ID A0A2A4JUU1_HELVI Unreviewed; 1215 AA.
AC A0A2A4JUU1;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 24-JAN-2024, entry version 17.
DE RecName: Full=DNA mismatch repair protein {ECO:0000256|PIRNR:PIRNR037677};
GN ORFNames=B5V51_12012 {ECO:0000313|EMBL:PCG75253.1};
OS Heliothis virescens (Tobacco budworm moth).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Noctuoidea;
OC Noctuidae; Heliothinae; Heliothis.
OX NCBI_TaxID=7102 {ECO:0000313|EMBL:PCG75253.1, ECO:0000313|Proteomes:UP000218220};
RN [1] {ECO:0000313|EMBL:PCG75253.1, ECO:0000313|Proteomes:UP000218220}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HvINT- {ECO:0000313|EMBL:PCG75253.1};
RC TISSUE=Whole body {ECO:0000313|EMBL:PCG75253.1};
RA Fritz M.L., Deyonke A.M., Papanicolaou A., Micinski S., Westbrook J.,
RA Gould F.;
RT "Contemporary evolution of a Lepidopteran species, Heliothis virescens, in
RT response to modern agricultural practices.";
RL Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the post-replicative DNA mismatch repair system
CC (MMR). {ECO:0000256|PIRNR:PIRNR037677, ECO:0000256|RuleBase:RU003756}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|PIRNR:PIRNR037677, ECO:0000256|RuleBase:RU003756}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PCG75253.1}.
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DR EMBL; NWSH01000620; PCG75253.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2A4JUU1; -.
DR Proteomes; UP000218220; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11361:SF148; DNA MISMATCH REPAIR PROTEIN MSH6; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 2.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 2.
DR SMART; SM00534; MUTSac; 2.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 2.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PIRNR:PIRNR037677};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|PIRNR:PIRNR037677};
KW DNA repair {ECO:0000256|PIRNR:PIRNR037677, ECO:0000256|RuleBase:RU003756};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PIRNR:PIRNR037677};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|PIRNR:PIRNR037677};
KW Reference proteome {ECO:0000313|Proteomes:UP000218220}.
FT DOMAIN 871..887
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT DOMAIN 1064..1080
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT REGION 1..59
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..19
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1215 AA; 135944 MW; 896472FBE0F87740 CRC64;
MDTSEVEKPS MEKKLQDSFK YEPNQSPKAK KPSKPANKPS SSEKPTTSPP KPVEEKPIAD
EGNWTHCKLD WLKPQKIRDA QKRRPDHPEY NPSTLFVPPE FYKDQTPAHR QWWEMKSSHF
DCVLFFKVGK FYELYHMDAA VGVNELGFSY MKGEFAHSGF PESAYGRMAS TLVSKGYKVA
RVEQTETPDM MQERCRKTGK NSKWDKVVRR EICQVTMRGA QICGLQDNGP AEPTAAYMMA
IAEEESNGSS TYGICFVDTS IGLFHLGQFQ DDKHSSRLLT TLAHYPPALI IYDRKTSART
TKLLSTHCHS ARREPQTLWT PDKTLKTLAE KYYRTNADGE WPEGITPFLH EGDALGLTPA
ANCYLAIKAL GGVVSCLTDC LLDIQILGMN QFTSYSPPDV LNKTLSQEVK VENRWEGGST
MVLDAITLRN LRIVQDEGCL YDRLNFCSTH MGKRLLYQWV CAPSCNISVI KERQNAVKAL
FENQELCQDA KSILTTLPDL ERLLAKVHAL GNLKRSKQHP DARAIFYEEK TYSKRKVLDF
ISVLNGFTAA LKLVELFSDA DAKLLKRIMQ FHPDGKYPDY RETLKFFKEA FNQKEAEKEG
RILPGEGVDQ EYDNTLKLIQ EIEAELKEYL SEQEKYFKCR LSYVGTDKKR YQIEVPVNAA
AKAGADYNLE GARKGFKRFS TSDTKDFLAR MIAAEEQKTN VLKDLSRRIF EKFSSHYGQW
ETAVQCLATL DILLAFTEFA RQQSGDVCLP EVTYDEEQKP YLNIVEGRHP CIPNIADFIP
NDTQLGTGDS SLLLLTGPNM GGKSTLMRQA GLITVLAHLG SYVPAEQCKL SLVDRIFTRL
GASDDIFSGQ STFLVEMNET AAIVTHATVH SLVLLDELGR GTSTYDGTAI ASGVCVELAS
RGCRVIFSTH YHSLVHHLSS HPGIMLGHMA CMVETDESTP DSEDHIPEET ITFLYKLSPG
ACPKSYGFNA ARLAGIPKEI TLRAHQISKN LEKEATCVRA FRDIVKMQKP NDGSYVPAEQ
CKLSLVDRIF TRLGASDDIF SGQSTFLVEM NETAAIVTHA TVHSLVLLDE LGRGTSTYDG
TAIASGVCVE LASRGCRVIF STHYHSLVHH LSSHPGIMLG HMACMVETDE STPDSEDHIP
EETITFLYKL SPGACPKSYG FNAARLAGIP KEITLRAHQI SKNLEKEATC VRAFRDIVKM
QKPNDVRAML AALSI
//
