ID A0A2A4JRE0_HELVI Unreviewed; 5312 AA.
AC A0A2A4JRE0;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 08-NOV-2023, entry version 24.
DE RecName: Full=AAA+ ATPase domain-containing protein {ECO:0000259|SMART:SM00382};
GN ORFNames=B5V51_13720 {ECO:0000313|EMBL:PCG74174.1};
OS Heliothis virescens (Tobacco budworm moth).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Noctuoidea;
OC Noctuidae; Heliothinae; Heliothis.
OX NCBI_TaxID=7102 {ECO:0000313|EMBL:PCG74174.1, ECO:0000313|Proteomes:UP000218220};
RN [1] {ECO:0000313|EMBL:PCG74174.1, ECO:0000313|Proteomes:UP000218220}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HvINT- {ECO:0000313|EMBL:PCG74174.1};
RC TISSUE=Whole body {ECO:0000313|EMBL:PCG74174.1};
RA Fritz M.L., Deyonke A.M., Papanicolaou A., Micinski S., Westbrook J.,
RA Gould F.;
RT "Contemporary evolution of a Lepidopteran species, Heliothis virescens, in
RT response to modern agricultural practices.";
RL Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PCG74174.1}.
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DR EMBL; NWSH01000793; PCG74174.1; -; Genomic_DNA.
DR STRING; 7102.A0A2A4JRE0; -.
DR Proteomes; UP000218220; Unassembled WGS sequence.
DR GO; GO:0005930; C:axoneme; IEA:UniProt.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0031514; C:motile cilium; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 2.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 2.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 2.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR013594; Dynein_heavy_tail.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR46532:SF4; DYNEIN HEAVY CHAIN 8, AXONEMAL-LIKE PROTEIN; 1.
DR PANTHER; PTHR46532; MALE FERTILITY FACTOR KL5; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 2.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08385; DHC_N1; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 2.
DR SMART; SM00382; AAA; 3.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000218220}.
FT DOMAIN 2275..2419
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2556..2813
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2883..3031
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT REGION 1..38
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 324..351
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3508..3549
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3695..3736
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3915..3956
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 12..26
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 5312 AA; 610276 MW; 0F1F71765D2DA384 CRC64;
MEGTEGGEVP AEVPPGAPPP EPPPEGAEDS QVDKDAPVQE LRKSVEIAED QPIDHDAIVA
EVAKQLAKKS SSIRKMSLTD GERVEVDKAA LEAILDVSSR IAGIQKRSRL SMSTLALGHE
SYKDKQAKAK EARNNRMGGL KQQHRYLLEN AAAILNKPQD YVLEGVYDAD VHIELLDSAI
