ID A0A2A9CV76_9ACTN Unreviewed; 441 AA.
AC A0A2A9CV76;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE SubName: Full=DHA3 family macrolide efflux protein-like MFS transporter {ECO:0000313|EMBL:PFG18041.1};
GN ORFNames=ATK74_2621 {ECO:0000313|EMBL:PFG18041.1};
OS Propionicimonas paludicola.
OC Bacteria; Actinomycetota; Actinomycetes; Propionibacteriales;
OC Nocardioidaceae; Propionicimonas.
OX NCBI_TaxID=185243 {ECO:0000313|EMBL:PFG18041.1, ECO:0000313|Proteomes:UP000226079};
RN [1] {ECO:0000313|EMBL:PFG18041.1, ECO:0000313|Proteomes:UP000226079}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 15597 {ECO:0000313|EMBL:PFG18041.1,
RC ECO:0000313|Proteomes:UP000226079};
RA Klenk H.-P.;
RT "Sequencing the genomes of 1000 actinobacteria strains.";
RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|ARBA:ARBA00004429}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004429}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PFG18041.1}.
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DR EMBL; PDJC01000001; PFG18041.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2A9CV76; -.
DR Proteomes; UP000226079; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR CDD; cd06173; MFS_MefA_like; 1.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 1.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR010290; TM_effector.
DR PANTHER; PTHR23513; INTEGRAL MEMBRANE EFFLUX PROTEIN-RELATED; 1.
DR PANTHER; PTHR23513:SF6; MULTIDRUG EFFLUX PUMP TAP; 1.
DR Pfam; PF05977; MFS_3; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
DR PROSITE; PS50850; MFS; 1.
PE 4: Predicted;
KW Antibiotic resistance {ECO:0000256|ARBA:ARBA00023251};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000226079};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 25..45
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 57..80
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 87..109
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 160..181
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 187..206
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 234..253
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 265..284
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 296..315
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 321..344
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 356..380
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 386..406
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 226..441
FT /note="Major facilitator superfamily (MFS) profile"
FT /evidence="ECO:0000259|PROSITE:PS50850"
FT REGION 418..441
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 441 AA; 46762 MW; 42520D87C62924B2 CRC64;
MGSVSSEESV TTVEERPGWR RDITLFLTGQ TVSLFGSMLV QYAVMWYLTL TTKDGTVLAL
STVFGFLPQA IISIFGGVWA DRHNRKLLII GADASIALAT ATLAILMFFG NRELWLIYAA
LAVRSAGAGI QTPAVGALLP QIVPSDRLLS INGINQSIQA GMMLIAPAVA ALLYATLPLY
WILGVDVVTA AIGIGLMTLI PVAKIVRSEA TPTGYFSDLS AGFRYVVTHP LIRWLLGLYA
VVMVLAAAPS FLTPLMVARS FGEEVWKLTV LELSFSIGMM LAGATIGSWG KRFSRIGLIV
GASIGFGFLS IGMGLSSNLW VFYGFMFLTG VAVPVFSTPS MTVLQEVVEP DRQGRVFGFF
GIVSATAMPV GMAVFGPLAN LQSVEFVLIL SGMVTLIVAA IALLLPSGRR AMRAARDHTD
PLSHGHGVSL PTGGAEPAAD A
//
