ID A0A2A4JK18_HELVI Unreviewed; 996 AA.
AC A0A2A4JK18;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=Kazal-like domain-containing protein {ECO:0000259|PROSITE:PS51465};
GN ORFNames=B5V51_1200 {ECO:0000313|EMBL:PCG72068.1};
OS Heliothis virescens (Tobacco budworm moth).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Noctuoidea;
OC Noctuidae; Heliothinae; Heliothis.
OX NCBI_TaxID=7102 {ECO:0000313|EMBL:PCG72068.1, ECO:0000313|Proteomes:UP000218220};
RN [1] {ECO:0000313|EMBL:PCG72068.1, ECO:0000313|Proteomes:UP000218220}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HvINT- {ECO:0000313|EMBL:PCG72068.1};
RC TISSUE=Whole body {ECO:0000313|EMBL:PCG72068.1};
RA Fritz M.L., Deyonke A.M., Papanicolaou A., Micinski S., Westbrook J.,
RA Gould F.;
RT "Contemporary evolution of a Lepidopteran species, Heliothis virescens, in
RT response to modern agricultural practices.";
RL Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PCG72068.1}.
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DR EMBL; NWSH01001221; PCG72068.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2A4JK18; -.
DR STRING; 7102.A0A2A4JK18; -.
DR Proteomes; UP000218220; Unassembled WGS sequence.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:InterPro.
DR CDD; cd00104; KAZAL_FS; 2.
DR Gene3D; 3.30.60.30; -; 3.
DR Gene3D; 3.15.10.30; Haemolymph juvenile hormone binding protein; 1.
DR InterPro; IPR010562; Haemolymph_juvenile_hormone-bd.
DR InterPro; IPR002350; Kazal_dom.
DR InterPro; IPR036058; Kazal_dom_sf.
DR InterPro; IPR039932; Spink4-like.
DR InterPro; IPR038606; To_sf.
DR PANTHER; PTHR21179:SF0; SERINE PROTEASE INHIBITOR KAZAL-TYPE 4; 1.
DR PANTHER; PTHR21179; SERINE-TYPE ENDOPEPTIDASE INHIBITOR; 1.
DR Pfam; PF06585; JHBP; 1.
DR Pfam; PF00050; Kazal_1; 2.
DR Pfam; PF07648; Kazal_2; 2.
DR SMART; SM00700; JHBP; 1.
DR SMART; SM00280; KAZAL; 4.
DR SUPFAM; SSF100895; Kazal-type serine protease inhibitors; 4.
DR PROSITE; PS51465; KAZAL_2; 4.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Reference proteome {ECO:0000313|Proteomes:UP000218220};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..996
FT /note="Kazal-like domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5013195562"
FT DOMAIN 368..421
FT /note="Kazal-like"
FT /evidence="ECO:0000259|PROSITE:PS51465"
FT DOMAIN 453..506
FT /note="Kazal-like"
FT /evidence="ECO:0000259|PROSITE:PS51465"
FT DOMAIN 535..588
FT /note="Kazal-like"
FT /evidence="ECO:0000259|PROSITE:PS51465"
FT DOMAIN 612..665
FT /note="Kazal-like"
FT /evidence="ECO:0000259|PROSITE:PS51465"
FT REGION 28..367
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 422..448
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 53..79
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 140..161
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 167..197
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 242..318
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 319..367
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 427..442
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 996 AA; 108359 MW; 337F535C63014BD0 CRC64;
MNNFVYIALL ICLGIVVVQG YGPKIYRKHH GNSHKSSHGS KQRPSHGSSQ HRSSQKGDSH
HGSSRRGDSH HESSQRRGSH HGPPQKRPFH NGFNDRGSND HGPFPKLALR KRPFSPSKDT
PFREVGHWDN SPVWTDDQGS FEISRERSGS FDNDDSDYDS RGSNDGYGPG DDSSYSRGDS
SGPDDSGSDS GDSGYGPESG SSEEFGPSRE DGSFYSHFHS KVPCKRPNTQ PPRRTTTMKP
TRRPRPPRPT PQPETTTTEA PTPRPTRRPT PGPTPRPTRW PTPGPTPGPT PRPTRWPTPE
PTPRPTPGPR PNPTSRPSRS TPRPSRGTES TGTVWHPNTH TEGTTHWETT TSLPETTTEG
EEEITTISPE ITNCIASCAS TPEYNPVCGS DGVTYDNEGK LFCANSCGVS VTLRRRSVCP
PPSFDYEDDN DQPPPTPPPT TTLNPSVGRT TSLSGFQRCM RLCRITASFT PVCGTDLVTY
MNMDRLKCAQ SCGEVVQVLC EKPCAACGYN PVTPKTTTLP PTTTSSSNVG RTTLVPNTKE
CVDACPATQE YNPVCGSNSV TYKNPGHLIC AQLCGIAVTI RRFGGCSPTT ASTTTTTTTT
TTTTTEASVT YSPAVVNCIR RCPVTSEYNP VCGTDDLTYS NLGNLECAKY CGADVELKYS
TRCIDEFDLG PDGTTTTSST TPNINGQKDV LTTTVKSTSL FTSPTTVRTT TTKTTPITTT
LSTSTLSSRT TATPISSTTL GFSIPQDVLD TIFKPTTTGL PLTTRTTTID PDADEDLDLD
ARRPCRDMSP ECLKQSLQTA LPAFANGIPE LGIESLDPYI LKEISLNLPG GIEIHFINGH
AKGLKKCIVD FARYDEDTFE TQLHCNLTIK GKYKSSGRLL VFPIDGDGES TIKCNNIKLH
SILKLGTTVK SDGQSYLYVK SSSIDHSYDG RVSYTMTNLF KGSPEISNAV LDFMNSNWKM
VAEEFGTPMV DFGVNSVMKN IRRLFEVVPI SELKKL
//
