ID A0A2A4JIV5_HELVI Unreviewed; 1473 AA.
AC A0A2A4JIV5;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
GN ORFNames=B5V51_1778 {ECO:0000313|EMBL:PCG71504.1};
OS Heliothis virescens (Tobacco budworm moth).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Noctuoidea;
OC Noctuidae; Heliothinae; Heliothis.
OX NCBI_TaxID=7102 {ECO:0000313|EMBL:PCG71504.1, ECO:0000313|Proteomes:UP000218220};
RN [1] {ECO:0000313|EMBL:PCG71504.1, ECO:0000313|Proteomes:UP000218220}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HvINT- {ECO:0000313|EMBL:PCG71504.1};
RC TISSUE=Whole body {ECO:0000313|EMBL:PCG71504.1};
RA Fritz M.L., Deyonke A.M., Papanicolaou A., Micinski S., Westbrook J.,
RA Gould F.;
RT "Contemporary evolution of a Lepidopteran species, Heliothis virescens, in
RT response to modern agricultural practices.";
RL Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PCG71504.1}.
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DR EMBL; NWSH01001370; PCG71504.1; -; Genomic_DNA.
DR STRING; 7102.A0A2A4JIV5; -.
DR Proteomes; UP000218220; Unassembled WGS sequence.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IEA:UniProt.
DR GO; GO:0016043; P:cellular component organization; IEA:UniProt.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR GO; GO:0048666; P:neuron development; IEA:UniProt.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 1.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR InterPro; IPR008356; Tyr_Pase_KIM-con.
DR PANTHER; PTHR46198; PROTEIN-TYROSINE-PHOSPHATASE; 1.
DR PANTHER; PTHR46198:SF4; PROTEIN-TYROSINE-PHOSPHATASE; 1.
DR Pfam; PF00102; Y_phosphatase; 3.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00194; PTPc; 1.
DR SMART; SM00404; PTPc_motif; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000218220}.
FT DOMAIN 1149..1466
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1400..1457
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT REGION 27..56
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 76..98
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 194..234
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 388..457
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 822..850
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 39..56
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 79..93
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 388..412
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 413..445
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 1407
FT /note="Phosphocysteine intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR608356-50"
FT BINDING 1324
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR608356-51"
FT BINDING 1407..1413
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR608356-51"
FT BINDING 1451
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR608356-51"
SQ SEQUENCE 1473 AA; 166579 MW; 170608091DCC5396 CRC64;
MHKRIDYKYT TIPRPLAQIA ADLGADLSQE SRAKKYSATR SPSLEKDDKS PFLLSAKSSD
KDKEVFGFDS AAVEKLNENM SERSPEGEEA SPSNLRRFRS VSTRLNMCSV NEGSHLEGQQ
ERLEMQNSPR VVECSSAKEK SSAPKFDFSP KLLAETMVSP RFFTPPETVS PMFFAEPSPK
SVYYDTVRSP KFFPETPRDA EVPQSPRALG DHLNRNGVAE KPCSPRVLNR PSPKVHSYNK
ENYFTFEQSC LEDDRLTARP RKYGGRNSIE KERFTPPADK EVRKYRRHHS CETNYKTIEL
NISKVEDNKD SETKLGEDVT DCCLKMDTLE IEPKVIEEPE VAPSPSNTAH ARRQRLKSIS
LDSDNAKIIE QNLGLPIAKQ MKDQMNEAYK NQETSTSCES MERYTQKTPT SDRPMFKFEE
ETKDKNPETE EPKSPDVKHK KSLRQSSDTQ SFLDMPRFSP KEFEITVTSV EGATIAAEAQ
TKKKGKNLRN LRIDLTKRDS DLEKELLEFE KLYTDAEEKK VKTPTLKVKA TSLDSSETVN
LSLPQKKTLE IPQNSVSMPN TPKRQLKRIL AQKNVKHDFA GAKLGYNSLQ SNAEQRRLYM
KGQDSGIYLR ENHAALMLYQ PGTSRMGSRT MGSFDENMAD FENTPEINIS GADNRTYHVD
TGQTLGSNLL NYKQNLSVSS TNLKTLPEGV PSDDFEPSAE DEKITKKLHR RNSNQSLMLS
THSLQSSNCS LNSAGASCHN LTTVRTSFSN FSLNSDCRQK KLSIDRRDSN TSLANAEHLT
PTTRVTCSSS GNVSGELSKN CLLQRRGSNN SLTLNILSSN NLSRHSSNSS LNKDAKPGQK
KGLLERRSSN TSLTLNINQS NPQLSVNRGL SVSNYNLNGS TCNLSRYNSN ISIDNPPTEP
RKGILERRSS NTSLTLNIQP REEPRDLEID ETLIDTNLKD LPHRDKHRKS LSTENLIPKS
YKNRTRLRST DKGVGFGSHD NLWSTSYATE QEYPQNLTYV CGDQENEIIY AFGRQDDPNF
QQGFTRNITT KPLSPQSTSE DFRLYLANMQ HLQNASSVLS RQNLRDLNDV FQNGYSKVKC
HSLGEGQHCC SGRVEDIAKD NPQMVIPDPV PSQPCSEYQK MLLRNLHQEF WDMPTNFQEK
PIVSGSHPKN RYKTILPNEH SRFILRADPG STEGYINANY IKGHEYTKNT YIATQGPLQN
TIHDFWLMVY QNTLEHSARL SDQPSDPPSD GSDAPPIQKV VMLTNFIENN RQKCEKYFPL
ELNEEFIIPN PDYPDDETDV FVVKNSGMIR KPGYTIRNLT VVYNKCDSDS EVTVYHYWFH
NWADHKCPKD VNALLNLSLD VLKDNVYDFS GATDYNDDMC KCDTPKQDSK FVFPPLDQPA
PCEITVNVST PFDFSRETVS PPTIVHCSAG IGRTGCLLAI LNGIKQLTIE HKVDVLGIVC
NMRLNRGGMV QNSEQYELIH KVLCLYEQAC LPL
//
