ID A0A2A4KFP7_9ACTN Unreviewed; 997 AA.
AC A0A2A4KFP7;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Hyaluronidase {ECO:0000313|EMBL:PCG82613.1};
GN ORFNames=CIB93_28905 {ECO:0000313|EMBL:PCG82613.1};
OS Streptomyces sp. WZ.A104.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=2023771 {ECO:0000313|EMBL:PCG82613.1, ECO:0000313|Proteomes:UP000217525};
RN [1] {ECO:0000313|EMBL:PCG82613.1, ECO:0000313|Proteomes:UP000217525}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WZ.A104 {ECO:0000313|EMBL:PCG82613.1,
RC ECO:0000313|Proteomes:UP000217525};
RA Xu L., He S., Yan X.;
RT "Isolation and Genomic Analysis of a Bioactive Actinomycete Associated with
RT Cyanobacterium Lyngbya cf. aestuarii.";
RL Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000217525}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WZ.A104 {ECO:0000313|Proteomes:UP000217525};
RA Jiao Y., Han B.;
RL Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PCG82613.1}.
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DR EMBL; NWVL01000068; PCG82613.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2A4KFP7; -.
DR OrthoDB; 9760892at2; -.
DR Proteomes; UP000217525; Unassembled WGS sequence.
DR GO; GO:0016231; F:beta-N-acetylglucosaminidase activity; IEA:UniProt.
DR GO; GO:1901135; P:carbohydrate derivative metabolic process; IEA:UniProt.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:UniProt.
DR GO; GO:1901564; P:organonitrogen compound metabolic process; IEA:UniProt.
DR Gene3D; 3.30.379.10; Chitobiase/beta-hexosaminidase domain 2-like; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR Gene3D; 1.20.58.460; Hyaluronidase post-catalytic domain-like; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR000421; FA58C.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR InterPro; IPR029018; Hex-like_dom2.
DR InterPro; IPR015882; HEX_bac_N.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR049019; NagJ-like_helical.
DR InterPro; IPR011496; O-GlcNAcase_cat.
DR InterPro; IPR006311; TAT_signal.
DR PANTHER; PTHR13170; O-GLCNACASE; 1.
DR PANTHER; PTHR13170:SF16; PROTEIN O-GLCNACASE; 1.
DR Pfam; PF00754; F5_F8_type_C; 1.
DR Pfam; PF02838; Glyco_hydro_20b; 1.
DR Pfam; PF07555; NAGidase; 1.
DR Pfam; PF21774; NagJ_C; 1.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR SUPFAM; SSF55545; beta-N-acetylhexosaminidase-like domain; 1.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR SUPFAM; SSF140657; Hyaluronidase post-catalytic domain-like; 1.
DR PROSITE; PS50022; FA58C_3; 1.
DR PROSITE; PS51318; TAT; 1.
PE 4: Predicted;
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000217525};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..29
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 30..997
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5012201441"
FT DOMAIN 859..994
FT /note="F5/8 type C"
FT /evidence="ECO:0000259|PROSITE:PS50022"
FT REGION 40..68
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 862..902
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 45..62
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 997 AA; 105545 MW; 2F35DCC67522B451 CRC64;
MRIGRRRQAT AVAAAVIGGL LGSVSVAPAA TAAPVDPAIP VTGSAERSDS AQPPSVWPRP
QSIRSTGPAV PLGAEATLVA APDADPYAVE QTRSLLRGAG VRTLHESLPG SGPVVRLGGT
GAGEALRALR APDRADLPSG GYRIAVGRVA GRGTVALDGL GEDGLFHAVQ TLRQLVSGGS
VAGVTVRDWP GTAVRGLSEG FYGQPWTREE RLAQISFMGR TKQNRYLYAA GDDPYRLARW
REPYPADQRA GFRALAEQAR AEHVTLGWAL SPGQAMCMAS DQDVRALTKK IDAMWALGFR
VFQLQFQDVS YSEWHCDLDA ETFGSGPKAA ARAQARVAGA VARHLAEQHP DAAPLSVLPT
EFYQDGATDY RTALAAELDD RVQVAWTGVG VVPKTITGGE LAGARAAFRH PLVTMDNYPV
NDYAQDRIFL GPYTGRDPAV ASGSAALLAN AMEQPSASRI PLFTAADFAW NPKGYRPEES
WRAAIDDLAG GDAGARDALR ALAGNSAASV LGAQESAYLQ PLLDGFWKTR AAEAPARGRA
ARDLRAAFSV MRQAPERLKT PADGRLTDEV RPWTEQLARY GRAGELAVDL LQAQAAGDGA
AAWRAQLALE PLREEITASG ASVGKGVLDP FLDKVAKASA GWNGTDRAPG RVSKDAHSYT
VRLNGVRPVD AVTALAEPGS TGTGAVVEAH VPGEGWRALG QLSPSGWTQT AAKGLRADAV
RVTVPEAARN APPSYLNPPL PPSPAVVAGA PQVRALVPWF GDEPAATLDL ARRETDAEIG
GEPQRVAARL AGQRPAEVKG RLTAKAPEGI KVRVPKETTV PRGSRTEVPV DITVPADTPA
GEYEVPLAFG GQESTLTVRA FPRTGGPDLA RTAKASSSGD ETPDFPASAA SDGDPETRWS
SPVEDGAWWQ AELERPVRLG QVVLNWQDAY ASRYRIQVSA DGRTWRSAAT VREGRGGRES
VRMDAKDTRF VRVQGEGRAT QYGYSLWSVE AYAVADD
//
