ID A0A2A4JG03_HELVI Unreviewed; 338 AA.
AC A0A2A4JG03;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 11.
DE RecName: Full=TNF family profile domain-containing protein {ECO:0000259|PROSITE:PS50049};
GN ORFNames=B5V51_2747 {ECO:0000313|EMBL:PCG70638.1};
OS Heliothis virescens (Tobacco budworm moth).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Noctuoidea;
OC Noctuidae; Heliothinae; Heliothis.
OX NCBI_TaxID=7102 {ECO:0000313|EMBL:PCG70638.1, ECO:0000313|Proteomes:UP000218220};
RN [1] {ECO:0000313|EMBL:PCG70638.1, ECO:0000313|Proteomes:UP000218220}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HvINT- {ECO:0000313|EMBL:PCG70638.1};
RC TISSUE=Whole body {ECO:0000313|EMBL:PCG70638.1};
RA Fritz M.L., Deyonke A.M., Papanicolaou A., Micinski S., Westbrook J.,
RA Gould F.;
RT "Contemporary evolution of a Lepidopteran species, Heliothis virescens, in
RT response to modern agricultural practices.";
RL Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the tumor necrosis factor family.
CC {ECO:0000256|ARBA:ARBA00008670}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PCG70638.1}.
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DR EMBL; NWSH01001631; PCG70638.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2A4JG03; -.
DR STRING; 7102.A0A2A4JG03; -.
DR Proteomes; UP000218220; Unassembled WGS sequence.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR GO; GO:0005164; F:tumor necrosis factor receptor binding; IEA:InterPro.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR Gene3D; 2.60.120.40; -; 1.
DR InterPro; IPR021184; TNF_CS.
DR InterPro; IPR006052; TNF_dom.
DR InterPro; IPR008983; Tumour_necrosis_fac-like_dom.
DR PANTHER; PTHR15151:SF13; ECTODYSPLASIN-A; 1.
DR PANTHER; PTHR15151; PROTEIN EIGER; 1.
DR Pfam; PF00229; TNF; 1.
DR SUPFAM; SSF49842; TNF-like; 1.
DR PROSITE; PS00251; TNF_1; 1.
DR PROSITE; PS50049; TNF_2; 1.
PE 3: Inferred from homology;
KW Cytokine {ECO:0000256|ARBA:ARBA00022514};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000218220};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 69..93
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 216..336
FT /note="TNF family profile"
FT /evidence="ECO:0000259|PROSITE:PS50049"
SQ SEQUENCE 338 AA; 38071 MW; 19E29615311B793B CRC64;
MDGERKIHMS EGVPLNSPGA ANIFLNTGKN TKVNSPEGTV IHLNTEKPSD LGVHINTTFS
IASSKKIKLL FVLNFVLSVT CMVISCSIAF YYWNEMISMR RQLDMIKDHF IVHNLNQDRL
VQSALVARPR PSSLAEAREP RARSFEEDEV PQNARKYYVE DLGEDMLLVD SKKKNASKDN
APVYDLTLLQ KELVVAQFNG AIREFNLGTQ SIMGPWVRDE EVSSKNSEDK IELNSNYVTI
KEGGLYLVYA QVVYLSQSPN CFFVWARQTG KEPRLLSTCA TGDDSSKRSL SKSQMSCSVQ
TVARLYKGDT VNIAQREPNR TVWLRPGYSY FGFVKLSS
//
