ID A0A2A7MS53_MYCAG Unreviewed; 1160 AA.
AC A0A2A7MS53;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=ATPase {ECO:0000313|EMBL:GFG54698.1};
DE SubName: Full=Nuclease {ECO:0000313|EMBL:PEG34504.1};
GN ORFNames=CQY20_25130 {ECO:0000313|EMBL:PEG34504.1}, MAGR_61390
GN {ECO:0000313|EMBL:GFG54698.1};
OS Mycolicibacterium agri (Mycobacterium agri).
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycolicibacterium.
OX NCBI_TaxID=36811 {ECO:0000313|EMBL:PEG34504.1, ECO:0000313|Proteomes:UP000220914};
RN [1] {ECO:0000313|EMBL:PEG34504.1, ECO:0000313|Proteomes:UP000220914}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CCUG37673 {ECO:0000313|EMBL:PEG34504.1,
RC ECO:0000313|Proteomes:UP000220914};
RA Tortoli E., Trovato A., Cirillo D.M.;
RT "The new phylogeny of genus Mycobacterium.";
RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:GFG54698.1, ECO:0000313|Proteomes:UP000465302}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JCM 6377 {ECO:0000313|EMBL:GFG54698.1,
RC ECO:0000313|Proteomes:UP000465302};
RX PubMed=31287781;
RA Matsumoto Y., Kinjo T., Motooka D., Nabeya D., Jung N., Uechi K., Horii T.,
RA Iida T., Fujita J., Nakamura S.;
RT "Comprehensive subspecies identification of 175 nontuberculous mycobacteria
RT species based on 7547 genomic profiles.";
RL Emerg. Microbes Infect. 8:1043-1053(2019).
RN [3] {ECO:0000313|EMBL:GFG54698.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=JCM 6377 {ECO:0000313|EMBL:GFG54698.1};
RA Matsumoto Y., Motooka D., Nakamura S.;
RL Submitted (FEB-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PEG34504.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BLKS01000002; GFG54698.1; -; Genomic_DNA.
DR EMBL; PDCP01000062; PEG34504.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2A7MS53; -.
DR OrthoDB; 9757917at2; -.
DR Proteomes; UP000220914; Unassembled WGS sequence.
DR Proteomes; UP000465302; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR CDD; cd17934; DEXXQc_Upf1-like; 1.
DR CDD; cd18808; SF1_C_Upf1; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR041679; DNA2/NAM7-like_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR019993; RecB_nuclease_TM0106_put.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR047187; SF1_C_Upf1.
DR InterPro; IPR038720; YprB_RNase_H-like_dom.
DR NCBIfam; TIGR03491; TM0106 family RecB-like putative nuclease; 1.
DR PANTHER; PTHR43788; DNA2/NAM7 HELICASE FAMILY MEMBER; 1.
DR PANTHER; PTHR43788:SF6; RECBCD ENZYME SUBUNIT RECD; 1.
DR Pfam; PF13087; AAA_12; 1.
DR Pfam; PF13604; AAA_30; 1.
DR Pfam; PF13482; RNase_H_2; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000220914}.
FT DOMAIN 337..524
FT /note="YprB ribonuclease H-like"
FT /evidence="ECO:0000259|Pfam:PF13482"
FT DOMAIN 954..1128
FT /note="DNA2/NAM7 helicase-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13087"
SQ SEQUENCE 1160 AA; 127830 MW; DF5375A03A34EC15 CRC64;
MGAPWDARWS REGPVSVAGR AYSCDVFVVD GRVIYSASDL AAAARCEYAL LRSFDAQLGW
GPPVAVEDEL LTRTAKLGGE HEQRHLDELR DLSPDNVAVI GRPNYTVDGL TAAAEATLQA
VRRRAPVIYQ AAMFDGRFVG FADFLLFDGE RYRLRDTKLA RSVKVEALLQ LAAYAETLTA
TGVPVSDEVE LVLGDTATVG YRVDELVPVY RPRRAALQSL LDRHLAGGTA VRWEDEEVRA
CFRCPECTTQ VREHDDLLLV AGMRASQRAR FIDAGITTMT ELARHEGPVP ELPARATAAL
TAQARLQTAP RIDGKPPVEV IDSQPLNLLP DPDKGDLFFD FEGDPLWTAD GRQWGLEYLW
GVLEVGGAFR PLWAHDRESE RQALVDFLAM VRRRRKRYPN MHIYHYAPYE KTALLRLAGR
YGVGEDEVDD LLRSGVLVDL YPLVRKCIRV GAENYSLKSL EPLYMGAELR TGDVTTAADS
INQYARYCDL RADGRDEEAE IALKQIEEYN RYDCRSTHRL RDWLIKIAIE SAVPPLGPQQ
VGDGVAAEDT DDLARTLLAF AGDGVDGRTP EQTAVALVAA ARGYHRREDK PFWWAHFDRL
NNPVDEWGDT TDVFLVEKAE VVKDWHIPSR ARKNQRWVKL TGALEAGGLA REVFALYDPP
SPSGLSDNPD RRAAGNAEIV GVDDDNVPTE VTICEREPAD GPFTQVPFAL TPRSIVGTKK
LRESIDTFAA HVCDGLPALP DNAVMDILLR RAPRTRSGAP LPHTGNTVTD ITAALLDLDN
SYLAVHGPPG TGKTYTAARI IASLVNNHQW RVGVVAQSHA VVENLFRDLV KAEVDPARIG
KKDTAADNPW QRVDKDNYAA FIATTPGCII GGTAWDFAND DRVDAASLDL LVVEEAGQFC
LANTIAVARA ANNLMLLGDP QQLPQVSQGH HPEPVDASAL GWLVNGHRTL PEQFGYFLDR
SYRMHPAVCE RVSRLAYEGR LGSEESHTAA RRLDGFPPGV RVLTVAHDGN STSSPEEAAR
IVAEIRRLLG TEWTDEDGRR QLGQHDVLVV APYNAQVLLL RDELDTAGLE GVDVGTVDKF
QGRQAPVVFV SMTASSIDDV PRGISFLLNR NRLNVAVSRA KYASIIVRSE TLTDYLPSTP
DRLIELGAFL SLSRCDTPLE
//
