ID A0A2A4JT56_HELVI Unreviewed; 2774 AA.
AC A0A2A4JT56;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Serine/threonine-protein kinase TOR {ECO:0000256|RuleBase:RU364109};
DE EC=2.7.11.1 {ECO:0000256|RuleBase:RU364109};
GN ORFNames=B5V51_12054 {ECO:0000313|EMBL:PCG75225.1};
OS Heliothis virescens (Tobacco budworm moth).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Noctuoidea;
OC Noctuidae; Heliothinae; Heliothis.
OX NCBI_TaxID=7102 {ECO:0000313|EMBL:PCG75225.1, ECO:0000313|Proteomes:UP000218220};
RN [1] {ECO:0000313|EMBL:PCG75225.1, ECO:0000313|Proteomes:UP000218220}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HvINT- {ECO:0000313|EMBL:PCG75225.1};
RC TISSUE=Whole body {ECO:0000313|EMBL:PCG75225.1};
RA Fritz M.L., Deyonke A.M., Papanicolaou A., Micinski S., Westbrook J.,
RA Gould F.;
RT "Contemporary evolution of a Lepidopteran species, Heliothis virescens, in
RT response to modern agricultural practices.";
RL Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001433};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775,
CC ECO:0000256|RuleBase:RU364109};
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family.
CC {ECO:0000256|ARBA:ARBA00011031, ECO:0000256|RuleBase:RU364109}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PCG75225.1}.
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DR EMBL; NWSH01000622; PCG75225.1; -; Genomic_DNA.
DR STRING; 7102.A0A2A4JT56; -.
DR Proteomes; UP000218220; Unassembled WGS sequence.
DR GO; GO:0031931; C:TORC1 complex; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0106310; F:protein serine kinase activity; IEA:RHEA.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0044877; F:protein-containing complex binding; IEA:InterPro.
DR GO; GO:0010507; P:negative regulation of autophagy; IEA:UniProt.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0051247; P:positive regulation of protein metabolic process; IEA:UniProt.
DR GO; GO:0051128; P:regulation of cellular component organization; IEA:UniProt.
DR GO; GO:0042221; P:response to chemical; IEA:UniProt.
DR CDD; cd05169; PIKKc_TOR; 2.
DR Gene3D; 1.20.120.150; FKBP12-rapamycin binding domain; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 3.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 2.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR003152; FATC_dom.
DR InterPro; IPR009076; FRB_dom.
DR InterPro; IPR036738; FRB_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR024585; mTOR_dom.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR003151; PIK-rel_kinase_FAT.
DR InterPro; IPR014009; PIK_FAT.
DR InterPro; IPR026683; TOR_cat.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR11139; ATAXIA TELANGIECTASIA MUTATED ATM -RELATED; 1.
DR PANTHER; PTHR11139:SF9; SERINE_THREONINE-PROTEIN KINASE MTOR; 1.
DR Pfam; PF11865; DUF3385; 1.
DR Pfam; PF02259; FAT; 1.
DR Pfam; PF02260; FATC; 1.
DR Pfam; PF08771; FRB_dom; 2.
DR Pfam; PF00454; PI3_PI4_kinase; 2.
DR SMART; SM01346; DUF3385; 1.
DR SMART; SM01343; FATC; 1.
DR SMART; SM00146; PI3Kc; 2.
DR SMART; SM01345; Rapamycin_bind; 2.
DR SUPFAM; SSF48371; ARM repeat; 2.
DR SUPFAM; SSF47212; FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP); 2.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 2.
DR PROSITE; PS51189; FAT; 1.
DR PROSITE; PS51190; FATC; 1.
DR PROSITE; PS00915; PI3_4_KINASE_1; 2.
DR PROSITE; PS00916; PI3_4_KINASE_2; 2.
DR PROSITE; PS50290; PI3_4_KINASE_3; 2.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU364109};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000256|RuleBase:RU364109};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU364109};
KW Reference proteome {ECO:0000313|Proteomes:UP000218220};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Serine/threonine-protein kinase {ECO:0000256|RuleBase:RU364109};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU364109}.
