ID A0A2A7MFQ5_9CLOT Unreviewed; 1432 AA.
AC A0A2A7MFQ5;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE SubName: Full=2-hydroxyglutaryl-CoA dehydratase {ECO:0000313|EMBL:PEG30672.1};
GN ORFNames=CQ394_02815 {ECO:0000313|EMBL:PEG30672.1};
OS Clostridium neonatale.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=137838 {ECO:0000313|EMBL:PEG30672.1, ECO:0000313|Proteomes:UP000220840};
RN [1] {ECO:0000313|EMBL:PEG30672.1, ECO:0000313|Proteomes:UP000220840}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LCDC99A005 {ECO:0000313|EMBL:PEG30672.1,
RC ECO:0000313|Proteomes:UP000220840};
RA Bernard K., Burdz T., Wiebe D., Balcewich B., Alfa M., Bernier A.-M.;
RT "Effective Description of Clostridium neonatale sp. nov. linked to
RT necrotizing enterocolitis in neonates and a clarification of species
RT assignable to the genus Clostridium (Prazmowski 1880) emend. Lawson and
RT Rainey 2016.";
RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PEG30672.1}.
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DR EMBL; PDCJ01000001; PEG30672.1; -; Genomic_DNA.
DR RefSeq; WP_058294842.1; NZ_PDCJ01000001.1.
DR STRING; 137838.GCA_001458595_02021; -.
DR OrthoDB; 9802715at2; -.
DR Proteomes; UP000220840; Unassembled WGS sequence.
DR GO; GO:0051536; F:iron-sulfur cluster binding; IEA:UniProtKB-KW.
DR Gene3D; 3.30.420.40; -; 4.
DR InterPro; IPR002731; ATPase_BadF.
DR InterPro; IPR043129; ATPase_NBD.
DR InterPro; IPR018709; CoA_activase_DUF2229.
DR InterPro; IPR008275; CoA_E_activase_dom.
DR NCBIfam; TIGR00241; CoA_E_activ; 1.
DR PANTHER; PTHR32329:SF4; ACTIVATOR OF 2-HYDROXYACYL-COA DEHYDRATASE-RELATED; 1.
DR PANTHER; PTHR32329; BIFUNCTIONAL PROTEIN [INCLUDES 2-HYDROXYACYL-COA DEHYDRATASE (N-TER) AND ITS ACTIVATOR DOMAIN (C_TERM)-RELATED; 1.
DR Pfam; PF01869; BcrAD_BadFG; 2.
DR Pfam; PF09989; DUF2229; 1.
DR SUPFAM; SSF53067; Actin-like ATPase domain; 2.
PE 4: Predicted;
KW Iron {ECO:0000256|ARBA:ARBA00023014};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00023014};
KW Reference proteome {ECO:0000313|Proteomes:UP000220840}.
FT DOMAIN 6..256
FT /note="ATPase BadF/BadG/BcrA/BcrD type"
FT /evidence="ECO:0000259|Pfam:PF01869"
FT DOMAIN 321..574
FT /note="ATPase BadF/BadG/BcrA/BcrD type"
FT /evidence="ECO:0000259|Pfam:PF01869"
FT DOMAIN 671..890
FT /note="DUF2229"
FT /evidence="ECO:0000259|Pfam:PF09989"
SQ SEQUENCE 1432 AA; 160218 MW; B8C782C74010C197 CRC64;
MNIYKIGLDI GSTTVKLVVL NEENIVEYSQ YKRHNSDIRS TIIELVNECY DKIGNVECKI
SITGSGGLSV SKWTNIDFVQ EVIACSKTVE TFIPETDVVI ELGGEDAKIT YFKNGIEQRM
NGSCAGGTGA FIDQMASLLN TDAAGLNEYA KSYNVIYPIA SRCGVFAKTD VQPLINEGAN
KEDIAVSILQ AVVNQTIGGL ACGKPIRGKV AFLGGPLFFL SELRERFIET LKLKDDEIII
PDDSQLFVAM GAALLAVDNM KTTLKNVVNK VNNITNLKED NENKLEALFE SEKDYEDFKN
RHNKSVVKRC PMESYKGQAY LGIDAGSTTT KVTLINEAGE LLYSYYGSNE GNPLKKVVEI
LQDLYSKLPS SIKIVNSAVT GYGESLIKAA LHVDIGEIET IAHYKAADYF LPGVDFILDI
GGQDMKCLKI KNGAIDSIML NEACSSGCGS FIESFSKSLG MPIDKFAKEA LLSKAPVDLG
SRCTVFMNSR VKQVQKEGAQ ICDISAGLSY SVIKNALFKV IKLRDENDIG EKVIVQGGTF
YNDAVLRAFE IISGREAVRP DIAGLMGAFG CSLIAKERYL EGRTTSLLPK EKIDQFKMTS
SFRRCGMCGN NCLLTVNKFS TDEEFISGNR CERGLGIEKK KEEKEINLYD YKYKRTFGYK
PLKEEEAKRG TIGIPRVLNM YENYPFWFTL LTKLGFRVIL SNPSSKKIYE LGIETIPSES
ACYPAKLAHG HIMNLIQKNI KTIFYPCISY EKKEFEDSQN NYNCPMVTSY PEVIKNNMDE
LKINEIKYIA PFFSLDNENV LAKRIVEEFK EFDVTLSEAK EAVKSAVLER EAYKRDIQKK
GEETLEYLRK NNKKGIVLCG RPYHIDPEIN HGIPDMINSF GMAVLTEDSI SHIECLNEKL
RVVDQWVYHS RLYRAATLIA GEPCLEIIQL NSFGCGLDAV TTEQVSEIIS SKGKIYTVLK
IDEGNNLGAA RIRIRSLKAA IEERERKNYK PIEEKISYKN PVFTKEMRKD YTILAPQMSP
IHFNLIEVAG KAAGYNIEVL PSNDAEAIEE GLKYVNNDAC YPSIIVVGQM ISALKSGKYD
LNKTALIMSQ TGGGCRATNY IGFLKAALRH AGFENVPIIS LNVAGLETQP GFNITPKLIK
KALMALVYGD LFMTVLYRTR PYEKVKDSAN ELYNKWNERA KANIVNGSKT EFNKNIKEII
KEFDELPLFN INKPRVGIVG EILVKFHPTA NNDIVKILED EGAEAVVPDL LDFFFYSAYD
NKFKAEYLGK SKVAKTVSGL AIFYMETYRK VMKKELENSN RFSRPKHIKE LANMASPILS
LGHQTGEGWF LTAEMIELIK SGTKNIVCLQ PFACLPNHVT GKGMMKVLKE KYPESNIVAI
DYDPGASHVN QLNRIKLMLS VAVKNLQNNE INFKESEESQ EEIQYHNKIS LT
//