AEGGRHCVVL CDALLPPVKM ESGRFVPNQK GKMERTYLSD ASTIGTEGKC VAMYRFKTKA
IDARNIGDDY YFVIFDINPE SANVVSGIYT TMQRVYIPAL KACQGWGDIN PPNPNSADII
RTYISKIMLF NDYLAKTKVD LDCCTRFKIN LALYEDELKD EEKMKAAITK TVILEEICSY
VKQWIRQITM VLVQSQQLRR EPSNIGPLAE LDHWRRQLTT FTSIIEHIKS EPTMMYIHTL
IRAKSKLLKK WRQLDNLVTD YYNEAFDNVK YLYALEKYCE PLYRCDPSTT QQYIPGLLYT
IRMIFATSRY YNTTKQISTL LVKVTNQILN MCMDFLTNNG KKNIWNQDKI KFMYKAKLCL
SLYYFYRECY AETQKEMMEA ADERPFDCSE MYIFGKFETF RKRLQKIIDL FQTYITYYVL
NKTTLEGIEE FATNFNKLFK TISTKTYDAL DHRRPDFDKD YKIYKDHVAN QELLLENFMI
NSVNKCPTTE IALHLLTRFE KLKLDCLYLE DQYYDLISTY TAEIEALRDR YNEEREQPEL
PRNMPPVAGR VMWIRFYDKN INMPMDVFKK HHEVITHMNT QRCIKLYNVL TIVFTEFELI
YHYAWAENVG QVRLGLIAPL LIRNPATNMY IINFSIYIPE CIREVEYMWQ LGLRVPDGAQ
IIAFCKDKIL GNYERIKYLV DRNNQIRRSM PKLYQPLLRA QLIKLENAFQ PGFSTITWTS
LEIPSYCEYI EKVLTEVDLF VKEVVDMKEA RIDAIMASIT KTLLVYLPEE AVDPASFYEE
NLLRRDEIAL ELQQKSWNAE IAVIELIHKF LDSVPSKQIQ ALKNNWLDIE KALKQVTSAT
RITTEDTVFM EIESPDRFDV VPIVNECNEL FAYFATKCVE ALIKCTRQSL DILRRRASVS
SFLTMTTDPA EQKKLRPLML TNMYLQIPKI SIKPTLDEIQ TSFSQVVLNC IMDIHRYVFM
WGQQEQIKKE QLGGVSLTTQ IRNTTGSRSG SNISGIRSYF RMVSEHKDIV RSVMALQGMM
YMYKPDIEKL LTGYGRFSHL WAEDRVNQVQ EFVDSNPLNV MVKDMLNKYE SQTEEVLSLP
ERHVIGSIQI NMGHIKLALH LESIEWKRIL GKLLCHAYKD RVIKLMQFIN DRMKTMGKKI
KDLDDVRVAM LCLELIREEF IGMDMELDLI EESYGTFHQF NIDVPKEDAD MVYGLRYAFQ
NMLLTVSTNF ITLRSRSGSN ISGIRSYFRM VSEHKDIVRS VMALQGMMYM YKPDIEKLLT
GYGRFSHLWA EDRVNQVQEF VDSNPLNVMV KDMLNKYESQ TEEVLSLPER HVIGSIQINM
GHIKLALHLE SIEWKRILGK LLCHAYKDRV IKLMQFINDR MKTMGKKIKD LDDVRVAMLC
LELIREEFIG MDMELDLIEE SYGTFHQFNI DVPKEDADMV YGLRYAFQNM LLTSQQIQQK
IVDMQGPLQS ELTEGVATFL EDVLKFDADF DAFGPLTPGL TAREASDRVI MFQSRFDELW
RRFEMYSSGE KLFGMEVKDY PILHQKKKEF NLLGKLYSLY LAVMNSIDGY FETPWVEIQI
EQIVAQLAEF DVRCRKLPKA MKDWPAFIEL KNKIDDFNQT CPLLELMADK SMKDRHWRRL
EKLMNCVLDV ESEAFTLANV MEAPLLKNKE DVEDICISAV KEKDIEAKLK QVTMDWALID
LQFANFKNRG ELLIKPQDTL DIITLLEDSL MILNSLASNR YNAPFKKEIL LWINKLVNTS
EILEKWLQVQ NLWMYLEAVF VGGDIAKQLP AEAKRFAGID KTYVKIMYRA RDIVNCVETC
TADDTLKQLL PHLYDQLEAC QKSLTGYLET KRLIFPRFFF VSDPVLLEIL GQASDPHSIQ
SHLPSIFDAI YTVDFDDKER IVVMNSSNGE SIPLEIPVPC LGGVEIWLNT LLDTMKNTVK
NIIANIAQTM IGDPEFEFLV GFWNFPGQAG LLGMQILWTS DAEYALKKAK ADRFIMRITN
QKFLDLLNGL IDQTIRDLAP LDRTQIETMI TIHVHQRDIF DDLVKMRIKT PGDFEWQKQA
RFYYIEDTDD CLVSITDVDF IYQNEYLGIT ERLVITPLTD RCYITLSQAI GMSMGGAPAG
PAGTGKTETT KDMGRTLGKL VIVFNCSDQM DFRGLGRIYK GLAQSGTWGC FDEFNRIELP
VLSVAAQQIY ICLTARREKR EFFIFSDGDT VSLNPEFAFI ITMNPGYAGR QELPENLKIQ
FRSVAMMVPD RQIIIRVKLA SCGFKDNIVL ARKFFTLYKL CEEQLSKQVH YDFGLRNILS
VLRTMGAQKR ANPDNTEENI MMRVLKEMNV SKLVDEDEPL FISLIEDLFP GMKLTQTVQR
EMQRAIVLVA ERTGLVNHPD WNLKIIQLFE TSLVRHGLMT MGPTGSGKTT CIHTLMAALT
EIGKPHREMR MNPKAITAPQ MFGRLDVATN DWTDGIFSTL WRRALKVKKS DTTWIVLDGP
VDAVWIENLN SVLDDNKTLT LANGDRITMA QNSKLVFEPD NVDNASPATV SRMGMVFLSS
SVLKWQPILE GWLKKRPQKE ADCFRHAFQK VYDEVHDYVQ QKLVAKMKLL EAIYIRQCID
