ID A0A2A4I5F6_9SPHN Unreviewed; 556 AA.
AC A0A2A4I5F6;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 16.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN ORFNames=COA07_16870 {ECO:0000313|EMBL:PCG13023.1};
OS Sphingomonas adhaesiva.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Sphingomonadales;
OC Sphingomonadaceae; Sphingomonas.
OX NCBI_TaxID=28212 {ECO:0000313|EMBL:PCG13023.1, ECO:0000313|Proteomes:UP000218323};
RN [1] {ECO:0000313|EMBL:PCG13023.1, ECO:0000313|Proteomes:UP000218323}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 7418 {ECO:0000313|EMBL:PCG13023.1,
RC ECO:0000313|Proteomes:UP000218323};
RA Feng G., Zhu H.;
RT "Sphingomonas adhaesiva DSM 7418, whole genome shotgun sequence.";
RL Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PCG13023.1}.
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DR EMBL; NWVC01000015; PCG13023.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2A4I5F6; -.
DR Proteomes; UP000218323; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR003356; DNA_methylase_A-5.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR33841; DNA METHYLTRANSFERASE YEEA-RELATED; 1.
DR PANTHER; PTHR33841:SF5; TYPE II METHYLTRANSFERASE M.HINDII; 1.
DR Pfam; PF02384; N6_Mtase; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:PCG13023.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000218323};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:PCG13023.1}.
FT DOMAIN 13..195
FT /note="DNA methylase adenine-specific"
FT /evidence="ECO:0000259|Pfam:PF02384"
SQ SEQUENCE 556 AA; 60377 MW; 307C5268047A12EB CRC64;
MKGSDDVDTP ALRKARGAFF TPPALAHFLS EWAIRSSADT VLEPSCGDAA FLLPAVDRLR
ALGAKADMPG QLHGVEIHDA SATAANTRLA AHGASARIAI GDFFDEGPPP SKYDAVIGNP
PYVRYQQFSG DARAKSLQAA LAQGVRLTGL ASSWAAFTIH ASHFLKEDGR LGLVLPAELL
TVNYASQVRR FLLDRFAKVR LVLFEELVFP DVLEEVVLLL AEGSGGAPSF EVYQARNLND
LERMCSDSWV GYAPAGDQKW TPALLPAAAL DVYARLTDDA GFSTLLGGWG ETYLGAVTGN
NDYFSLTRAE VAKLKLDQSE LLPISPPGSK HLRGLTFGSA AWESLAKEGK RCFLFAPGPK
PSAAARAYIA KGEKEGVHLT YKCRNRTPWW RVPLVERPDL LFTYMNHDRP RLITNDAETQ
FLNSLYGVKL NDAVRAIGRE LLPLVCLNSA TLLGAEVVGR AYGGGMLKHE PREADLLPVP
SAATLEAVAD ELRAIRPQIG RALRGAKPQR AIDLVDTILL ERHLGLSPLE VGGLRGARDL
LFQRRVTRSR SERATN
//
