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Database: UniProt
Entry: A0A2A4JHF3_HELVI
LinkDB: A0A2A4JHF3_HELVI
Original site: A0A2A4JHF3_HELVI 
ID   A0A2A4JHF3_HELVI        Unreviewed;      1016 AA.
AC   A0A2A4JHF3;
DT   20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT   20-DEC-2017, sequence version 1.
DT   05-JUN-2019, entry version 9.
DE   RecName: Full=Ubiquitinyl hydrolase 1 {ECO:0000256|SAAS:SAAS01044305};
DE            EC=3.4.19.12 {ECO:0000256|SAAS:SAAS01044305};
GN   ORFNames=B5V51_1806 {ECO:0000313|EMBL:PCG71477.1};
OS   Heliothis virescens (Tobacco budworm moth).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Lepidoptera; Glossata; Ditrysia;
OC   Noctuoidea; Noctuidae; Heliothinae; Heliothis.
OX   NCBI_TaxID=7102 {ECO:0000313|EMBL:PCG71477.1, ECO:0000313|Proteomes:UP000218220};
RN   [1] {ECO:0000313|EMBL:PCG71477.1, ECO:0000313|Proteomes:UP000218220}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HvINT- {ECO:0000313|EMBL:PCG71477.1};
RC   TISSUE=Whole body {ECO:0000313|EMBL:PCG71477.1};
RA   Fritz M.L., Deyonke A.M., Papanicolaou A., Micinski S., Westbrook J.,
RA   Gould F.;
RT   "Contemporary evolution of a Lepidopteran species, Heliothis
RT   virescens, in response to modern agricultural practices.";
RL   Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Thiol-dependent hydrolysis of ester, thioester, amide,
CC         peptide and isopeptide bonds formed by the C-terminal Gly of
CC         ubiquitin (a 76-residue protein attached to proteins as an
CC         intracellular targeting signal).; EC=3.4.19.12;
CC         Evidence={ECO:0000256|SAAS:SAAS01117307};
CC   -!- SIMILARITY: Belongs to the peptidase C19 family.
CC       {ECO:0000256|SAAS:SAAS01045498}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:PCG71477.1}.
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DR   EMBL; NWSH01001376; PCG71477.1; -; Genomic_DNA.
DR   Proteomes; UP000218220; Unassembled WGS sequence.
DR   GO; GO:0004843; F:thiol-dependent ubiquitin-specific protease activity; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0016579; P:protein deubiquitination; IEA:InterPro.
DR   GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR   Gene3D; 3.30.40.10; -; 1.
DR   InterPro; IPR035927; DUSP-like_sf.
DR   InterPro; IPR038765; Papain-like_cys_pep_sf.
DR   InterPro; IPR006615; Pept_C19_DUSP.
DR   InterPro; IPR001394; Peptidase_C19_UCH.
DR   InterPro; IPR018200; USP_CS.
DR   InterPro; IPR028889; USP_dom.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   InterPro; IPR001607; Znf_UBP.
DR   Pfam; PF06337; DUSP; 2.
DR   Pfam; PF00443; UCH; 1.
DR   Pfam; PF02148; zf-UBP; 1.
DR   SMART; SM00695; DUSP; 2.
DR   SUPFAM; SSF143791; SSF143791; 2.
DR   SUPFAM; SSF54001; SSF54001; 1.
DR   PROSITE; PS51283; DUSP; 2.
DR   PROSITE; PS00972; USP_1; 1.
DR   PROSITE; PS00973; USP_2; 1.
DR   PROSITE; PS50235; USP_3; 1.
DR   PROSITE; PS50271; ZF_UBP; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000218220};
KW   Hydrolase {ECO:0000256|SAAS:SAAS01044238};
KW   Metal-binding {ECO:0000256|SAAS:SAAS01044152};
KW   Protease {ECO:0000256|SAAS:SAAS01044292};
KW   Reference proteome {ECO:0000313|Proteomes:UP000218220};
KW   Thiol protease {ECO:0000256|SAAS:SAAS01044269};
KW   Ubl conjugation pathway {ECO:0000256|SAAS:SAAS01044331};
KW   Zinc {ECO:0000256|SAAS:SAAS01044373};
KW   Zinc-finger {ECO:0000256|SAAS:SAAS01044352}.
