ID A0A2A5YFA4_9SPHN Unreviewed; 372 AA.
AC A0A2A5YFA4;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=beta-lactamase {ECO:0000256|ARBA:ARBA00012865};
DE EC=3.5.2.6 {ECO:0000256|ARBA:ARBA00012865};
GN ORFNames=CNE89_15045 {ECO:0000313|EMBL:PDH63094.1};
OS Sphingomonadaceae bacterium MED-G03.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Sphingomonadales;
OC Sphingomonadaceae.
OX NCBI_TaxID=1986231 {ECO:0000313|EMBL:PDH63094.1, ECO:0000313|Proteomes:UP000219365};
RN [1] {ECO:0000313|EMBL:PDH63094.1, ECO:0000313|Proteomes:UP000219365}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MED-G03 {ECO:0000313|EMBL:PDH63094.1};
RA Haro-Moreno J.M., Lopez-Perez M., De La Torre J., Picazo A., Camacho A.,
RA Rodriguez-Valera F.;
RT "Fine stratification of microbial communities through a metagenomic profile
RT of the photic zone.";
RL Submitted (AUG-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a beta-lactam + H2O = a substituted beta-amino acid;
CC Xref=Rhea:RHEA:20401, ChEBI:CHEBI:15377, ChEBI:CHEBI:35627,
CC ChEBI:CHEBI:140347; EC=3.5.2.6;
CC Evidence={ECO:0000256|ARBA:ARBA00001526};
CC -!- SIMILARITY: Belongs to the class-A beta-lactamase family.
CC {ECO:0000256|ARBA:ARBA00009009}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PDH63094.1}.
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DR EMBL; NTKY01000068; PDH63094.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2A5YFA4; -.
DR Proteomes; UP000219365; Unassembled WGS sequence.
DR GO; GO:0008800; F:beta-lactamase activity; IEA:UniProtKB-EC.
DR GO; GO:0030655; P:beta-lactam antibiotic catabolic process; IEA:InterPro.
DR GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR045155; Beta-lactam_cat.
DR InterPro; IPR000871; Beta-lactam_class-A.
DR PANTHER; PTHR35333; BETA-LACTAMASE; 1.
DR PANTHER; PTHR35333:SF3; BETA-LACTAMASE2 DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF13354; Beta-lactamase2; 1.
DR PRINTS; PR00118; BLACTAMASEA.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
PE 3: Inferred from homology;
KW Antibiotic resistance {ECO:0000256|ARBA:ARBA00023251};
KW Hydrolase {ECO:0000313|EMBL:PDH63094.1}.
FT DOMAIN 79..333
FT /note="Beta-lactamase class A catalytic"
FT /evidence="ECO:0000259|Pfam:PF13354"
SQ SEQUENCE 372 AA; 39733 MW; 4E84345F913518EF CRC64;
MPPLTRSPLA RSIPTRFGAP RVRASRLAAA LAGFGLFFAP LPSADAFGPP PRPLVEQTAQ
AKLLAEFERF AALSDGTVGI AVRDLQTGET QSFNGDTLFP MASAYKVAVA GRIFALVDAG
ELRLDDQLAL DPALASEGGI AWMFSRPGAA LSVQRLLELM LQKSDNNATD VLVARAGGPQ
AITRFVTGLG VNGLRVDSDT AHLLYRAMGI HPSSGSFRHN ADAARRADPM IVTRDMRDLP
NLSFATEIED TSTPRAMLDL LSAYESGRAL SADSTQRLFT IMAHCETGKH RIVGMLPPGT
AVAHKTGSLN GTGNDVGVVR LPDGRRFAVV AFVMKDGKGH KARDRIIAEA ARAAYDYFLY
APERAHGSTH KS
//
