ID A0A2A5RJY4_9LACT Unreviewed; 225 AA.
AC A0A2A5RJY4;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE SubName: Full=Deoxynucleoside kinase {ECO:0000313|EMBL:PCR99447.1};
GN ORFNames=RT41_GL001823 {ECO:0000313|EMBL:PCR99447.1};
OS Lactococcus fujiensis JCM 16395.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC Lactococcus.
OX NCBI_TaxID=1291764 {ECO:0000313|EMBL:PCR99447.1, ECO:0000313|Proteomes:UP000218181};
RN [1] {ECO:0000313|EMBL:PCR99447.1, ECO:0000313|Proteomes:UP000218181}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JCM 16395 {ECO:0000313|EMBL:PCR99447.1,
RC ECO:0000313|Proteomes:UP000218181};
RA Sun Z., Zhong Z., Liu W., Zhang W., Zhang H.;
RT "Draft genome sequences of 10 type strains of Lactococcus.";
RL Submitted (DEC-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the DCK/DGK family.
CC {ECO:0000256|ARBA:ARBA00007420}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PCR99447.1}.
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DR EMBL; JXJU01000008; PCR99447.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2A5RJY4; -.
DR STRING; 1291764.GCA_001311235_01566; -.
DR Proteomes; UP000218181; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0019136; F:deoxynucleoside kinase activity; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd01673; dNK; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR002624; DCK/DGK.
DR InterPro; IPR031314; DNK_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR10513; DEOXYNUCLEOSIDE KINASE; 1.
DR PANTHER; PTHR10513:SF15; NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 10, MITOCHONDRIAL; 1.
DR Pfam; PF01712; dNK; 1.
DR PIRSF; PIRSF000705; DNK; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|PIRSR:PIRSR000705-3};
KW Kinase {ECO:0000313|EMBL:PCR99447.1};
KW Nucleotide-binding {ECO:0000256|PIRSR:PIRSR000705-3};
KW Reference proteome {ECO:0000313|Proteomes:UP000218181};
KW Transferase {ECO:0000313|EMBL:PCR99447.1}.
FT DOMAIN 14..216
FT /note="Deoxynucleoside kinase"
FT /evidence="ECO:0000259|Pfam:PF01712"
FT ACT_SITE 88
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000705-1"
FT BINDING 18..26
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR000705-3"
FT BINDING 42
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000705-2"
FT BINDING 54
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000705-2"
FT BINDING 65
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000705-2"
FT BINDING 89
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000705-2"
FT BINDING 94
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000705-2"
FT BINDING 150..154
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR000705-3"
FT BINDING 159
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000705-2"
SQ SEQUENCE 225 AA; 26207 MW; 71B06AE5A65EAC82 CRC64;
MCWFNLEEEN TILIVLAGTI GAGKSSLAKA LGEHLGTEVF YEAVDNNPVL DLYYEDPKKY
AFLLQIYFLN KRFESIKMAY RQDNNVLDRS IFEDELFLTL NYKNGNVTKT ELDIYKDLLA
NMLEELEGMP KKRPDLLVYI DVSFETMLSR IAQRGRSFEQ VESQPGLEEY YNQVHGEYPE
WYENYDVSPK IKIDGDSIDF VNNPEDLEAV LQQIDDRLRK LDLLA
//
