ID A0A2A9CTW1_9ACTN Unreviewed; 420 AA.
AC A0A2A9CTW1;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 24-JAN-2024, entry version 17.
DE RecName: Full=isochorismate synthase {ECO:0000256|ARBA:ARBA00012824};
DE EC=5.4.4.2 {ECO:0000256|ARBA:ARBA00012824};
DE AltName: Full=Isochorismate mutase {ECO:0000256|ARBA:ARBA00041564};
GN ORFNames=ATK74_1630 {ECO:0000313|EMBL:PFG17070.1};
OS Propionicimonas paludicola.
OC Bacteria; Actinomycetota; Actinomycetes; Propionibacteriales;
OC Nocardioidaceae; Propionicimonas.
OX NCBI_TaxID=185243 {ECO:0000313|EMBL:PFG17070.1, ECO:0000313|Proteomes:UP000226079};
RN [1] {ECO:0000313|EMBL:PFG17070.1, ECO:0000313|Proteomes:UP000226079}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 15597 {ECO:0000313|EMBL:PFG17070.1,
RC ECO:0000313|Proteomes:UP000226079};
RA Klenk H.-P.;
RT "Sequencing the genomes of 1000 actinobacteria strains.";
RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=chorismate = isochorismate; Xref=Rhea:RHEA:18985,
CC ChEBI:CHEBI:29748, ChEBI:CHEBI:29780; EC=5.4.4.2;
CC Evidence={ECO:0000256|ARBA:ARBA00000799};
CC -!- SIMILARITY: Belongs to the isochorismate synthase family.
CC {ECO:0000256|ARBA:ARBA00005297}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PFG17070.1}.
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DR EMBL; PDJC01000001; PFG17070.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2A9CTW1; -.
DR OrthoDB; 9806579at2; -.
DR Proteomes; UP000226079; Unassembled WGS sequence.
DR GO; GO:0008909; F:isochorismate synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR Gene3D; 3.60.120.10; Anthranilate synthase; 1.
DR InterPro; IPR005801; ADC_synthase.
DR InterPro; IPR015890; Chorismate_C.
DR InterPro; IPR004561; IsoChor_synthase.
DR NCBIfam; TIGR00543; isochor_syn; 1.
DR PANTHER; PTHR42839; ISOCHORISMATE SYNTHASE ENTC; 1.
DR PANTHER; PTHR42839:SF1; ISOCHORISMATE SYNTHASE MENF; 1.
DR Pfam; PF00425; Chorismate_bind; 1.
DR SUPFAM; SSF56322; ADC synthase; 1.
PE 3: Inferred from homology;
KW Isomerase {ECO:0000256|ARBA:ARBA00023235};
KW Reference proteome {ECO:0000313|Proteomes:UP000226079}.
FT DOMAIN 153..405
FT /note="Chorismate-utilising enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00425"
FT REGION 123..143
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 420 AA; 44778 MW; 630C749D1D7A2448 CRC64;
MRHHEPLGKL QARTIEIPDP GELSGYLPRQ DAVAWLRRGE GMIGFGEVAR FQGGSFAEAD
AWWSRLCAEL EHDSELLDLS GTGPLAFGSF PFAASHSRSE ALLIVPRLIL GRRRGRSWLT
LIGGPGDQPE LPPRQSAAAA PSGLRRDVGG LAEADWRGIV EAAVTRITDG ELSKVVLARA
EVHTAERPLD PRWLVGRLSE EYRDCWTFCV AGLIGASPEM LLRREGGLVT SRVLAGTIRR
NGAEELDLKL ARSLARSGKN LAEHELAVAS VAEALAPFTS GMNVPDAPYV LELPNVLHLA
SDVTAVVRPG VSALRLAGEL HPSAAVCGTP TADAAALIAE LEQLDRGRYS GPVGWLDANG
DGEFAIALRC GQIDPDRPET ITVYAGCGIV AESDPAEEWA ETVAKLLPMH QVLGVSSAAS
//
