ID A0A2A4K1U2_HELVI Unreviewed; 747 AA.
AC A0A2A4K1U2;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=TIR domain-containing protein {ECO:0000259|PROSITE:PS50104};
DE Flags: Fragment;
GN ORFNames=B5V51_5653 {ECO:0000313|EMBL:PCG77996.1};
OS Heliothis virescens (Tobacco budworm moth).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Noctuoidea;
OC Noctuidae; Heliothinae; Heliothis.
OX NCBI_TaxID=7102 {ECO:0000313|EMBL:PCG77996.1, ECO:0000313|Proteomes:UP000218220};
RN [1] {ECO:0000313|EMBL:PCG77996.1, ECO:0000313|Proteomes:UP000218220}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HvINT- {ECO:0000313|EMBL:PCG77996.1};
RC TISSUE=Whole body {ECO:0000313|EMBL:PCG77996.1};
RA Fritz M.L., Deyonke A.M., Papanicolaou A., Micinski S., Westbrook J.,
RA Gould F.;
RT "Contemporary evolution of a Lepidopteran species, Heliothis virescens, in
RT response to modern agricultural practices.";
RL Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC {ECO:0000256|ARBA:ARBA00009634}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PCG77996.1}.
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DR EMBL; NWSH01000254; PCG77996.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2A4K1U2; -.
DR STRING; 7102.A0A2A4K1U2; -.
DR Proteomes; UP000218220; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR GO; GO:0002224; P:toll-like receptor signaling pathway; IEA:InterPro.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 3.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR017241; Toll-like_receptor.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR24365:SF550; TOLL-9, ISOFORM A; 1.
DR PANTHER; PTHR24365; TOLL-LIKE RECEPTOR; 1.
DR Pfam; PF13855; LRR_8; 2.
DR Pfam; PF01582; TIR; 1.
DR PRINTS; PR01537; INTRLKN1R1F.
DR SMART; SM00369; LRR_TYP; 4.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS50104; TIR; 1.
PE 3: Inferred from homology;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000218220};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 541..560
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 594..733
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:PCG77996.1"
SQ SEQUENCE 747 AA; 85497 MW; F2CF6D162A86B0BE CRC64;
LLNCFLACTC GLPPKPPKCL TGYMTDVQNW VDENGRLIPK SGNMNNAIDL STTANPVQVL
NEKLNFSRRR QVVRYLSLAK CQLTRVPPIF QIRDNEMRPL AMMLEYMTLY GNNFLGMSTA
GEHYTLSFNA TGTTVMNLSN SPQRQVVSVW SSGFTAVNFP NLKELDLRSC SIQTLEKNLF
KGMPNLTALY IGENEIHFIS SSAFYGLKNL VHLDLSRNQA FDENGNPKNL ATDNYLVFNY
LENLVSLDLS HTKLTLRNLG LLKSLGKSVK SLSLCDTGLN VLQDDIFNCT SLNMLDLSYN
SGILNNQKPL RGLEKTLLAL YAREINLQTL NQFQNFSQLL VLQLTGNEIN NVDVSVIKTL
KSLRILNLNK NRLNSWFEPL FSTIPSLHVL SLQDNNINVI TEQMVDDLAN VSYLALSGNF
MVCNCHAKDF YKMAAKNEKN NTETYIDLPE DLLHRNIYSY YNDLIKNRTK VFGGLEDCEN
QCVDDIGDSG IFRLLDYSPQ NYVCLHVPES KTIFISEVYS CGRLAREVNY DQELKGSRVK
LLVLLLIPCI LLPVGVIFAF RRRIKYFFIT LRNSAMLSLI NKKDAVDGKN NTIFNYDVFV
SYCNEDRGWV LDHLLPHMEA ECSISACLHE RDFLVGLSIL ENIVSCMDRS RSIMLILSQR
FLLSQWCQFE MHLAQHRLLE TRREDLTLVL LEDIPRRLRP NTLHYLMMTK TYIVWPKDES
ERPIFWKRLK KTLIAQKNKP TENTSLA
//
