ID A0A2A5YJS4_9SPHN Unreviewed; 289 AA.
AC A0A2A5YJS4;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE SubName: Full=Oxidoreductase {ECO:0000313|EMBL:PDH64990.1};
GN ORFNames=CNE89_12495 {ECO:0000313|EMBL:PDH64990.1};
OS Sphingomonadaceae bacterium MED-G03.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Sphingomonadales;
OC Sphingomonadaceae.
OX NCBI_TaxID=1986231 {ECO:0000313|EMBL:PDH64990.1, ECO:0000313|Proteomes:UP000219365};
RN [1] {ECO:0000313|EMBL:PDH64990.1, ECO:0000313|Proteomes:UP000219365}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MED-G03 {ECO:0000313|EMBL:PDH64990.1};
RA Haro-Moreno J.M., Lopez-Perez M., De La Torre J., Picazo A., Camacho A.,
RA Rodriguez-Valera F.;
RT "Fine stratification of microbial communities through a metagenomic profile
RT of the photic zone.";
RL Submitted (AUG-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the HIBADH-related family.
CC {ECO:0000256|ARBA:ARBA00009080}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PDH64990.1}.
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DR EMBL; NTKY01000043; PDH64990.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2A5YJS4; -.
DR Proteomes; UP000219365; Unassembled WGS sequence.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR GO; GO:0016054; P:organic acid catabolic process; IEA:UniProt.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR002204; 3-OH-isobutyrate_DH-rel_CS.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR006115; 6PGDH_NADP-bd.
DR InterPro; IPR029154; HIBADH-like_NADP-bd.
DR InterPro; IPR015815; HIBADH-related.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43060; 3-HYDROXYISOBUTYRATE DEHYDROGENASE-LIKE 1, MITOCHONDRIAL-RELATED; 1.
DR PANTHER; PTHR43060:SF15; 3-HYDROXYISOBUTYRATE DEHYDROGENASE-LIKE 1, MITOCHONDRIAL-RELATED; 1.
DR Pfam; PF14833; NAD_binding_11; 1.
DR Pfam; PF03446; NAD_binding_2; 1.
DR PIRSF; PIRSF000103; HIBADH; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00895; 3_HYDROXYISOBUT_DH; 1.
PE 3: Inferred from homology;
KW NAD {ECO:0000256|ARBA:ARBA00023027}.
FT DOMAIN 3..163
FT /note="6-phosphogluconate dehydrogenase NADP-binding"
FT /evidence="ECO:0000259|Pfam:PF03446"
FT DOMAIN 166..285
FT /note="3-hydroxyisobutyrate dehydrogenase-like NAD-binding"
FT /evidence="ECO:0000259|Pfam:PF14833"
FT ACT_SITE 172
FT /evidence="ECO:0000256|PIRSR:PIRSR000103-1"
SQ SEQUENCE 289 AA; 30267 MW; 9C091B3B3DCFAB60 CRC64;
MARIAFIGLG TMGGPMAGHL AKAGHELTVY NRSIGKAKSW AEAYGGQVAI SAAKAAEDAE
IVISCVGTDD DLAQVALGRE GAFRSMQPGG LFIDHTTVSA RIARQLFVEG ESRGIHSVDA
PVTGGHSGAQ DGRLSIMCGG SEPAVAAARI VMQAYAARIV HVGGAGAGQT AKMVNQICIA
GVIQGLSEAL RFAQAAELDL DAVFEAISGG AAQSWQMDHY WGTMARDEFD FGFAVDWMRK
DLGLALEEAR ANGATLPVTA MIDQFYADVQ AMGGHRQDTS ALVRRLTRA
//
