ID A0A2A4J2W6_HELVI Unreviewed; 2162 AA.
AC A0A2A4J2W6;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:PCG65733.1};
GN ORFNames=B5V51_8757 {ECO:0000313|EMBL:PCG65733.1};
OS Heliothis virescens (Tobacco budworm moth).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Noctuoidea;
OC Noctuidae; Heliothinae; Heliothis.
OX NCBI_TaxID=7102 {ECO:0000313|EMBL:PCG65733.1, ECO:0000313|Proteomes:UP000218220};
RN [1] {ECO:0000313|EMBL:PCG65733.1, ECO:0000313|Proteomes:UP000218220}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HvINT- {ECO:0000313|EMBL:PCG65733.1};
RC TISSUE=Whole body {ECO:0000313|EMBL:PCG65733.1};
RA Fritz M.L., Deyonke A.M., Papanicolaou A., Micinski S., Westbrook J.,
RA Gould F.;
RT "Contemporary evolution of a Lepidopteran species, Heliothis virescens, in
RT response to modern agricultural practices.";
RL Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PCG65733.1}.
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DR EMBL; NWSH01003873; PCG65733.1; -; Genomic_DNA.
DR UniPathway; UPA00094; -.
DR Proteomes; UP000218220; Unassembled WGS sequence.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd05195; enoyl_red; 1.
DR CDD; cd08954; KR_1_FAS_SDR_x; 1.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.30.70.3290; -; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 2.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR013149; ADH-like_C.
DR InterPro; IPR049391; FAS_pseudo-KR.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR020843; PKS_ER.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF23; FATTY ACID SYNTHASE 3; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF00107; ADH_zinc_N; 1.
DR Pfam; PF21149; FAS_pseudo-KR; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF08659; KR; 1.
DR Pfam; PF00550; PP-binding; 1.
DR SMART; SM00827; PKS_AT; 1.
DR SMART; SM00829; PKS_ER; 1.
DR SMART; SM00822; PKS_KR; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SMART; SM00823; PKS_PP; 1.
DR SUPFAM; SSF47336; ACP-like; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS50075; CARRIER; 1.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 1.
PE 4: Predicted;
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000218220};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 23..428
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 2057..2134
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2135..2162
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2162 AA; 238888 MW; 7152B2C4809492D4 CRC64;
MAPTTIAEDR LTSGHRLSHP PPGDEVLISG VSGYFPDSDS VNHLQENLFN KVDLISGDAR
RWKLAHPEIP QRTGKINNVN KFDASFFGVH YKQAHTMDPM CRILLEKAYE AVIDAGVNPK
ELRDTKTGVF VGACFSESEK TWFYEKMQVN GFGITGCSRA MLANRISYWL GVTGPSYTVD
SACSSSLYAL EHAFRAIRDG HCDAAIVGGS NLCLHPYVSL QFSRLGVLSP DGRCKSFDNS
ANGYARSEAI VVVFLQKAKD SRRVYAQLLH AKTNCDGYKE QGITYPAGHI QKLLLSEFYE
ECSIPPSILE FVEAHGTGTR VGDPEELLAI DEIFCTGRKA PLRIGSIKSN LGHSEPASGL
CSIAKMCIAY STGYLPPNLN YNVPREGVAA LAENRLQVVT DKTPWGRGMS GVNSFGFGGA
NAHALLKNVA RDKVNNGIPF DDLPRLVCVS GRTESAVARI LDDLESRTVD AELVRLYHAI
HDDDIAGHVV RGYTLLGSTP TKSVSLAREI QYFSGVRRPV WFVYSGMGSQ WAGMGKELMR
IPVFAAAIEK CHKALEPKGV NLTKIITDPD PKIYDNILNS FIGIAAVQIG LTDVLKTIGV
EPDYIIGHSV GELGCAYADG CFTAEEMILS AYSRGLASIE TPFIKGSMAA VGLGYNQIKS
MCPPEIEVAC HNGPDSSTIS GPADIMKVFV AKLSSQGIFA KEVPCSNIAY HSRYISQAGP
TLLKYLKQVI KDPKPRSEKW VSTSLPQAQW KDAKAALSSA EYHTNNLLSP VLFEETARLI
HPNAITIEIA PHGLLQAILR RSLKKDVINI ALTQRNHKDN VQVLFTAFGK LYESGLNPHL
ANIYPHVPFP VSQGTPMISH LVEWEHSEDW YVTSYKAQEK MKSGERTIRM SIVDEDCEYM
AGHVVDGRNL YPATGYLVLV WETLGMMMGE LFTEVSVVFE NVRFQRATNI PKEGNLEFII
MIQKGSGNFE IVESGASIVT GRIYAKKNVG QDYRVIPSLP EVSGPNIKHM LTKDFYKELR
LRGYQYSGLF RGVLGCNVEG TRGRLAWVNN WVTFMDCMLQ MKIIGQDTRG LFVPTRIEKL
SIDANMHYNA ISKMNPDSTK NSFEIRVYPD VDVIRGLFVP TRIEKLSIDA NMHYNAISKM
NPDSTKNSFE IRVYPDVDVI RAGGVEVRGL HATPITKRLP LGVPVLEKNE FIANFGKSKM
KLEDILRANI QLVLENIQTY KVKSIELVDE EYKKNEIEPI LETVGEMLGD LPLVQAELLM
ISEEPIEVSS NITVENKKLS GESNTILFIG ANLLSRPEVL QSAVGTLRDK CFLISREKVR
PNPKDYSDKY DIVTIHDTGV EYLVLFRKRV GARPAKFVRI LAADLEFSWI DKVKEELKEG
QKVVLYTQDE PINGLLGLVN CLRKEPGGEV VYGLLISDPS APAFNPDLEF YEEQLDKDLA
INIYQDGQWG TYRHLLLGDL ETVRANHAYV NTLTIGDLSS LSWVEGPIRE NHVFKSKEKV
LVSVYCAALN FRDVMTATGR VTVDAVARGR LAQECVQGFE IVGKTPNGSR VMGMIRNRGM
ANLAEGDKAL LWAIPDEWSF EEAATVPVAY GTVYYSMVMV GQIKHGESIL IHAGSGGVGQ
AAINVALHYG CEVFTTVGTA EKRAFIKKLF PQLKDSHIGN SRDASFEDMI RRETNGRGVD
MVLNSLSDEK LQASVRCLAY RGRFLEIGKF DISNNTPIGM YFFLKETSFH GIMLDYIFDQ
TYAFRKRLQD LLLSGIENGA VRPLTYCTFE AKEVETAFRY MAAGKHIGKV IVKIRDEERS
NRPVRPVVTP IQAVPRYICH EDHVYIVAGG LGGFGLELAD WLIMRGGRKI LLTSRRGVTN
GYQSSRLRAW ASYGADVQIS THDITTEEGC EAMLQQALKM GPVDAIFNLA VVLRDSIFQN
QTPETFKTSY GPKALATIYL DKLSRKLCPG LKDFVIFSSV SCGRGNAGQT NYGLSNSVME
RICEWRKKLG LPALAVQWGA VGDVGLVADM QDDDVQLEIG GTLQQRISSC LSALDKFMKQ
DAAIVSSIVV AEKKAGGSGC GNIVDAVAQI MGIKDLKTVS QQVSLAELGM DSMMAVEIKQ
TLEREFEIFL TAQDIRTLTF ARLVELTAQR EAAASTSASR PVNVEGAAAR SRTQGRDLGP
DG
//