FT   DOMAIN       28     93       UBP-type. {ECO:0000259|PROSITE:PS50271}.
FT   DOMAIN      145    643       USP. {ECO:0000259|PROSITE:PS50235}.
FT   DOMAIN      641    740       DUSP. {ECO:0000259|PROSITE:PS51283}.
FT   DOMAIN      752    855       DUSP. {ECO:0000259|PROSITE:PS51283}.
FT   ZN_FING      28     93       UBP-type. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00502}.
FT   REGION      254    327       Disordered. {ECO:0000256|MobiDB-lite:
FT                                A0A2A4JHF3}.
FT   REGION      381    408       Disordered. {ECO:0000256|MobiDB-lite:
FT                                A0A2A4JHF3}.
FT   REGION      933   1016       Disordered. {ECO:0000256|MobiDB-lite:
FT                                A0A2A4JHF3}.
FT   COMPBIAS    254    280       Polyampholyte. {ECO:0000256|MobiDB-lite:
FT                                A0A2A4JHF3}.
FT   COMPBIAS    303    319       Polar. {ECO:0000256|MobiDB-lite:
FT                                A0A2A4JHF3}.
FT   COMPBIAS    935    951       Polar. {ECO:0000256|MobiDB-lite:
FT                                A0A2A4JHF3}.
FT   COMPBIAS    966    989       Polyampholyte. {ECO:0000256|MobiDB-lite:
FT                                A0A2A4JHF3}.
FT   COMPBIAS   1002   1016       Basic. {ECO:0000256|MobiDB-lite:
FT                                A0A2A4JHF3}.
SQ   SEQUENCE   1016 AA;  114285 MW;  188A91BCC9780A36 CRC64;
     MDKGVTCDHL NKLADVLGKE LWQTKETLTC FDCGCPGPNL WICLQPDCHH IGCSEDKNDH
     STLHQKNFPL HCVHMNVSTE RIWCYLCEKE VHIRAALAYA ASPDSTCAES PGRLGAVGLS
     MVDDELDPEA HDMDYDDDAR PRGLVGLQNM GNTCYMNAAL QALSNTAPLT SYFLECAAAV
     AVLAADKKPG ISRAYQKLVK EMWSRKTRGY VVPNGVLYGI RNVHPMFRGY HQHDTQEFLR
     CFMDQLHEEL KEPVWDSTSE DKLGSDADGD HSDTRALHVR RRAASSGASD APFFARMRRK
     SPAPSSYSES RTEGYLRVQT QEPIASRHRR SASFAGTHHL QYNMYSQQPN GTDSVRGAAQ
     GLCGSESSLS CSSEADERYE TCSSGASDAP DTRTEHHKGG VPLGGGDGSG GGVRFRSVIS
     DVFDGKLLSS VQCLICNRVS TRVETFQDLS LPIPSREHLA VIRCQQPILN HHVPHGQESW
     VWWLLSWLRS WFYGPVVSLQ DCLAAFFSAD ELKGDNMYSC SRCNKLRNGV KMSGVVRLPE
     VLCVHLKRFR HELMFSAKVG ARVSFPINDL NMAPYTHKDC TSKISRYELC AVICHAGTAG
     GGHYTCVARN GRSWYTFDDH CVQPLPYHHL PHCEAYVLFY RKVNPQMVTL RQKAAEILES
     TSVEPNDIKF YISKQWINKF NTWAEPGPID NSDFVCWHGG VRPDRAPHLH HLAALVPQPL
     WEFLYLHFGG GPAVSHVHEC GVCARAAQRL RTRRARELAA FCDLHASFQE QERPHAIYGI
     SMHWFRQWQA FVRNKTQQPP PPVDNSGIVS KQEIDGVTTL TIKPGSDHAQ LSEELWRFFT
     SIYGGGPEVR LKSPTTPAPP PIFHDENTFE RRLSRKYSES DKEEYCTKST SEMNIRDTIH
     GELQKNQSLQ NINRRYKVKA TAESDEDVNY RRTFQYKRTE TNGNYQDSDS DDMDASPGRA
     NTVRMENGLD SDHDANDNPV SRDKADTDLP NLDSISLKSK PSKSGKVRKI KRRTVK
//
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