ID A0A2A4JXS4_HELVI Unreviewed; 261 AA.
AC A0A2A4JXS4;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 24-JAN-2024, entry version 8.
DE RecName: Full=Fibroin light chain {ECO:0000256|PIRNR:PIRNR005765};
DE Short=Fib-L {ECO:0000256|PIRNR:PIRNR005765};
DE AltName: Full=L-fibroin {ECO:0000256|PIRNR:PIRNR005765};
GN ORFNames=B5V51_8632 {ECO:0000313|EMBL:PCG76817.1};
OS Heliothis virescens (Tobacco budworm moth).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Noctuoidea;
OC Noctuidae; Heliothinae; Heliothis.
OX NCBI_TaxID=7102 {ECO:0000313|EMBL:PCG76817.1, ECO:0000313|Proteomes:UP000218220};
RN [1] {ECO:0000313|EMBL:PCG76817.1, ECO:0000313|Proteomes:UP000218220}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HvINT- {ECO:0000313|EMBL:PCG76817.1};
RC TISSUE=Whole body {ECO:0000313|EMBL:PCG76817.1};
RA Fritz M.L., Deyonke A.M., Papanicolaou A., Micinski S., Westbrook J.,
RA Gould F.;
RT "Contemporary evolution of a Lepidopteran species, Heliothis virescens, in
RT response to modern agricultural practices.";
RL Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: It is likely that the major role of L-chain is to prevent the
CC retention of H-chain in ER by forming the disulfide linkage.
CC {ECO:0000256|PIRNR:PIRNR005765}.
CC -!- SUBUNIT: Silk fibroin elementary unit consists in a disulfide-linked
CC heavy and light chain and a p25 glycoprotein in molar ratios of 6:6:1.
CC This results in a complex of approximately 2.3 MDa.
CC {ECO:0000256|PIRNR:PIRNR005765}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|PIRNR:PIRNR005765}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PCG76817.1}.
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DR EMBL; NWSH01000381; PCG76817.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2A4JXS4; -.
DR Proteomes; UP000218220; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR InterPro; IPR008660; L-fibroin.
DR Pfam; PF05849; L-fibroin; 1.
DR PIRSF; PIRSF005765; L-fibroin; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000218220};
KW Secreted {ECO:0000256|PIRNR:PIRNR005765}; Signal {ECO:0000256|SAM:SignalP};
KW Silk protein {ECO:0000256|PIRNR:PIRNR005765}.
FT SIGNAL 1..16
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 17..261
FT /note="Fibroin light chain"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5012697887"
SQ SEQUENCE 261 AA; 26984 MW; D9F73CB46B18F986 CRC64;
MLPIVLVLLV ATSALAAPGV NLSIRNVNEV VPPRHNGRAV SAFLTNQAFE NIDGGDTVPY
VLNFQQVVDD LANQGDKSSQ ALAAGQVIAI LGSLSTGIPG DACAPANFID SYVASLRNGN
SVAPALGKFV GAIKQHIDQI VQYLNNPNQL KNAVGPRGNC NGGGRNYQFE AAWDAILSNA
SGASAGLVNE QYCAAKRLYS AFGLQSSSLG AYVTAVSLPP VNRVLQDALE PVAKFVASLS
SGNYAAAAAG AKNALDNALR Y
//
