ID A0A2A8HVH1_9SPHN Unreviewed; 656 AA.
AC A0A2A8HVH1;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN ORFNames=B2G71_08370 {ECO:0000313|EMBL:PEQ13101.1};
OS Novosphingobium sp. PC22D.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Sphingomonadales;
OC Sphingomonadaceae; Novosphingobium.
OX NCBI_TaxID=1962403 {ECO:0000313|EMBL:PEQ13101.1, ECO:0000313|Proteomes:UP000220675};
RN [1] {ECO:0000313|EMBL:PEQ13101.1, ECO:0000313|Proteomes:UP000220675}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PC22D {ECO:0000313|EMBL:PEQ13101.1,
RC ECO:0000313|Proteomes:UP000220675};
RA Peterson S.W.;
RL Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PEQ13101.1}.
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DR EMBL; MWMO01000004; PEQ13101.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2A8HVH1; -.
DR OrthoDB; 9806213at2; -.
DR Proteomes; UP000220675; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR003356; DNA_methylase_A-5.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR029464; HSDR_N.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR42998:SF1; TYPE I RESTRICTION ENZYME HINDI METHYLASE SUBUNIT; 1.
DR PANTHER; PTHR42998; TYPE I RESTRICTION ENZYME HINDVIIP M PROTEIN-RELATED; 1.
DR Pfam; PF13588; HSDR_N_2; 1.
DR Pfam; PF02384; N6_Mtase; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000313|EMBL:PEQ13101.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000220675};
KW Transferase {ECO:0000313|EMBL:PEQ13101.1}.
FT DOMAIN 37..156
FT /note="Type I restriction enzyme R protein N-terminal"
FT /evidence="ECO:0000259|Pfam:PF13588"
FT DOMAIN 290..622
FT /note="DNA methylase adenine-specific"
FT /evidence="ECO:0000259|Pfam:PF02384"
SQ SEQUENCE 656 AA; 74415 MW; B483DBB3B626D920 CRC64;
MSTAALRAPS SAQIPVIVQQ GKILDFIDGL TQRNETPEEY VRQEIAKSLV REYDYAKADI
SVEFTLRLGS RKPRADLVIF DEGDDHKQDR ARVIIECKSQ KVKSSDRKEG VGQLHAYMSA
CPNVQYGMWT NGLERYCYRR VEKDGSISFD EIPDIPGKGC SEEDVERPRF DQLKAASSDA
LLFAFRRCHN YIAGNQGLQK PDAFWELLKI IFCKIHDERS SDEVEFYATS KERHNLNGRL
KVKSRIDALY AAVKAEYDTI FRENEEIELE PAVLAYIVSQ LQMYSLLESD IDVKGRAYEE
IVGSNLRGDR GEFFTPRNIC QMAVTMLDPN ERQLIMDPAC GTGGFLITAM NYVIEKIRAA
EIAKWGEIAR AEDAIRARVQ RFAEKFIIGM DLNPSLVKAS KMNMVMNNDG AGGLFQGNSL
KAPATWDDVL RARNVMGTVD LLFTNPPFGS KIPIDDPAIL EKYELGHAWS YDTDTDEWSM
RSDIQKSQPP EILFIERCVR LLKPGTGRCA IVLPDGILGS PGAGYVREWL LRNTRILASI
DLHPDTFQPH VSVQTSVLVL QRKTDEEMAV EKAAGRFNDY QVFMAVANHV GHDKRGNVTY
VRDRSGNEIV EEFEEQTKDY EEGKPIYKRQ LTQRKVVDDN TLQIAQAFRA WLSEQD
//
