ID A0A2A4M078_9BACT Unreviewed; 247 AA.
AC A0A2A4M078;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE RecName: Full=D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding domain-containing protein {ECO:0000259|Pfam:PF02826};
GN ORFNames=COC21_06530 {ECO:0000313|EMBL:PCH53310.1};
OS Verrucomicrobiales bacterium.
OC Bacteria; Verrucomicrobiota; Verrucomicrobiae; Verrucomicrobiales.
OX NCBI_TaxID=2026801 {ECO:0000313|EMBL:PCH53310.1, ECO:0000313|Proteomes:UP000219702};
RN [1] {ECO:0000313|Proteomes:UP000219702}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Tully B.J., Wheat C.G., Glazer B.T., Huber J.A.;
RT "A dynamic microbial community with high functional redundancy inhabits the
RT cold, oxic subseafloor aquifer.";
RL Submitted (AUG-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the D-isomer specific 2-hydroxyacid
CC dehydrogenase family. {ECO:0000256|ARBA:ARBA00005854}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PCH53310.1}.
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DR EMBL; NVQP01000133; PCH53310.1; -; Genomic_DNA.
DR Proteomes; UP000219702; Unassembled WGS sequence.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0016614; F:oxidoreductase activity, acting on CH-OH group of donors; IEA:UniProt.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR029753; D-isomer_DH_CS.
DR InterPro; IPR029752; D-isomer_DH_CS1.
DR InterPro; IPR006140; D-isomer_DH_NAD-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR42789; D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10090); 1.
DR PANTHER; PTHR42789:SF1; D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10090); 1.
DR Pfam; PF02826; 2-Hacid_dh_C; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00065; D_2_HYDROXYACID_DH_1; 1.
DR PROSITE; PS00670; D_2_HYDROXYACID_DH_2; 1.
DR PROSITE; PS00671; D_2_HYDROXYACID_DH_3; 1.
PE 3: Inferred from homology;
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002}.
FT DOMAIN 9..195
FT /note="D-isomer specific 2-hydroxyacid dehydrogenase NAD-
FT binding"
FT /evidence="ECO:0000259|Pfam:PF02826"
FT UNSURE 211
FT /note="E or Q"
FT /evidence="ECO:0000313|EMBL:PCH53310.1"
SQ SEQUENCE 247 AA; 26897 MW; 106CFC1FD9CC09AD CRC64;
MDEVADQAIG MLIACNRRFL RVERGLKESL EPWDCRAVEP VPRLAGATLG IVGLGRIGQA
TAQRAKAMRM RVIAHDPYLR PGIEKVFGVE XVXXXELLET SDAVSLHVPL TDETRQMIDA
DALGRMKPSA ILVNTARGAV VDTAALAAAL REGKIAGAGV DVLPAEPARA DEPLIQLWRD
ADESNVNLIL MPHTAFYSVE GLLEMRTKAA EEIVRAXRGX KLINCVNAQW LPEEMRDRVL
VGTPPTV
//
