ID A0A2A7MMV3_9CLOT Unreviewed; 963 AA.
AC A0A2A7MMV3;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=DNA topoisomerase (ATP-hydrolyzing) {ECO:0000256|ARBA:ARBA00012895};
DE EC=5.6.2.2 {ECO:0000256|ARBA:ARBA00012895};
GN ORFNames=CQ394_11330 {ECO:0000313|EMBL:PEG32823.1};
OS Clostridium neonatale.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=137838 {ECO:0000313|EMBL:PEG32823.1, ECO:0000313|Proteomes:UP000220840};
RN [1] {ECO:0000313|EMBL:PEG32823.1, ECO:0000313|Proteomes:UP000220840}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LCDC99A005 {ECO:0000313|EMBL:PEG32823.1,
RC ECO:0000313|Proteomes:UP000220840};
RA Bernard K., Burdz T., Wiebe D., Balcewich B., Alfa M., Bernier A.-M.;
RT "Effective Description of Clostridium neonatale sp. nov. linked to
RT necrotizing enterocolitis in neonates and a clarification of species
RT assignable to the genus Clostridium (Prazmowski 1880) emend. Lawson and
RT Rainey 2016.";
RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP-dependent breakage, passage and rejoining of double-
CC stranded DNA.; EC=5.6.2.2; Evidence={ECO:0000256|ARBA:ARBA00000185};
CC -!- SIMILARITY: Belongs to the type II topoisomerase GyrA/ParC subunit
CC family. {ECO:0000256|ARBA:ARBA00008263}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PEG32823.1}.
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DR EMBL; PDCJ01000001; PEG32823.1; -; Genomic_DNA.
DR RefSeq; WP_058296955.1; NZ_PDCJ01000001.1.
DR AlphaFoldDB; A0A2A7MMV3; -.
DR STRING; 137838.GCA_001458595_03755; -.
DR OrthoDB; 9806486at2; -.
DR Proteomes; UP000220840; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003918; F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity; IEA:UniProtKB-EC.
DR GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR CDD; cd00187; TOP4c; 1.
DR Gene3D; 3.30.1360.40; -; 1.
DR Gene3D; 2.120.10.90; DNA gyrase/topoisomerase IV, subunit A, C-terminal; 1.
DR Gene3D; 3.90.199.10; Topoisomerase II, domain 5; 1.
DR Gene3D; 1.10.268.10; Topoisomerase, domain 3; 1.
DR InterPro; IPR006691; GyrA/parC_rep.
DR InterPro; IPR035516; Gyrase/topoIV_suA_C.
DR InterPro; IPR013760; Topo_IIA-like_dom_sf.
DR InterPro; IPR013758; Topo_IIA_A/C_ab.
DR InterPro; IPR013757; Topo_IIA_A_a_sf.
DR InterPro; IPR002205; Topo_IIA_dom_A.
DR PANTHER; PTHR43493:SF5; DNA GYRASE SUBUNIT A, CHLOROPLASTIC_MITOCHONDRIAL; 1.
DR PANTHER; PTHR43493; DNA GYRASE/TOPOISOMERASE SUBUNIT A; 1.
DR Pfam; PF03989; DNA_gyraseA_C; 7.
DR Pfam; PF00521; DNA_topoisoIV; 1.
DR SMART; SM00434; TOP4c; 1.
DR SUPFAM; SSF101904; GyrA/ParC C-terminal domain-like; 2.
DR SUPFAM; SSF56719; Type II DNA topoisomerase; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000313|EMBL:PEG32823.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000220840};
KW Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT DOMAIN 18..478
FT /note="DNA topoisomerase type IIA"
FT /evidence="ECO:0000259|SMART:SM00434"
FT COILED 450..491
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 963 AA; 109093 MW; 93417BD368B03FE8 CRC64;
MAKKTDTLIP KDKNIVGVPL EDAMPENYLP YAIEVAKDRA LPDVRDGLKP VHRRILYGAY
MLKAFPDRPY YKSARIVGDI LGKYHPHGDT SVYEAMVILA QDFSTRKPLI EGHGNWGSID
GDGAAAMRYT EARLSPIALE MLRDIDKETV EMIPNYSDSE MEPKVLPSRY PNLLVNGAFG
IAVGLATNIP PHNLTEVTNG VLAYIDNNEI STKELMEYIK GPDLPTGGIL IGEKSLLSAY
ETGEGKVAYR AKTSIEKLEN GRLGIVITEF PYRRNKAKLL QTISEMTGDK KHSKVLESIT
DIRDESDRNG IRAVIEFKKS TDETTADKVL KYLFKKTDLQ CNISFNMVAL ANGKPETMGL
KAIIKYYVEH QKEIVTKRTI KELEAAKKRY HIVEGFIKAI NILDEVIATI RSSKSKKDAS
DNLISKYGFT EIQAQAILEL MLYRLTGLEI TAFEKEYAQL EQLIKKLEKI LASEKELLKV
IKKELKEVTD KYGDERRTQI IHDDTVSKID LEELIVIEDV MVTVSNDGFI KRLPLKNYNR
SNSNPEDIEY REGDSLKYLI SANTKDTLMI FTNKGFMYQT KGINIPEMKW KEKGERLDRI
IKTLNLEEEK IVSIISLDNL NPDKAFKFMT SRGGIKITSL EKFKTSYTKL QALKLKEYDE
LISVNLKELK DEEKNLKIKT KLGLEFTLEV PEIEEAGRNI LPVQLFNLSD HDEVINVEEV
EGIDYFELNI GINEKGKLKA YKTVKEDLLK VKTNSLSELM IFTNIGNVYK IPVFLMKKLM
EEEVSVETFV GALDKKEKVV TLMSVNSYEE DTVVYLFSKK GMVKKTLLKE FEGDVLKQAC
YKFKFEDDEV VAADINKIKL GYLVMITKKG MAIRFPVENV NPMGKIASGV TGISLREDDE
VIFGKFTSDY VEAGGNTIVL TTNSKQKENI NIKDIKLQNR AGRGNNMIVL VLGDEIKNIN
IDN
//
