ID A0A2A7MLB6_9CLOT Unreviewed; 497 AA.
AC A0A2A7MLB6;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE RecName: Full=Galactose-1-phosphate uridylyltransferase {ECO:0000256|HAMAP-Rule:MF_00571};
DE Short=Gal-1-P uridylyltransferase {ECO:0000256|HAMAP-Rule:MF_00571};
DE EC=2.7.7.12 {ECO:0000256|HAMAP-Rule:MF_00571};
DE AltName: Full=UDP-glucose--hexose-1-phosphate uridylyltransferase {ECO:0000256|HAMAP-Rule:MF_00571};
GN Name=galT {ECO:0000256|HAMAP-Rule:MF_00571,
GN ECO:0000313|EMBL:PEG32307.1};
GN ORFNames=CQ394_11620 {ECO:0000313|EMBL:PEG32307.1};
OS Clostridium neonatale.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=137838 {ECO:0000313|EMBL:PEG32307.1, ECO:0000313|Proteomes:UP000220840};
RN [1] {ECO:0000313|EMBL:PEG32307.1, ECO:0000313|Proteomes:UP000220840}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LCDC99A005 {ECO:0000313|EMBL:PEG32307.1,
RC ECO:0000313|Proteomes:UP000220840};
RA Bernard K., Burdz T., Wiebe D., Balcewich B., Alfa M., Bernier A.-M.;
RT "Effective Description of Clostridium neonatale sp. nov. linked to
RT necrotizing enterocolitis in neonates and a clarification of species
RT assignable to the genus Clostridium (Prazmowski 1880) emend. Lawson and
RT Rainey 2016.";
RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=alpha-D-galactose 1-phosphate + UDP-alpha-D-glucose = alpha-D-
CC glucose 1-phosphate + UDP-alpha-D-galactose; Xref=Rhea:RHEA:13989,
CC ChEBI:CHEBI:58336, ChEBI:CHEBI:58601, ChEBI:CHEBI:58885,
CC ChEBI:CHEBI:66914; EC=2.7.7.12;
CC Evidence={ECO:0000256|ARBA:ARBA00001107, ECO:0000256|HAMAP-
CC Rule:MF_00571};
CC -!- PATHWAY: Carbohydrate metabolism; galactose metabolism.
CC {ECO:0000256|ARBA:ARBA00004947, ECO:0000256|HAMAP-Rule:MF_00571}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC ECO:0000256|HAMAP-Rule:MF_00571}.
CC -!- SIMILARITY: Belongs to the galactose-1-phosphate uridylyltransferase
CC type 2 family. {ECO:0000256|ARBA:ARBA00008706, ECO:0000256|HAMAP-
CC Rule:MF_00571}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PEG32307.1}.
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DR EMBL; PDCJ01000001; PEG32307.1; -; Genomic_DNA.
DR RefSeq; WP_058296453.1; NZ_PDCJ01000001.1.
DR AlphaFoldDB; A0A2A7MLB6; -.
DR STRING; 137838.GCA_001458595_03815; -.
DR OrthoDB; 2293at2; -.
DR UniPathway; UPA00214; -.
DR Proteomes; UP000220840; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008108; F:UDP-glucose:hexose-1-phosphate uridylyltransferase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006012; P:galactose metabolic process; IEA:UniProtKB-UniRule.
DR HAMAP; MF_00571; GalP_UDP_trans; 1.
DR InterPro; IPR000766; GalP_uridyl_Trfase_II.
DR InterPro; IPR023425; GalP_uridyl_Trfase_II_CS.
DR InterPro; IPR005850; GalP_Utransf_C.
DR InterPro; IPR005849; GalP_Utransf_N.
DR NCBIfam; TIGR01239; galT_2; 1.
DR PANTHER; PTHR39191:SF1; DUF4922 DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR39191; GALACTOSE-1-PHOSPHATE URIDYLYLTRANSFERASE; 1.
DR Pfam; PF02744; GalP_UDP_tr_C; 1.
DR Pfam; PF01087; GalP_UDP_transf; 1.
DR PIRSF; PIRSF006005; GalT_BS; 1.
DR PROSITE; PS01163; GAL_P_UDP_TRANSF_II; 1.
PE 3: Inferred from homology;
KW Carbohydrate metabolism {ECO:0000256|ARBA:ARBA00023277, ECO:0000256|HAMAP-
KW Rule:MF_00571};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|HAMAP-Rule:MF_00571};
KW Galactose metabolism {ECO:0000256|ARBA:ARBA00023144, ECO:0000256|HAMAP-
KW Rule:MF_00571};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695, ECO:0000256|HAMAP-
KW Rule:MF_00571}; Reference proteome {ECO:0000313|Proteomes:UP000220840};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|HAMAP-
KW Rule:MF_00571}.
FT DOMAIN 19..229
FT /note="Galactose-1-phosphate uridyl transferase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF01087"
FT DOMAIN 245..427
FT /note="Galactose-1-phosphate uridyl transferase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02744"
SQ SEQUENCE 497 AA; 57320 MW; 7817AF4A4BCF1AB3 CRC64;
MINHEINRLI NFGLQQGLIS EEDKIYTSNM LIGLLKLNEF EIEEINETLD TATPILENIL
NYAVAENMIE NTVTERDLLD TNIMNCLMPR PSEVISKFNN LYTKCPKDAT DYFYKLSIAS
NYIRKDRIDK NIIWKASTEY GDLDITINLS KPEKDPKEIA KAKLFKSTSY PKCLLCKENE
GFYGNMNHPA RQTHRIIPLN LGHEEYFLQY SPYTYYNEHC IIFNGEHIPM KIDRKAFTNL
LNFVDILPHY FAGSNADLPI VGGSILSHDH YQGGRYTFAM ELAPTEKEYK IHGYEDITVG
RVKWPMSVIR ISGNSKDKLI NLAEHILSSW RKYSDASVHI LHETNGEPHN TITPIARKRD
GRYEFDLVLR NNRTSNEYPL GIFHPHNEVH HIKKENIGLI EVMGLAVLPA RLKDELGLLK
ECLIKKVEDI SENEAIAKHS DWYKYLLNKY NHIDENNAYG ILQKEVGIKF SEVLNHAGVF
KRDTVGMSAF DKFVNSL
//
