ID A0A2A4JW50_HELVI Unreviewed; 745 AA.
AC A0A2A4JW50;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 22-FEB-2023, entry version 12.
DE RecName: Full=Transporter {ECO:0000256|RuleBase:RU003732};
GN ORFNames=B5V51_10709 {ECO:0000313|EMBL:PCG75918.1};
OS Heliothis virescens (Tobacco budworm moth).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Noctuoidea;
OC Noctuidae; Heliothinae; Heliothis.
OX NCBI_TaxID=7102 {ECO:0000313|EMBL:PCG75918.1, ECO:0000313|Proteomes:UP000218220};
RN [1] {ECO:0000313|EMBL:PCG75918.1, ECO:0000313|Proteomes:UP000218220}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HvINT- {ECO:0000313|EMBL:PCG75918.1};
RC TISSUE=Whole body {ECO:0000313|EMBL:PCG75918.1};
RA Fritz M.L., Deyonke A.M., Papanicolaou A., Micinski S., Westbrook J.,
RA Gould F.;
RT "Contemporary evolution of a Lepidopteran species, Heliothis virescens, in
RT response to modern agricultural practices.";
RL Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the sodium:neurotransmitter symporter (SNF) (TC
CC 2.A.22) family. {ECO:0000256|ARBA:ARBA00006459,
CC ECO:0000256|RuleBase:RU003732}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PCG75918.1}.
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DR EMBL; NWSH01000515; PCG75918.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2A4JW50; -.
DR STRING; 7102.A0A2A4JW50; -.
DR Proteomes; UP000218220; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
DR CDD; cd11497; SLC6sbd_SERT-like; 1.
DR InterPro; IPR000175; Na/ntran_symport.
DR InterPro; IPR037272; SNS_sf.
DR PANTHER; PTHR11616; SODIUM/CHLORIDE DEPENDENT TRANSPORTER; 1.
DR PANTHER; PTHR11616:SF312; TRANSPORTER; 1.
DR Pfam; PF00209; SNF; 1.
DR PRINTS; PR00176; NANEUSMPORT.
DR SUPFAM; SSF161070; SNF-like; 1.
DR PROSITE; PS00610; NA_NEUROTRAN_SYMP_1; 1.
DR PROSITE; PS50267; NA_NEUROTRAN_SYMP_3; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000218220};
KW Symport {ECO:0000256|ARBA:ARBA00022847, ECO:0000256|RuleBase:RU003732};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003732};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003732}.
FT TRANSMEM 217..238
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 259..286
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 359..377
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 386..407
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 435..456
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 468..491
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 527..552
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 572..596
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 602..625
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 646..666
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 686..705
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 1..132
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 37..72
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 118..132
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 745 AA; 82670 MW; 06E9C681308B4230 CRC64;
MAGMPVLGNS VGAGELRDNS REASNRSSSS GSRRGSSPHH AQEHETCDAT VHKSDITRTR
PSSYEREYHD KVPTMASLSG GGVVTHTAPS YEEQRANPAL LSRGASGTPG GRSVRDDGYC
SASSTPRAFD NKSTKGSVVT LSCYKKEPKI QIEEECFYSE TSKKLRTNSI KPEEGDGRET
WGTGADFLLS IIGFAVDLAN VWRFPYLCYR NGGGAFLIPY TLMLVFGAVP LFYMELILGQ
YNRQGPITLW KICPLFKGVG FCAVMVAFYV SFYYNVIIGW ALYFLISSAR SELPWVHCDN
SWNTEQCWDS GRINGTSNRT DVRYQGPLSH FTPASEFFHR AVLEMQHSEG LNDLGFPKWQ
LAICLGLVYV TLYLSLFKGV KSSGKVVWLT ATMPYVVLSI LLARGLLLPG ATRGIAYYLQ
PELTRLKDTQ VWVDAAVQIF YSVGAGFGVH LSYASYNTFH NNCYRDCLVT TLVNCFTSFF
SGFVIFTYLG FMSYKQGVPI SSVATEGPGL VFQVYPEAVA TLPGASLWAM LFFFMLIMLG
LDSGMGGLEC VITGLLDQAR ACGAAWLRRE HFTLLVVCVS FCVACINVTP GGIYMFHLLD
TYAAGISLLC SALFEAVAVS WFYGLKRFSD DVEEMLGFRP GLYWRICWKF VSPTFIIGVV
VFGLLYQQPL QYQHYTYPPW AVVLGWGLAC SSILMIPVIA VYKLLSTPGT FRQRLACCIS
PESEHEAIRG GAPVSRFTWK HWLYV
//
