ID A0A2A5QZG9_9EURY Unreviewed; 552 AA.
AC A0A2A5QZG9;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE SubName: Full=Branched-chain alpha-keto acid dehydrogenase subunit E2 {ECO:0000313|EMBL:PCR92227.1};
GN ORFNames=CP557_17835 {ECO:0000313|EMBL:PCR92227.1};
OS Natrinema ejinorense.
OC Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Natrialbales;
OC Natrialbaceae; Natrinema.
OX NCBI_TaxID=373386 {ECO:0000313|EMBL:PCR92227.1, ECO:0000313|Proteomes:UP000219689};
RN [1] {ECO:0000313|EMBL:PCR92227.1, ECO:0000313|Proteomes:UP000219689}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JCM 13890 {ECO:0000313|EMBL:PCR92227.1,
RC ECO:0000313|Proteomes:UP000219689};
RA Roh S.W., Kim Y.B., Kim J.Y.;
RT "Genome sequences of Natrinema ejinorence JCM 13890T.";
RL Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=(R)-lipoate; Xref=ChEBI:CHEBI:83088;
CC Evidence={ECO:0000256|ARBA:ARBA00001938};
CC -!- SIMILARITY: Belongs to the 2-oxoacid dehydrogenase family.
CC {ECO:0000256|ARBA:ARBA00007317}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PCR92227.1}.
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DR EMBL; NXNI01000001; PCR92227.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2A5QZG9; -.
DR OrthoDB; 56234at2157; -.
DR Proteomes; UP000219689; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0016746; F:acyltransferase activity; IEA:InterPro.
DR CDD; cd06849; lipoyl_domain; 1.
DR Gene3D; 2.40.50.100; -; 1.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR Gene3D; 4.10.320.10; E3-binding domain; 2.
DR InterPro; IPR001078; 2-oxoacid_DH_actylTfrase.
DR InterPro; IPR000089; Biotin_lipoyl.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR036625; E3-bd_dom_sf.
DR InterPro; IPR004167; PSBD.
DR InterPro; IPR011053; Single_hybrid_motif.
DR PANTHER; PTHR43178; DIHYDROLIPOAMIDE ACETYLTRANSFERASE COMPONENT OF PYRUVATE DEHYDROGENASE COMPLEX; 1.
DR PANTHER; PTHR43178:SF5; LIPOAMIDE ACYLTRANSFERASE COMPONENT OF BRANCHED-CHAIN ALPHA-KETO ACID DEHYDROGENASE COMPLEX, MITOCHONDRIAL; 1.
DR Pfam; PF00198; 2-oxoacid_dh; 1.
DR Pfam; PF00364; Biotin_lipoyl; 1.
DR Pfam; PF02817; E3_binding; 1.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 1.
DR SUPFAM; SSF47005; Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex; 1.
DR SUPFAM; SSF51230; Single hybrid motif; 1.
DR PROSITE; PS50968; BIOTINYL_LIPOYL; 1.
DR PROSITE; PS51826; PSBD; 1.
PE 3: Inferred from homology;
FT DOMAIN 2..77
FT /note="Lipoyl-binding"
FT /evidence="ECO:0000259|PROSITE:PS50968"
FT DOMAIN 137..174
FT /note="Peripheral subunit-binding (PSBD)"
FT /evidence="ECO:0000259|PROSITE:PS51826"
FT REGION 80..271
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 286..323
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 137..151
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 171..233
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 255..271
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 552 AA; 58506 MW; 02595C7F13AF31A1 CRC64;
MVREFELPDV GEGVAEGELV SWLVEAGDEV TEDQPVAEVE TDKALVEVPA PVDGTVRELH
VEEGEVVPVG TVIISFDVEG EESEAPRASE NANGEAVSEG AAAPTESEQE TTSEPAGDPG
ATGADTEAVA PPDDRVFAPP RVRRMAREEG VDLSRIQGSG PGGRITAADV QAATGDSSGE
PAGSQSQSAG AAASEAASGT ADSTGRSAGA SAAEETTPED ATASSSTGRP ETPTRVESAD
RERTLAAPAT RRIAQEEGVD IDAVPATEER DGEAFVTPEA IQEYADAQRQ AQEADREAVE
AGESVGTKGA QFAEGERERR EPFTGVRKTI ADAMVESKYS APHVTHHDEV DVTELVAARE
DLKPRAEERG IRLTYMPFIM KAVVAALKEY PEMNAVIDEE NEEIVYRDYY NIGVATATDV
GLMVPVVEDA DRKGLLQLSS EMNEVVQKAR DRTISPDELR GSTFTITNVG GIGGEYATPI
INYPEAGILA IGEIKRKPRV VTDENGSESI EPRSVLTLSL SFDHRLIDGA VGAAFTNTVM
EYLENPSLLL LE
//
