ID   A0A2A5BDM9_9RICK        Unreviewed;       429 AA.
AC   A0A2A5BDM9;
DT   20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT   20-DEC-2017, sequence version 1.
DT   13-SEP-2023, entry version 20.
DE   RecName: Full=Citrate synthase {ECO:0000256|ARBA:ARBA00022134, ECO:0000256|PIRNR:PIRNR001369};
GN   Name=gltA {ECO:0000313|EMBL:PCJ29278.1};
GN   ORFNames=COA94_01950 {ECO:0000313|EMBL:PCJ29278.1};
OS   Rickettsiales bacterium.
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Rickettsiales.
OX   NCBI_TaxID=2026788 {ECO:0000313|EMBL:PCJ29278.1, ECO:0000313|Proteomes:UP000218523};
RN   [1] {ECO:0000313|Proteomes:UP000218523}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Tully B.J., Wheat C.G., Glazer B.T., Huber J.A.;
RT   "A dynamic microbial community with high functional redundancy inhabits the
RT   cold, oxic subseafloor aquifer.";
RL   Submitted (AUG-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=acetyl-CoA + H2O + oxaloacetate = citrate + CoA + H(+);
CC         Xref=Rhea:RHEA:16845, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16452, ChEBI:CHEBI:16947, ChEBI:CHEBI:57287,
CC         ChEBI:CHEBI:57288; EC=2.3.3.16;
CC         Evidence={ECO:0000256|ARBA:ARBA00000308,
CC         ECO:0000256|RuleBase:RU003370};
CC   -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate
CC       from oxaloacetate: step 1/2. {ECO:0000256|ARBA:ARBA00004751,
CC       ECO:0000256|RuleBase:RU003370}.
CC   -!- SIMILARITY: Belongs to the citrate synthase family.
CC       {ECO:0000256|ARBA:ARBA00010566, ECO:0000256|PIRNR:PIRNR001369,
CC       ECO:0000256|RuleBase:RU003406}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PCJ29278.1}.
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DR   EMBL; NVVL01000007; PCJ29278.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2A5BDM9; -.
DR   UniPathway; UPA00223; UER00717.
DR   Proteomes; UP000218523; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0004108; F:citrate (Si)-synthase activity; IEA:InterPro.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniPathway.
DR   CDD; cd06114; EcCS_like; 1.
DR   Gene3D; 2.20.28.60; -; 1.
DR   Gene3D; 1.10.580.10; Citrate Synthase, domain 1; 1.
DR   Gene3D; 1.10.230.10; Cytochrome P450-Terp, domain 2; 1.
DR   InterPro; IPR016142; Citrate_synth-like_lrg_a-sub.
DR   InterPro; IPR016143; Citrate_synth-like_sm_a-sub.
DR   InterPro; IPR002020; Citrate_synthase.
DR   InterPro; IPR019810; Citrate_synthase_AS.
DR   InterPro; IPR024176; Citrate_synthase_bac-typ.
DR   InterPro; IPR036969; Citrate_synthase_sf.
DR   InterPro; IPR010953; Citrate_synthase_typ-I.
DR   NCBIfam; TIGR01798; cit_synth_I; 1.
DR   PANTHER; PTHR42871; CITRATE SYNTHASE; 1.
DR   PANTHER; PTHR42871:SF1; CITRATE SYNTHASE; 1.
DR   Pfam; PF00285; Citrate_synt; 1.
DR   PIRSF; PIRSF001369; Citrate_synth; 1.
DR   PRINTS; PR00143; CITRTSNTHASE.
DR   SUPFAM; SSF48256; Citrate synthase; 1.
DR   PROSITE; PS00480; CITRATE_SYNTHASE; 1.
PE   3: Inferred from homology;
KW   Acyltransferase {ECO:0000313|EMBL:PCJ29278.1};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PIRNR:PIRNR001369};
KW   Tricarboxylic acid cycle {ECO:0000256|ARBA:ARBA00022532,
KW   ECO:0000256|RuleBase:RU003370}.
FT   ACT_SITE        311
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001369-1"
FT   ACT_SITE        370
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001369-1"
SQ   SEQUENCE   429 AA;  48149 MW;  0AB963AC627B2B59 CRC64;
     MAGKEMTEEF AELKINNETY KLPIRKSSIG PDVVDVTKLY AETGYFTYDP GFMSTASCTS
     KITFIDGGKG VLRHRGYEIG DLANNKDFLE VSYLLLKGDL PNAKEYKGFK DEIIKHSLVN
     EQIRNIFGAF RHSAHPMAVV LSVVGSLSAF YHDTIDMNTA EGRELCAIRM IAKMPTISAM
     TYKYSLGQAF VYPDDELPFA ENFLHMMFAT PNKKYKVNPV LAKALDKIFI LHADHEQNAS
     TSTVRTSGSS GSNPFASVCA GITSLWGPAH GGANEAVINM LREIGTIKNI PKFIEKAKSK
     EDPFRLMGFG HRVYKNYDPR AAVLRDTCKE VLAELGQLKG NPTLEIAMEL ERIALNDQYF
     IDRKLYPNVD FYSGIIYQAM GIPSQMFTVL FALARTSGWI SQWKEMSEDV EFKITRPRQL
     YTGHVSRKV
//