ID A0A2A4JND3_HELVI Unreviewed; 1448 AA.
AC A0A2A4JND3;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Receptor protein-tyrosine kinase {ECO:0000256|ARBA:ARBA00011902, ECO:0000256|PIRNR:PIRNR000619};
DE EC=2.7.10.1 {ECO:0000256|ARBA:ARBA00011902, ECO:0000256|PIRNR:PIRNR000619};
GN ORFNames=B5V51_333 {ECO:0000313|EMBL:PCG72920.1};
OS Heliothis virescens (Tobacco budworm moth).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Noctuoidea;
OC Noctuidae; Heliothinae; Heliothis.
OX NCBI_TaxID=7102 {ECO:0000313|EMBL:PCG72920.1, ECO:0000313|Proteomes:UP000218220};
RN [1] {ECO:0000313|EMBL:PCG72920.1, ECO:0000313|Proteomes:UP000218220}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HvINT- {ECO:0000313|EMBL:PCG72920.1};
RC TISSUE=Whole body {ECO:0000313|EMBL:PCG72920.1};
RA Fritz M.L., Deyonke A.M., Papanicolaou A., Micinski S., Westbrook J.,
RA Gould F.;
RT "Contemporary evolution of a Lepidopteran species, Heliothis virescens, in
RT response to modern agricultural practices.";
RL Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
CC [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001171};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein
CC kinase family. EGF receptor subfamily. {ECO:0000256|PIRNR:PIRNR000619}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PCG72920.1}.
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DR EMBL; NWSH01001050; PCG72920.1; -; Genomic_DNA.
DR STRING; 7102.A0A2A4JND3; -.
DR Proteomes; UP000218220; Unassembled WGS sequence.
DR GO; GO:0098590; C:plasma membrane region; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0038127; P:ERBB signaling pathway; IEA:UniProt.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0042127; P:regulation of cell population proliferation; IEA:UniProt.
DR GO; GO:0000003; P:reproduction; IEA:UniProt.
DR CDD; cd00064; FU; 5.
DR CDD; cd05057; PTKc_EGFR_like; 1.
DR Gene3D; 3.80.20.20; Receptor L-domain; 2.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR006211; Furin-like_Cys-rich_dom.
DR InterPro; IPR006212; Furin_repeat.
DR InterPro; IPR032778; GF_recep_IV.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR000494; Rcpt_L-dom.
DR InterPro; IPR036941; Rcpt_L-dom_sf.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR008266; Tyr_kinase_AS.
DR InterPro; IPR020635; Tyr_kinase_cat_dom.
DR InterPro; IPR016245; Tyr_kinase_EGF/ERB/XmrK_rcpt.
DR PANTHER; PTHR24416:SF566; EPIDERMAL GROWTH FACTOR RECEPTOR; 1.
DR PANTHER; PTHR24416; TYROSINE-PROTEIN KINASE RECEPTOR; 1.
DR Pfam; PF00757; Furin-like; 1.
DR Pfam; PF14843; GF_recep_IV; 2.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR Pfam; PF01030; Recep_L_domain; 2.
DR PIRSF; PIRSF000619; TyrPK_EGF-R; 2.
DR PRINTS; PR00109; TYRKINASE.
DR SMART; SM00261; FU; 7.
DR SMART; SM00219; TyrKc; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 3.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PIRNR:PIRNR000619};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000256|PIRNR:PIRNR000619};
KW Membrane {ECO:0000256|PIRNR:PIRNR000619, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|PIRNR:PIRNR000619};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Receptor {ECO:0000256|PIRNR:PIRNR000619};
KW Reference proteome {ECO:0000313|Proteomes:UP000218220};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PIRNR:PIRNR000619};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Tyrosine-protein kinase {ECO:0000256|PIRNR:PIRNR000619}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..1448
FT /note="Receptor protein-tyrosine kinase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5013285982"
FT TRANSMEM 820..840
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 888..1145
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 1222..1242
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1397..1448
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1397..1419
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1420..1440
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 1013
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000619-1"
FT BINDING 894..902
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR000619-2"
FT BINDING 921
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR000619-2,
FT ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 1448 AA; 161550 MW; 8E84C2EF58D375E5 CRC64;
MVAARALLWC LWLVAVGTPV ASRGHRGHGD RHVPARHKHS EFVKGKICIG TNGRMSVPSN
RDTHYRNLRD RFTNCTYVDG NLELTWLQNE TMDLSFLKYI REVTGYVLIS HVNVRHIVLP
QLQIIRGRTL FKLNVREEEF ALMVTMSSAF TLELPALRDV LRGSVGIYNN YNLCHVKTIN
WDEIITGVNA TYVYVYDFAA AERDCPRCDS SCEAGCWGEG PENCQKFSKT ICSPQCAQGR
CFGRNPRDCC NAFCAGGCTG PLPSQCLACR NFYDEGTCSQ ECPPMQIYNP TTYSWEPNPN
GKYAYGATCV RNCPEHLLKD NGACVRSCPP NKTAVNGECI PCNVTCPKTC HAEKPIHSGN
IDSFKDCTII DGSIEILEMT FTGFQHVNPD YSFGERYAKM EPHKLEVFST VREVTGYLNV
QAHHPNFTSL SYFRNLEVIG GRQVVENLFA SLYIVKTSLK SLGLKSLKRV NSGAIAIMEN
KYLCFAEKIA WTKLVKSKDH KQIIQNNGDL HTCERADLVC DPQCSADGCW GPGPDQCLSC
KNFKFGETCL QNCSILPGLY KDGPKSCKEC HPECKDGCAG PTGANCTSCR HVRDGPYCVN
KCPDSRYTSD NATCLPCHRN CFPNGCTGPN NTVGEGACNF CKKAIISVEA TVESCLSEYE
PCPDGYYNEW VGNVKPLEGK VKVVCRKCHP RCKKCVGFGI HTQVCLQCNG YKRGDQCEDE
CPADDFTDEE RKTCTPCHPE CKGCMGSSST DCVKCKNLKI FLTTDETQNQ SLFNCTDTCP
SHMPHKIYFD EQLQNPIDEP YCSTHTNGNP NMVTAKIPTV LIIILVLALL LLVILGIIGY
TCRQKAKANK EAVKMTMVLT GCEDNEPLRP TNVKPNLAKL RIVKEVELRR GGMLGYGAFG
KVYKGVWVPE GENVKIPVAI KVLKDGTGAN TSKEFLEEAY IMASVEHPNL LQLLAVCMTN
QMMLITQLMP LGCLLDYVRT HKEKIGSKAF LNWCTQIARG MAYLEEKRLV HRDLAARNVL
VQTPNCVKIT DFGLAKLLEV NTDEYKAAGG KMPIKWLALE CIQHRIFTHK SDVWAFGVTI
WELLSYGARP YETISARTVP ELIENGLKLP QPSICTLDIY CIMVSCWMLD ADSRPTFKQL
ADTFAEMARD PGRYLVIPGD KFMRLPSYST QDEKEMIRNL SSAMEGPESL VEADEYLQPK
FKSGPSTNTT ISVIEVHQNS MKPSASWPAG GPTNECGTPD GASKSETWDH ELLRYNQANP
SVDGTELRHY YNNGVCASDS SSSRYCSDPM KGRPEGCENN FESKTKDAQV GNLKLNLPLD
EDDYLMPSPQ HTQNASTYMD LIGEGGENQE GIKDLRFSSF VGKRCVDNPE YLMSEESVLP
QTLGIPTEPV PMESLCMSES SFSESTPRPS TSKYLPQRSV EEESMSDHEY YNDLQRELQP
LRRNETTV
//
