ID A0A2A7MMD3_9CLOT Unreviewed; 654 AA.
AC A0A2A7MMD3;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Cell wall hydrolase {ECO:0000313|EMBL:PEG32836.1};
GN ORFNames=CQ394_12790 {ECO:0000313|EMBL:PEG32836.1};
OS Clostridium neonatale.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=137838 {ECO:0000313|EMBL:PEG32836.1, ECO:0000313|Proteomes:UP000220840};
RN [1] {ECO:0000313|EMBL:PEG32836.1, ECO:0000313|Proteomes:UP000220840}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LCDC99A005 {ECO:0000313|EMBL:PEG32836.1,
RC ECO:0000313|Proteomes:UP000220840};
RA Bernard K., Burdz T., Wiebe D., Balcewich B., Alfa M., Bernier A.-M.;
RT "Effective Description of Clostridium neonatale sp. nov. linked to
RT necrotizing enterocolitis in neonates and a clarification of species
RT assignable to the genus Clostridium (Prazmowski 1880) emend. Lawson and
RT Rainey 2016.";
RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PEG32836.1}.
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DR EMBL; PDCJ01000001; PEG32836.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2A7MMD3; -.
DR STRING; 137838.GCA_001458595_04048; -.
DR OrthoDB; 9763643at2; -.
DR Proteomes; UP000220840; Unassembled WGS sequence.
DR GO; GO:0004040; F:amidase activity; IEA:InterPro.
DR GO; GO:0008745; F:N-acetylmuramoyl-L-alanine amidase activity; IEA:InterPro.
DR GO; GO:0009253; P:peptidoglycan catabolic process; IEA:InterPro.
DR CDD; cd02696; MurNAc-LAA; 1.
DR Gene3D; 2.10.270.10; Cholin Binding; 2.
DR Gene3D; 3.40.630.40; Zn-dependent exopeptidases; 1.
DR InterPro; IPR018337; Cell_wall/Cho-bd_repeat.
DR InterPro; IPR002901; MGlyc_endo_b_GlcNAc-like_dom.
DR InterPro; IPR002508; MurNAc-LAA_cat.
DR PANTHER; PTHR30404; N-ACETYLMURAMOYL-L-ALANINE AMIDASE; 1.
DR PANTHER; PTHR30404:SF0; N-ACETYLMURAMOYL-L-ALANINE AMIDASE AMIC; 1.
DR Pfam; PF01520; Amidase_3; 1.
DR Pfam; PF01473; Choline_bind_1; 5.
DR Pfam; PF19127; Choline_bind_3; 2.
DR Pfam; PF01832; Glucosaminidase; 1.
DR SMART; SM00646; Ami_3; 1.
DR SUPFAM; SSF69360; Cell wall binding repeat; 2.
DR SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
DR PROSITE; PS51170; CW; 7.
PE 4: Predicted;
KW Hydrolase {ECO:0000313|EMBL:PEG32836.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000220840};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT REPEAT 247..266
FT /note="Cell wall-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00591"
FT REPEAT 267..286
FT /note="Cell wall-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00591"
FT REPEAT 287..306
FT /note="Cell wall-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00591"
FT REPEAT 307..326
FT /note="Cell wall-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00591"
FT REPEAT 347..366
FT /note="Cell wall-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00591"
FT REPEAT 367..386
FT /note="Cell wall-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00591"
FT REPEAT 387..406
FT /note="Cell wall-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00591"
FT DOMAIN 527..651
FT /note="MurNAc-LAA"
FT /evidence="ECO:0000259|SMART:SM00646"
FT REGION 190..221
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 200..221
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 654 AA; 71174 MW; 565C1AFD801040F8 CRC64;
MVLALIPMNK VDAATLTDIK IISETNVTVK QAEKWAKSKN ASEEFIELAQ IYFDYAEEHG
GVNPAVAYVQ SAKETGYGNF GGVLDSTYHN PCGLKTSSGG DDYNPDAHQR FDTWEQGVKA
HLDHLALYAG AKGYPRSDTE DPRHFATIKG KATTVNSLGG NWAPSTTYGE EVNKLYRDLL
SYSGATLTED EEIKDNSSNS DKNDNSSNNG SETTNNPPNF NVVIPEAVQA TEPVAKPVNE
PSNISSTIGW KKENGTWYYY RSNGSKATGW IKPGNDWYYL YSSGAMATGW SNIGGKWYYL
KPSGEMQIGW LKDGSTWYYL EGNGAMSTGM KLINGKKYFL DTSGAMRTSW FKISGNWYYF
SGNGDMVTGW IRPDGNWYYI HDNGTMATGW AKVKDQWYYL NSNGAMATGW IVYNSDYYYL
TSSGALAVST VIDGWQIGSD GKRGDKVSSG GPSSSKVIVV DPGHNFGGDD GAYATHNGIT
YAERDLNMET SLKLKTKLEE KGYTVLLTRN PSDRETLGVT QSLTNRVNLA NNFGADFFVS
IHHNSAGAAS ANGVEVYYSS NGQDASFGGA TSSSKVSTSR TLATSIVNSI SNQTGAYNRG
AKDNNFFVCR NTKMPSVLVE VGFITNPTEA ANCANPIYQD KVATAIANAI ASNI
//
