ID A0A2A4J4T9_HELVI Unreviewed; 1312 AA.
AC A0A2A4J4T9;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=DH domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=B5V51_7676 {ECO:0000313|EMBL:PCG66450.1};
OS Heliothis virescens (Tobacco budworm moth).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Noctuoidea;
OC Noctuidae; Heliothinae; Heliothis.
OX NCBI_TaxID=7102 {ECO:0000313|EMBL:PCG66450.1, ECO:0000313|Proteomes:UP000218220};
RN [1] {ECO:0000313|EMBL:PCG66450.1, ECO:0000313|Proteomes:UP000218220}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HvINT- {ECO:0000313|EMBL:PCG66450.1};
RC TISSUE=Whole body {ECO:0000313|EMBL:PCG66450.1};
RA Fritz M.L., Deyonke A.M., Papanicolaou A., Micinski S., Westbrook J.,
RA Gould F.;
RT "Contemporary evolution of a Lepidopteran species, Heliothis virescens, in
RT response to modern agricultural practices.";
RL Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PCG66450.1}.
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DR EMBL; NWSH01003367; PCG66450.1; -; Genomic_DNA.
DR STRING; 7102.A0A2A4J4T9; -.
DR Proteomes; UP000218220; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd20815; C1_p190RhoGEF-like; 1.
DR CDD; cd15789; PH_ARHGEF2_18_like; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR041020; PH_16.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR13944; AGAP007712-PA; 1.
DR PANTHER; PTHR13944:SF21; CYSTS, ISOFORM C; 1.
DR Pfam; PF17838; PH_16; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000218220}.
FT DOMAIN 495..684
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 725..828
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 1..68
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 122..205
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 258..287
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 388..448
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 996..1020
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1138..1190
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1228..1299
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..26
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 27..42
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 139..154
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 189..205
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 263..287
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 390..425
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 426..442
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1005..1020
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1138..1160
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1175..1189
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1248..1283
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1312 AA; 144484 MW; B7FB32EFAC781ECF CRC64;
MEPTAATMNL QPLENIFSSD EGGGSSDSRS DSSEDEVTEH VTRSTPPPDM AAARAQVPTI
SVTPHSPGLL EDSLQQLRRL HAAVQRMRTA PLPLLATGTS RLSTSCPSLC KDGVVEADCS
SPTHLDFYPQ SRKGSGESRQ WGLWERRDEG RRSSWAALEP GPRTHDTHRQ RNALNGHSAS
LSSMESEGEV PRPVRHSTHS LNDNDLAKDF EKVTAALRAG GVVPGSGVVA PVEGARLAAR
LPLQKSVSTP SIVAAVQPHL TQPPPNVGGT AASDSESDDA SAATVGATQP TRLSTTQDHL
GLHRLTFLEQ AAFDHHAEKR RKRGSLFFRK KKDKSRKTAH AWSAACSGGD CDWCGRALAD
KPALYCDNCT KTVHQNVCKD YFDCNKPKPS KTSVAKSLSA NSGKSSKRSS VSSQSQSTNS
TSHIYNDDKD GSDHKHDQSN ASDDAGVSEW PEVYLTPEQL GDEAIRLGLG ACEPDTWAAG
APKGLAKQLG DRETKRQEHI YELILTEKHH CLTIRLMQKM FAEGMVRGAG VSAAQAARMF
PRVDELWALH AALLGRLRAR QRLAPHVATV ADILADTFAP PAHHKLKAAY GEFCSRHRDA
VEVFKECCTR EPRLSRFIRK CQQNPLLRKK GVPECVLFVA QRLTKYPLLL EPLLKTAGDD
VAERELLQKA LCGVKEILVD VDNQVAAKER EDRKLEIYHR IDAKSFANFR GRKFKKSDIL
QGNRSLKFEG VATLMQGRSK MQTLLVIVLT DVLFFLHDNN NKYTFFTPDN KTGVVSLVKL
LVREKAGAEG RGLYLICSGP TEPEMFELRV HRPKDIQTWI QAIRAVVQSC PEEVEESEVG
ATAPSAEERQ RQLDARHENI RLITEALRSK DREHATLLEE KMALQMKLVG ITDETWLTLP
HSGSSTAFPG LVFPDYVRLA APSADKYALW QDVCKVVTDA LEASSMPWQC GGSLGRSTSS
AGERHSVAYE SPALPRRADT FAGFDANRHR GVTLRMSTDT PTEGGEPEAE PKQPEGDRAE
LSGEAVLKLQ HAIYTLTCIV WQQMTTIHSL EAQVSAWRWQ GGGAARPDWS DAQLEELRHA
QARLTRDRAA FDAQRQADHA ALAQERQQLQ AARQELAEQQ KDVEQQRERL FRQLERLQQH
AGGSQEEIAS VGTLSPDSSV SDTTRRKEPK WRNNRGSTGS ESSVSACSVR SGVLPPPQLL
SAQNETRATV AASNISQMVK QQLPLKLASG KSQQPPPGYH RLHESPSEHQ NQGLVIHHTR
TGSSPAPLPS QQQINNKATR TNTYPKLPDK FRVRSPDRSA VAAPAEEEVI FF
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