VLIGLLQIEV PGGKAHSDRH LERLFIFAMM WSLGAVLELD MRTRMSEFMT KLPVKMDWPG
AKHKEWVMPF EYNVNPAGAW EHWSESVEDY IYPSDTIPEY ASILVPNIDN VCITFLITTI
AAQDKAVLLI GEQGTAKTVM LKSYMTKYDS EVKLFKIINF SSATTPNMFQ RIIESYVEKR
VGMTYGPPGG RAMTVFVDDI NMPVVNEWGD QVTNEIVRQM MECGGFFSLD KPGDFITIAG
IQMFGAMIHP GGGRNDIPPR LKRQFNIFNC TLPSTISMDK IFDTISTGYF CKQRFDKKIV
EFMPKLVSVT RVMWQQTKIK MLPTPAKFHY VFNLRDLSRI WEGILYIKRE ELTSINTALK
LWFHECLRVI SDRFTTFEDK EWFVTNFWKT AAQELPEYKA EFPEEETFFV NFLREPIDPT
GDEDEDFSTD APKVYEELPS WEFLLKKLVT FQETFNEQIR GAHLDLVFFH DAMVHLFIIS
RIINTPRGNA LLVGVGGSGK QSLTKLASFI ANFSFYQITL TRSYNVNNFM DDIKVLYRVA
GLQGRGISFI FTDNDIKDEQ FLEFLNNILS SGEIANLFPK EEMDEIMNEL TPIMKKYAPK
RIPVPDVLYE YFIIRSRANL HVVLCFSPVG EKFRSRALKF PGLISGSTMD WFQKWPKEAL
IEVAHHFLWE FQVVCSQDTK QQLIEIMGIV QDNVADTCVA YYDRFRRQTH VTPKSYLSFL
EGYKVLYKEK HDNIAEMARR MTTGLGKLVE AAASVDVLKK ELEIKELEIK EATSKAEEVL
EAVADSQAAA EVVKAEVLEV KDRAVKLVNV IAAETAVAED KLAAAKPALD AAEAALLTIN
AADIATVRKL GKPPHLITLI MDAVIILFRK RIDPIRPDPE KQCLTASWAE SLKVMADARF
LSNLKNYPKD EINAEMVDLL QPYFTFPMTT GLGKLVEAAA SVDVLKKELE IKELEIKEAT
SKAEEVLEAV ADSQAAAEVV KAEVLEVKDR AVKLVNVIAA ETAVAEDKLA AAKPALDAAE
AALLTINAAD IATVRKLGKP PHLITLIMDA VIILFRKRID PIRPDPEKQC LTASWAESLK
VMADARFLSN LKNYPKDEIN AEMVDLLQPY FTFPQYTFEA AKIACGNVAG LISWTIAMAQ
FYSVNKDVLP LKANLAVMQG KYQAAKRELE AAEAQLEAKE RELAHVQKQF DEAMTLKQAV
LDDAAKCQQK MDAATALING LSGERVRWTE QSALFKSEIE RLVGDILLLT GFLSYSGPFN
QEFRALLISN WSGELLRRKI PVSMNLNITD QLTDTATIGE WNLCGLPTDE LSIQNGIIVT
KAARYPLLID PQTQGKIWIK NTEKFNDLIV TTLNHKYFRN HIEDCVSLGR PMLIEDVAEE
LDPVLDNVLE KNYIKIGSTY KVRLGDKEID VTAGHRIYIT TKLPNPAYTP EISARTSIID
FTVTMQGLED QLLGRVILTE KAEMEAERTQ LIMDVTANRR KIQELEANLL HKLTTIQGSL
VEDVSLIQVL NITKTTATEV KEKLDVAKET EMKINLAREE YRPVATRGSV LYFLVCNMSL
VCNMYQTSLA QFLERFDISL ERSPQSPITF RRIGFIIDYL TFDVFKFISR GFYEKHKYLF
TVLLTLKIDL QKEYITFEEF QTFIKGLEDQ LLGRVILTEK AEMEAERTQL IMDVTANRRK
IQELEANLLH KLTTIQGSLV EDVSLIQVLN ITKTTATEVK EKLDVAKETE MKINLAREEY
RPVATRGSVL YFLVCNMSLV CNMYQTSLAQ FLERFDISLE RSPQSPITFR RIGFIIDYLT
FDVFKFISRG FYEKHKYLFT VLLTLKIDLQ KEYITFEEFQ TFIKGGAALD LNACPPKPYK
WVTDMSWLNL VQLSSLRQFT NILNQVCNNE KGWKSWFDKE APEDEPLPDG YQNLDVFRKL
LVVRAWCPDR TLAQSLKYVV NSMGARYSEA VIVNYEQMVL ESRPLVPLIG FLAMGSDPTP
SIEVTAKRME NLCSSISMGQ GQEIHARKLI DRGLKEGLWV LLQNCHLGLE YMVEVMEQFG
ELEKDPEQIH ECFRLWITTE VHEKFPITLL QMSIKYTCEP PSGIKAGLMR TYDSMSQDFL
DYSDSPFYLP LIYTISFLHT VVQERRKFGP LGWNIPYEFN SADWLSSCMF VQNHLDALEP
GQSVSWTTVR YMVSAVQYGG RVTDDYDTRL LVTFCRVWFS DQIFTDEFQF YKGYGILKFK
NIPEYLEEIE RMKTVDPPQA YGLHTNADIT YQRNTTQELL DTILSIQPKE SSSGGGETRE
ASVYRQSKEM LEKVPPDFDP HEVLARLRLY GILHSMVIFL RQEIDRMQKV ILLVRTTLKD
LLLAIDGTII MNEALRDSLD NIYDAKVPNI WLRSSWSSST LGFWFTEFLE RTIQFSTWCF
QARPNSFWMT GFFNPQGFLT AMRQEVTRAH KGWALDMVTL HNDVTKFTLE EIKTPPPEGV
YIHGVFLDGA GWDRRNLRLC ESTIKVVFTV LPVVHVYAIN STAPKDPKLY QCPVYKKPVR
TGLTFITPLW LPTIKNPDHW ILRGVAMLCD IK
//