ID   A0A2A8HY34_9SPHN        Unreviewed;      1087 AA.
AC   A0A2A8HY34;
DT   20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT   20-DEC-2017, sequence version 1.
DT   27-MAR-2024, entry version 15.
DE   SubName: Full=Multidrug transporter AcrB {ECO:0000313|EMBL:PEQ13797.1};
GN   ORFNames=B2G71_05655 {ECO:0000313|EMBL:PEQ13797.1};
OS   Novosphingobium sp. PC22D.
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Sphingomonadales;
OC   Sphingomonadaceae; Novosphingobium.
OX   NCBI_TaxID=1962403 {ECO:0000313|EMBL:PEQ13797.1, ECO:0000313|Proteomes:UP000220675};
RN   [1] {ECO:0000313|EMBL:PEQ13797.1, ECO:0000313|Proteomes:UP000220675}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PC22D {ECO:0000313|EMBL:PEQ13797.1,
RC   ECO:0000313|Proteomes:UP000220675};
RA   Peterson S.W.;
RL   Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PEQ13797.1}.
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DR   EMBL; MWMO01000002; PEQ13797.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2A8HY34; -.
DR   OrthoDB; 9806532at2; -.
DR   Proteomes; UP000220675; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 3.30.70.1430; Multidrug efflux transporter AcrB pore domain; 2.
DR   Gene3D; 3.30.70.1440; Multidrug efflux transporter AcrB pore domain; 1.
DR   Gene3D; 3.30.70.1320; Multidrug efflux transporter AcrB pore domain like; 1.
DR   Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR   InterPro; IPR027463; AcrB_DN_DC_subdom.
DR   InterPro; IPR001036; Acrflvin-R.
DR   PANTHER; PTHR32063; -; 1.
DR   PANTHER; PTHR32063:SF16; CATION EFFLUX SYSTEM (ACRB_ACRD_ACRF FAMILY); 1.
DR   Pfam; PF00873; ACR_tran; 2.
DR   PRINTS; PR00702; ACRIFLAVINRP.
DR   SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000220675};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        21..38
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        352..371
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        378..398
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        404..424
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        491..511
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        552..572
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        925..944
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        951..971
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        977..1001
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1021..1041
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1053..1075
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   1087 AA;  116613 MW;  AB698B75C83B56B2 CRC64;
     MNLGISGRLT RATIQSPLTP LFLLAAIVVG LISTITIPRE EEPQIKVPMV DIMVQAPGLS
     APDAVELVAK PLETIVRSVD GVEHVYTQAQ DHGVLVTARF LVGSNPEDAA IRINEKIEAN
     KHLIPVGVPF PQVTVRGIND VPIVVLTLAP KPGAAGQWND QALAELAGKL RTEIAKVDDV
     GLTFITGGQT MALRVVPDPA RLALYDVPLS NVIEAVGQAN RAFPAGTVRE DGRTALVVAG
     QSLRDARELS QLTVRSVTGA PVLLSDVARV EREATRDQAR AVRWTRDDKG DWTMAPAVSL
     AIAKRAGANA VVVAEQVVER VHLLQGTLIP QGVEVAVTRN YGETANEKAN ELILHLALAT
     VSIVVLIGFA IGWREAGVTA IVIPTTIMLT MFASNLMGFT INRVSLFALI FSIGILVDDA
     IVMIENIARH WAMQDGAGGD ARSRVDAAIE AVAEVGNPTV IATLTVVAAL LPMLFVSGLM
     GPYMAPIPIN ASAAMIFSFF VAVIIAPWLM IRFARQTLAN GGGGAHADDH GGRLGALYKR
     YASRVIATKR SAWRFLIAVG IATLLACSMF YFKAVTVKLL PFDNKSEVQL LVDLPEGTSL
     ETTARVLQQA ATITRSVPEV VSMEGYAGTS APFNFNGLVR HYFLRSQPEM GDLMVALLPK
     GDRSRSSHEI AVVLREKLEA IPLPAGGSLK VVETPPGPPV LATLLAEIYG PDEATRMNTA
     EQVEKIFRSV PFIVDVDNSF GQPRPTLRLV PDRAKLDHYG LSERQLFDSI GTLLGSRTIG
     YASRNAGTHG SGRDPLPIVL ELDQSQRTWS AALAATPVAV AQGPAGPTLV RLGELVTART
     EPGGQTIFRR DGRGVNMVTA ELAGRYEAPI YGMLAVDEAI EGFDWQAHGL QKPQVILHGQ
     PDDESKPSLL WDGEWEITWV TFRDMGGAFM IALLGIYVLV VGQFRSFTIP LVILTPVPLT
     MVGIVLGHML FRAPFTATSM IGFIALAGII VRNSILLVDF IRHSRSPDKS LRQTLLEAGM
     IRFKPIVLTA AAAMIGAAVI LTDPIFQGLA ISLMFGLASS TLLTVLVIPA IYVVLRDDGR
     ALESHEA
//