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Database: UniProt
Entry: A0A2A4X829_9BACT
LinkDB: A0A2A4X829_9BACT
Original site: A0A2A4X829_9BACT 
ID   A0A2A4X829_9BACT        Unreviewed;       435 AA.
AC   A0A2A4X829;
DT   20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT   20-DEC-2017, sequence version 1.
DT   16-JAN-2019, entry version 9.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS01081161};
GN   ORFNames=COB21_00300 {ECO:0000313|EMBL:PCI78656.1};
OS   Candidatus Aerophobetes bacterium.
OC   Bacteria; Candidatus Aerophobetes.
OX   NCBI_TaxID=2030807 {ECO:0000313|EMBL:PCI78656.1};
RN   [1] {ECO:0000313|EMBL:PCI78656.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=NORP91 {ECO:0000313|EMBL:PCI78656.1};
RX   PubMed=29099490; DOI=.1038/ismej.2017.187;
RA   Tully B.J., Wheat C.G., Glazer B.T., Huber J.A.;
RT   "A dynamic microbial community with high functional redundancy
RT   inhabits the cold, oxic subseafloor aquifer.";
RL   ISME J. 12:1-16(2018).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|RuleBase:RU000577,
CC       ECO:0000256|SAAS:SAAS00756121}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|SAAS:SAAS01082709}.
CC   -!- SIMILARITY: Belongs to the DnaA family.
CC       {ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:PCI78656.1}.
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DR   EMBL; NVUK01000002; PCI78656.1; -; Genomic_DNA.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:InterPro.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:InterPro.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:InterPro.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   Gene3D; 3.30.300.180; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR038454; DnaA_N_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|RuleBase:RU000577,
KW   ECO:0000256|SAAS:SAAS00756129};
KW   Cytoplasm {ECO:0000256|SAAS:SAAS01082702};
KW   DNA replication {ECO:0000256|RuleBase:RU004227,
KW   ECO:0000256|SAAS:SAAS00756116};
KW   DNA-binding {ECO:0000256|RuleBase:RU000577,
KW   ECO:0000256|SAAS:SAAS01082706};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU000577,
KW   ECO:0000256|SAAS:SAAS00756117}.
FT   DOMAIN      136    262       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      344    412       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
SQ   SEQUENCE   435 AA;  50111 MW;  2B2C1300CDDD9E9C CRC64;
     MNQWLKFLKY LETRFDVNTI KQWVTPLKVV NFDARNIYLK AENQFQIAWF NEHIKQLCSE
     ILLSSAGLPI KVHIICDKGL ENKPTVAHKI NENNFSPDFC DPLFTFDNFL AANKTLLSCQ
     ILKDLILNEK NQNKDDNNPI FIYGPPSSGK THLLTAIALT LKAQGNKVCF VHALTFSKHV
     IHAFRGSLLQ EFRQTYRNMD VLIIDDIHLL KRKTSSQEEL FHTFNSLHTR KKRIIVSSNV
     IPSHLEEIEE RLTSRFEWGI SLAIEKPPSE ILKQILGIKA HQLNLPLSHE LRAWLLSQFL
     TPASLASALS TLCLYHHSNS PLEKTRAEFY LKDLILLEKS KTLTLDSVVR KVCSYYGIKN
     EDVLGRSQTK ETSLPRQISM YLCREKIKTP YIQLGDFFNR DHSTVMTSVK SIKLRLKRKE
     PEVLTAIDKI SQALL
//
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