ID A0A2A4J6H2_HELVI Unreviewed; 822 AA.
AC A0A2A4J6H2;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE RecName: Full=Protein HIRA {ECO:0000256|RuleBase:RU364014};
DE Flags: Fragment;
GN ORFNames=B5V51_6832 {ECO:0000313|EMBL:PCG67124.1};
OS Heliothis virescens (Tobacco budworm moth).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Noctuoidea;
OC Noctuidae; Heliothinae; Heliothis.
OX NCBI_TaxID=7102 {ECO:0000313|EMBL:PCG67124.1, ECO:0000313|Proteomes:UP000218220};
RN [1] {ECO:0000313|EMBL:PCG67124.1, ECO:0000313|Proteomes:UP000218220}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HvINT- {ECO:0000313|EMBL:PCG67124.1};
RC TISSUE=Whole body {ECO:0000313|EMBL:PCG67124.1};
RA Fritz M.L., Deyonke A.M., Papanicolaou A., Micinski S., Westbrook J.,
RA Gould F.;
RT "Contemporary evolution of a Lepidopteran species, Heliothis virescens, in
RT response to modern agricultural practices.";
RL Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Required for replication-independent chromatin assembly and
CC for the periodic repression of histone gene transcription during the
CC cell cycle. {ECO:0000256|RuleBase:RU364014}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU364014}.
CC -!- SIMILARITY: Belongs to the WD repeat HIR1 family.
CC {ECO:0000256|ARBA:ARBA00007306, ECO:0000256|RuleBase:RU364014}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PCG67124.1}.
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DR EMBL; NWSH01003002; PCG67124.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2A4J6H2; -.
DR STRING; 7102.A0A2A4J6H2; -.
DR Proteomes; UP000218220; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006338; P:chromatin remodeling; IEA:InterPro.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 3.
DR InterPro; IPR031120; HIR1-like.
DR InterPro; IPR011494; HIRA-like_C.
DR InterPro; IPR019015; HIRA_B_motif.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR13831; MEMBER OF THE HIR1 FAMILY OF WD-REPEAT PROTEINS; 1.
DR PANTHER; PTHR13831:SF0; PROTEIN HIRA; 1.
DR Pfam; PF07569; Hira; 1.
DR Pfam; PF09453; HIRA_B; 1.
DR Pfam; PF00400; WD40; 5.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; WD40 repeat-like; 2.
DR PROSITE; PS50082; WD_REPEATS_2; 3.
DR PROSITE; PS50294; WD_REPEATS_REGION; 3.
PE 3: Inferred from homology;
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853,
KW ECO:0000256|RuleBase:RU364014}; Nucleus {ECO:0000256|RuleBase:RU364014};
KW Reference proteome {ECO:0000313|Proteomes:UP000218220};
KW Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|RuleBase:RU364014};
KW Repressor {ECO:0000256|RuleBase:RU364014};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU364014};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU364014};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT REPEAT 53..87
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 108..140
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 151..183
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 575..759
FT /note="Protein HIRA-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF07569"
FT REGION 382..437
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 382..397
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 398..424
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:PCG67124.1"
SQ SEQUENCE 822 AA; 90143 MW; 60F3CEE9A4871C7B CRC64;
KPIFSVDIHP TGKRFATGGQ GGDSGRVVVW NLNPVLFEAV EVDPNVPKML CQMDNHLACV
NCVRWSNGGK YLASGGDDRL VMVWGLSVAA NATPGKHKAE TWRCLATLRG HAGDVLDLAW
SPLDKWLASC SVDNSIIIWN AEKFPEMVCV LNGHSGLVKG VAWDPVGKYL ASQSDDKSLR
VWKTADWAQE IVITEPFEEC GGTTHVLRLS WSPDGQYVLS AHAMNGGGPT AQVVERDGWR
CDKDFVGHRK AVTCARFNNN IFVKEGKKCC CAAVGSRDRA LSIWLTSLKR PLVVVHDLFS
DSVLDLSWSS DGLNLLACSS DGTVACIQFT NKEIGTPLTM EEKNAFYEKI YGKCLANESG
GDLSANLLVE CPEILLAREK QEAKKEAAKE ETTPKSDKSQ PKSLLSPSAG SSGASSTPLR
PMDRQIETRT SDGKRRITPV FIPLTHADAN ESLSSQPGGT ENCFSTSSQS KSRIRVEVRD
DIVIHPNVSN HATSTQHNNS RTSDKYVVNK ACNTQYGTLS RLQLLPNNSA SSDPVWETYL
GSNVTCIACD VRWACVACAD GTLHVWQLAR HTATRALPPL ALMSQAAKLT LSGDTLAVVT
TSAELAMYDL STATCVIRPL CFRSLLSHGV TVTNCSLLDD GNPMISLSNG KSYIYSKGLC
AWVVWADACD PVWRCSGAAP NVRASRTSLY PLAKVNRTRP TSFTNSSYRS GAARSWLEAQ
VSSSLHLRRA QDYRHWLHAL FAHLVNHGTE DQLRSILDDM MGPSHCTSTP KKWQPTILGI
KKHELLEEML ALLVRQLRWQ RMYAEYSDQL SELKVHTVVN GH
//
