ID A0A2A7MFZ8_9CLOT Unreviewed; 216 AA.
AC A0A2A7MFZ8;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE SubName: Full=ATP-binding protein {ECO:0000313|EMBL:CAG9709213.1, ECO:0000313|EMBL:PEG30490.1};
DE SubName: Full=tRNA-specific 2-thiouridylase MnmA {ECO:0000313|EMBL:VCT83885.1};
DE EC=2.8.1.- {ECO:0000313|EMBL:VCT83885.1};
GN Name=mnmA_2 {ECO:0000313|EMBL:VCT83885.1};
GN ORFNames=CNEO_44064 {ECO:0000313|EMBL:CAG9709213.1},
GN CNEONATNEC25_01483 {ECO:0000313|EMBL:VCT83885.1}, CQ394_01845
GN {ECO:0000313|EMBL:PEG30490.1};
OS Clostridium neonatale.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=137838 {ECO:0000313|EMBL:PEG30490.1, ECO:0000313|Proteomes:UP000220840};
RN [1] {ECO:0000313|EMBL:PEG30490.1, ECO:0000313|Proteomes:UP000220840}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LCDC99A005 {ECO:0000313|EMBL:PEG30490.1,
RC ECO:0000313|Proteomes:UP000220840};
RA Bernard K., Burdz T., Wiebe D., Balcewich B., Alfa M., Bernier A.-M.;
RT "Effective Description of Clostridium neonatale sp. nov. linked to
RT necrotizing enterocolitis in neonates and a clarification of species
RT assignable to the genus Clostridium (Prazmowski 1880) emend. Lawson and
RT Rainey 2016.";
RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:VCT83885.1, ECO:0000313|Proteomes:UP000431451}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NEC25 {ECO:0000313|EMBL:VCT83885.1,
RC ECO:0000313|Proteomes:UP000431451};
RG IHU Genomes;
RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:CAG9709213.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CC3_PB {ECO:0000313|EMBL:CAG9709213.1};
RA Mesa V.;
RL Submitted (OCT-2021) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; CAKJVE010000004; CAG9709213.1; -; Genomic_DNA.
DR EMBL; PDCJ01000001; PEG30490.1; -; Genomic_DNA.
DR EMBL; UWJD01000001; VCT83885.1; -; Genomic_DNA.
DR RefSeq; WP_058294664.1; NZ_UWJD01000001.1.
DR STRING; 137838.GCA_001458595_01818; -.
DR GeneID; 68876832; -.
DR OrthoDB; 3572539at2; -.
DR Proteomes; UP000220840; Unassembled WGS sequence.
DR Proteomes; UP000431451; Unassembled WGS sequence.
DR Proteomes; UP000789738; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR CDD; cd01994; Alpha_ANH_like_IV; 1.
DR Gene3D; 3.40.50.620; HUPs; 1.
DR Gene3D; 3.90.1490.10; putative n-type atp pyrophosphatase, domain 2; 1.
DR InterPro; IPR002761; Diphthami_syn_dom.
DR InterPro; IPR030662; DPH6/MJ0570.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR NCBIfam; TIGR00290; MJ0570_dom; 1.
DR PANTHER; PTHR12196:SF2; DIPHTHINE--AMMONIA LIGASE; 1.
DR PANTHER; PTHR12196; DOMAIN OF UNKNOWN FUNCTION 71 DUF71 -CONTAINING PROTEIN; 1.
DR Pfam; PF01902; Diphthami_syn_2; 1.
DR PIRSF; PIRSF039123; Diphthamide_synthase; 1.
DR SUPFAM; SSF52402; Adenine nucleotide alpha hydrolases-like; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000313|EMBL:PEG30490.1};
KW Nucleotide-binding {ECO:0000313|EMBL:PEG30490.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000220840};
KW Transferase {ECO:0000313|EMBL:VCT83885.1}.
FT DOMAIN 5..215
FT /note="Diphthamide synthase"
FT /evidence="ECO:0000259|Pfam:PF01902"
SQ SEQUENCE 216 AA; 24823 MW; 98D5BA4BD7263A95 CRC64;
MENKKVVISF SGGKDSTLSL YRMIKQGYEI IGLLVTFDEN NNSCFHKIPE KIFEYISKSL
QIDLYKIECS NEKIYEKEFE KTLKKAKNNG ADICVFGDID IEHHKKWGID RCKNAEVEAY
FPLWQEDREK LTHEFIDSGF NAIIKKVDLK KLSENYLGKT LTNDLVDDIK NLGCDPCGEN
GEYHTLVIDG PIFSKKIEMN IIGKEIVGEY GYLIVS
//
