBA00023145}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..730
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5012765662"
FT ACT_SITE 202
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PIRSR:PIRSR001227-1"
FT BINDING 272
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR001227-2"
FT BINDING 275
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR001227-2"
SQ SEQUENCE 730 AA; 82903 MW; D1847BDD5674E4D2 CRC64;
MKAYLSFFIV FLLLIGCKEQ TASDEVAQWE AQAENVTIVR DDYGVPHVYG KTDADAVFGM
LYAQCEDDFN RVEQNYIWAT GRLAEVEGEE AIYSDLRAKL FMTEAEAKAN YEKSPPWLKD
LCDAFADGIN YYLYTHPEVK PRLFTRFEPW MPMYFSEGSI GGDIERISIE KIKAFYENGA
ALPEAQKVAL QTELENQEPA GSNGIAISGD LTASGNTLLL INPHTSFYFR GEMHMVSEEG
LNAYGAVTWG QFFIYQGFNE KTGWMHTSTY TDVMDEFMET VVEDEDGLFY LYGDDTREVA
QSETTIKYKT ENGMAEKTFP LYHTHHGPIT HMEQNQWVAS AMMWEPVKAL EQSFVRTKQT
GYKGFREMMD IRTNSSNNTV YADAEGNIAY FHGNFVPVRD TLYNYRKPVD GSNPATDWKG
LHTVDENILV LNPENGWIQN CNSTPYTSAL ENSPKRSDYP KYMSLDRENF RGVHAIELLT
GRSGYTLDNL IELAHDPYLP AFAALIPGLL EAYRNAAEKD ADLDKAMDIL ADWDFKTDTE
SVAMTLAHFY GTRYWQEGKR PEAASHMQSI IYFGSESPEM ERLTIFKKVM AQLEADFGTW
EMPWGEVHRY QRLNGDIRQA FNDDKPSKAV GYASGRWGAL AAYGARYHND TKKIYGTRGN
SFVGVVEFGE KVKAKTILAG GQSGNPDSPH FDDQTDAYIS HKFKEVPFYK EDVLQRAKRT
YRPGEAFGSD
//