ID A0A2A4JFD6_HELVI Unreviewed; 1619 AA.
AC A0A2A4JFD6;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
GN ORFNames=B5V51_2598 {ECO:0000313|EMBL:PCG70777.1};
OS Heliothis virescens (Tobacco budworm moth).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Noctuoidea;
OC Noctuidae; Heliothinae; Heliothis.
OX NCBI_TaxID=7102 {ECO:0000313|EMBL:PCG70777.1, ECO:0000313|Proteomes:UP000218220};
RN [1] {ECO:0000313|EMBL:PCG70777.1, ECO:0000313|Proteomes:UP000218220}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HvINT- {ECO:0000313|EMBL:PCG70777.1};
RC TISSUE=Whole body {ECO:0000313|EMBL:PCG70777.1};
RA Fritz M.L., Deyonke A.M., Papanicolaou A., Micinski S., Westbrook J.,
RA Gould F.;
RT "Contemporary evolution of a Lepidopteran species, Heliothis virescens, in
RT response to modern agricultural practices.";
RL Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620; EC=3.1.3.48;
CC Evidence={ECO:0000256|ARBA:ARBA00001490};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PCG70777.1}.
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DR EMBL; NWSH01001588; PCG70777.1; -; Genomic_DNA.
DR STRING; 7102.A0A2A4JFD6; -.
DR Proteomes; UP000218220; Unassembled WGS sequence.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IEA:UniProt.
DR GO; GO:0016043; P:cellular component organization; IEA:UniProt.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR GO; GO:0048666; P:neuron development; IEA:UniProt.
DR CDD; cd00063; FN3; 2.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 2.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR19134; RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE; 1.
DR PANTHER; PTHR19134:SF449; RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE GAMMA; 1.
DR Pfam; PF00102; Y_phosphatase; 2.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00060; FN3; 2.
DR SMART; SM00194; PTPc; 1.
DR SMART; SM00404; PTPc_motif; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 2.
DR SUPFAM; SSF49265; Fibronectin type III; 1.
DR PROSITE; PS50853; FN3; 1.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 2.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Reference proteome {ECO:0000313|Proteomes:UP000218220};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..1619
FT /note="protein-tyrosine-phosphatase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5012856441"
FT DOMAIN 321..430
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 567..950
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 871..941
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT DOMAIN 1125..1309
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT REGION 76..115
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 664..685
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 985..1070
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1259..1306
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1339..1394
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 77..96
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 990..1033
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1034..1057
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1278..1292
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1339..1365
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1619 AA; 180699 MW; F95AD09CDB4B449E CRC64;
MYIHYTVGAI FIVFILCVHC DNVANDNEIK EIYVPSAPQN LTANNVTTDE VHLSWAPPLT
FTLRTLPNTN LDLKSQTLVP DHDKSTSNKK LEPQGDEPVN DVLSQDLPSD TITPERQKDF
EYTSYNWYKN DKHKYNDDYS SHVLIDDYRN KRDVRTHRHR KRWPENDTDT KLHFEKNLEV
LEAHPVEQKE VVKKSFTQAK HKETTQVAYV LYYEQGVPRY DVNIVNGTQN SADVKRKNVF
PSDLGMEDYS RATKNLTLLN TSGKVTKVVG FRLRNLKPFT PYKIWVRAFY NFSLDGVKSS
DLLDRLGPKS DPLYVLTDVR PPSAPIILNL TCDQTKRTLY LQWRQPLEYN NSLDQYVVTL
RKIPEQQPRT RLTLPTNKND IETTIPIEVD LWNVTRYEVK VYAVTQSVAR EKSFINGEES
NPEEVSSEWC AAHSEAMSPR DVPESDGVSN AALLAVCPLL VFAVAVAVLY WRCRARLSKC
ISAAYNYLEE GGERAVRAPL NSYKKPVVNC SPLVSCTSGA AAEGGAGDAC GEAARPPRMA
GAAQPAVPAL AFPAHVAALH ADGDIGFSKE YEIVVAKSAA LGHTSHHSHR PENRLKNRYL
NITAYDHSRV CVSAGTRCGA AGCVGGGGGG GGRSAACDYV NANFIDGMLP QLQPHHVARI
RRKLERRNRP HRQSSVKPTK PPPNLAEGIE SAFLNIEFSG IVESDEQNSD SDSDRSDSDS
DLDDVYVDIE GVSTRVKLEW LVWRRRYIAT QGPTPATLDA FWRMIWQHRV HTVVMITNLV
ERGRRKCDMY WPAGGAGSSA EFGGVRVTLL HEDVRAAYTV RHMRVQYCRT DAAGGSTPTS
GDSSTSGTEG RTVVQYHYTV WPDHGTPRHP LAVLPFVKAA GKHSSTVLVH CSAGVGRTGT
YIVLDAQLNQ LKLTGTLSPL GFLCRARTQR NHLVQTEEQY VFVHDALLEH VRSGDTEVEF
PKARQYLAKL LEPISDEELA VLDLNPPKHK SMNDLSNGVE NGETSSIKSS QNASEKEVLE
NGSQMSIKTD DLNSEQSKSV KDSEGTDEPK EGMVNGEENE GVYDLAPRST DTYSKKMQAY
NNMTDTEKEE MRRANRAENY ALLERMRSLA NRHHTYQGPP PVNLLEKQFL LITRSCVEAS
VCARAPHNAE KNRPGGILPS DSARVMLVPK PGVEGSEYVN ASWVCGRRRV REYAVAQHPA
TGADLWRLLW DHTAQLVLLL SDTSDPECEI FWPTEEEKEL FVANFRASFV SKETYVAHRK
VDRKTPAESP VEPETNGYRR QESSDCADDE RLIPENGSPV ADTEPAYRFD RTELRLERLS
AGNRDLSARK SIANGDLFSS LSEKKNGPKS PRSPSKMSLK NFKLSSPTKF KFPDWGNRTA
GSPPDTAPPP PPVAPALSVE EEAELRRPCY YFEKVEKVPE DVPLDRVIEV TNVSVHSLQD
DYQLSVKFIK CSRWLDGETT DYVQGRPDDN EFVRAVRHAA GDSEREQAID RLIEPYKDSF
ALVEYVAGCQ MEYKNGPVVV VDKYGGWKAM NFCTMSAACG GARAVSAHDP GAAYRAPHDA
RASLYCWAAL GAHARTAPDH ARAHHHAALL AAYCALASYG DLLTHTNQRF PETPEQESR
//