FT DOMAIN 1325..1870
FT /note="FAT"
FT /evidence="ECO:0000259|PROSITE:PS51189"
FT DOMAIN 2040..2359
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT DOMAIN 2396..2709
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT DOMAIN 2742..2774
FT /note="FATC"
FT /evidence="ECO:0000259|PROSITE:PS51190"
SQ SEQUENCE 2774 AA; 319635 MW; 376C3E9E885A0C02 CRC64;
MKMTSFQVSD LVSGLKSRHA ETRHKAIREL LHFTKTDLRE MSQESLRQVL DDFNQQIHAL
TSSYDNNEKK AGILTIVCLI GGDTETTKTR NIRYAYYLRN VFPSTDYNVL ELGAKTMGRL
AVTLGIKRGE YVESELKRAY EWLAEERNEG KRLSAVMILR ELAICMPSYF FQHINGFFNY
IMIPLRDPKE QIREAAAKAL RAALVITSQR EIPEQSNKAH WYIQCYEQSM LSFAEQPGRE
RGLSRDDHVH GALLILNELL RCSNATWEKK YTTLMQKLDA EQDISDEMTS LSSKVQNSWT
AQHFPDDKSQ QTLVYESSIC KKLIEEQYEK ICSDVMAQQI SRAHNVHQML LLMIPRLAAF
NREAFAKRHL KSTINHLITF LRGREKEKAM AFTTLGLICV AVESDVQQYL GRIIEIIKLT
LPLKDTPKKR NGSDTPLFNC VTLLGFAMKE DVANEVKELL DPMCATGLSP QLTTCFKELS
QNLPSLKKEI TDRLLNMLSL ILRKKPYAPN NGENQIVHMF TTAMLVEPHD ASKLVLALRT
LGSFDFEWNN TLMSFIRRCT DHYLLSEQHD IRIEAVKTAS KLLIKAVERC AQTNSRTLTV
IVDESLGKLL SVGRSDFDHE VRYRVLEIFT NPVFDRYLAV EEHLNCLFVA INDSNNDVSE
LALCLVGRLS NINPSYTIPT LRQLFVQVLM ELQHSESTRN KEQALRMVNN IISHAPRITR
QFVDTILNVL VPKLKAEADN PTMVATILKA IGDLAEVNGG GTALNKWLPE LMSIQINILS
DPNQPEKRSV ALWSFGQVVG ATGHVVTPYM EYPHLMDMML NFLKTEQQPR ERRETIRVLG
LLGALDPYKH KVNQGLIDFQ TVSTLIPVSD STNENIDINI SDMVVNMSPL ILDEFYPAIV
LTSLMRMLRD PMLTQHHTSV VHSVTFIFQS LGIKCVPYVS RVTPCLLNVI RTTDNSTFRE
FLLTQLAQLI SVVKIQIRNY LEDIFDIIKE YWTPNSQLQP TLIMLVEHIT VAIGPEFKVY
LRKILPNILR VLKYDNSKDR VLTEKLLLTI QKFENNLDDV LLSIVPAVTA LFDGRNIPLS
ISKLAMETME HLCMYLYFRP FSAVIIQALA KVLDNNPSLR QTAMNTLCAL IVQLGREYID
YIPSVDRILI KHKIQCPNYI VLVTRLQAIS TLASDDDYLD ETRLRLRNQK TDVVGPGDIQ
TIQKLSLNVS NLRKCWSIKN IVSKEDWMEW LRQLSVAFLT ESNSPAIRAC SSLAQNYPQL
ASELFNAAFM SCWTELDDKS RKELVQALEH ALTVPDTPEL ALAVLNLAEF LEHCEKGSLP
IPIKLLGDTA INCRAYAKAL YYKEQEYKRN PSKQVIEALI HINNKLQRNE ASNGLLEKVI
TQKKSGETSL NVHVRWYEKL HNWDQALELY NKKLEVEPLD EDSRLGMMRC LEALGEWRKI
YNLTSEQWDN ASEDVRKKSA KIAAAASWGL QEWDSMRKYV EVISEDSHEG AFYRAILAIH
EGHWPESRHY IDSARSLLDL ELTAVVGESY QRAYGALVNA QLLTELEEVV TYKLVEERRN
PIRKCWWLRL QGGQRLVEDW RKMLQIRSLV MSPREDFQTW LKFASLCRKT GAFNQAHKIV
LSILGCDPIT NPDVLLRMQD PRIVLAYSKN LWDAGNKRYA YDVLQRFLDN SEPDNDEHCR
LLARCHLKLG SWCESLQEIN ELSIPEILRN YESATLLAPD WYKACHAWAC MNFETVLFYK
QQDNISESSL AGGSGEKKVS RTDFINTHTI PAIEGFFKSI SLSNGSALQD TLRLLTLWFD
HGHHPAIYDA LFEGIRQIDV KIWLQVIPQL IARIDSPRSL VAKLVHILLI DIGKLHPQAL
VYPLTVATKS SFVTRKNAAN YILKTMCAHS QNLVNEAAII SEELIKVAIL WHDQVFIALD
EASSEKDYRG MFKTLDKIHA MLDRPPETLK EVSFLQMYGR DLQEAHRWME LYKESGENRY
LNEAWDLYYH VVRRITNQFR SLTSLELQYV SKRLHTCKDL ELAVPGSYVP NEKVIRISHI
HSHLQVIKSK QRPRRLTIQG SDGKQYMFLL KGHEDLRQDE RVMQLFGLVN TLLQADTNTY
RHDLAIQRYA VIPLSPNSGL IGWVPQCDTL YNLISDYRDK KSNKMALSTE QQIMLRMASD
YQKLMLKHKV EVFEYTLSQT PGNDLSRLLW LKSPSAEAWF ERRTNYTRSL AVMSMVGYIL
GLGDRHPSNI MLHRVTGKVL HIDFGDCFEV TQSREKFPEK IPFRLTRMLI NAMEVRLYYS
EKDYRGMFKT LDKIHAMLDR PPETLKEVSF LQMYGRDLQE AHRWMELYKE SGENRYLNEA
WDLYYHVVRR ITNQFRSLTS LELQYVSKRL HTCKDLELAV PGSYVPNEKV IRISHIHSHL
QVIKSKQRPR RLTIQGSDGK QYMFLLKGHE DLRQDERVMQ LFGLVNTLLQ ADTNTYRHDL
AIQRYAVIPL SPNSGLIGWV PQCDTLYNLI SDYRDKKSNK MALSTEQQIM LRMASDYQKL
MLKHKVEVFE YTLSQTPGND LSRLLWLKSP SAEAWFERRT NYTRSLAVMS MVGYILGLGD
RHPSNIMLHR VTGKVLHIDF GDCFEVTQSR EKFPEKIPFR LTRMLINAME VTGIEGTYRS
TCESVMHVLH KHRDSVMAVL EAFVYDPLLN WRLVDNERHS LSESSFSSDI ESSYTLPSRS
RNHLHYESLE MPPEANLNKR ALSILNRIRD KLTGRDFPHV EAVVSVPKQV DLLIKQATSN
ENLCQCYIGW CPYW
//
