ID   A0A2A9CWQ2_9ACTN        Unreviewed;      1205 AA.
AC   A0A2A9CWQ2;
DT   20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT   20-DEC-2017, sequence version 1.
DT   24-JAN-2024, entry version 19.
DE   SubName: Full=Multidrug efflux pump subunit AcrB {ECO:0000313|EMBL:PFG18060.1};
GN   ORFNames=ATK74_2640 {ECO:0000313|EMBL:PFG18060.1};
OS   Propionicimonas paludicola.
OC   Bacteria; Actinomycetota; Actinomycetes; Propionibacteriales;
OC   Nocardioidaceae; Propionicimonas.
OX   NCBI_TaxID=185243 {ECO:0000313|EMBL:PFG18060.1, ECO:0000313|Proteomes:UP000226079};
RN   [1] {ECO:0000313|EMBL:PFG18060.1, ECO:0000313|Proteomes:UP000226079}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 15597 {ECO:0000313|EMBL:PFG18060.1,
RC   ECO:0000313|Proteomes:UP000226079};
RA   Klenk H.-P.;
RT   "Sequencing the genomes of 1000 actinobacteria strains.";
RL   Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PFG18060.1}.
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DR   EMBL; PDJC01000001; PFG18060.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2A9CWQ2; -.
DR   OrthoDB; 3306666at2; -.
DR   Proteomes; UP000226079; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 3.30.70.1430; Multidrug efflux transporter AcrB pore domain; 2.
DR   Gene3D; 3.30.70.1440; Multidrug efflux transporter AcrB pore domain; 1.
DR   Gene3D; 3.30.70.1320; Multidrug efflux transporter AcrB pore domain like; 1.
DR   Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 3.
DR   InterPro; IPR027463; AcrB_DN_DC_subdom.
DR   InterPro; IPR001036; Acrflvin-R.
DR   PANTHER; PTHR32063; -; 1.
DR   PANTHER; PTHR32063:SF0; SWARMING MOTILITY PROTEIN SWRC; 1.
DR   Pfam; PF00873; ACR_tran; 2.
DR   PRINTS; PR00702; ACRIFLAVINRP.
DR   SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000226079};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        357..377
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        428..448
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        460..486
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        526..546
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1015..1034
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1041..1060
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1066..1088
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1116..1141
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1147..1171
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REGION          772..801
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          912..932
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        778..801
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1205 AA;  125586 MW;  E11EA1700D3057FD CRC64;
     MVRLSKASLA QRSVVLLLSL LVIALGVYAA GALKQELIPS IDLPRGSVLT IYPGASPEVV
     EAQLSKPIES AVKAVAGVTS VTSKSSSGVS QVSVQWDYGL KPDDMANKIR SAIDSISTGL
     PSSVNPKVIT GSFDDIPIVV LALSSSDDST MLTSKVNQIV VPGLKTIDGV RDVAVGGQET
     REIMISYSPA ELNKKNIDPS LIGQLFAANA TAFPSGTMRT DNANLDVQTG RTYSTAEQIA
     GLQLPTADGP IKLGDVAKVT EQPVETTSIS RVGGKTALTL QVTKEAGANT VSVAKAVGAM
     LPQLEQQLGG NATFTTVFDQ APYIEQSIHD LSVEGGIGLA MAVLVILIFL GSLRPTVITA
     ISIPLSLLIA LIGLWVGGYS LNILTLAALT VAIGRVVDDS IVVIENIKRH QGYGEFGRKS
     ILNAVREVAG AVTSSTLTTV AVFLPIGLVG GQAGEIFRPF ALTVTIALAA SLFVSLTLVP
     VLASWFMRPT AKQQARQQVV EPEAEKDTWL QKAYLPVLNW SLAHRWITAT LAFVLFAGTM
     ALTPLLKTDF LGEQGNESLM ISQKLPAGTS LAETDAAARK IEQLLSSDQA VQTYSTSIGG
     SGSSFLGTQA DTNQANYTVP LKAGYSAKDV VGRIRDQIGA LGSSMGTVEV SVGNSSSSVV
     VYVEGSDQVA LKAANDQVVA MMKDVPDLVN VTSDLSEARD QLSVKVDDRK AADLGMTQLS
     IGQAVSRAVA GQQVGSIAVG DDTLKVYLRV KSPAKSIEQL RDAELPVTQL MSGNAKKDAA
     EKVSDDSKAL QDESKDASDK AYNDQVKALK KARSQAKSAQ ASLASQLSKA KKNLASLQKQ
     LNAALAIPLC SDRPDLTPPA CSPVGTSAAV FQLTQAVSGM SMQVAQLGGA LAQAKSGTSS
     VDKQLDALAT QREKSLEAQD KQQAIQDASK DAQDATAKPV TLSAVAKVEV VQAPATVTRV
     DGVRSATISA SSESADLGAT TAQIQKGLAA LNLPDGISYR IGGVSAQQAE SFAQLGLAML
     VAIAVVYLIM VATFGSLLQP LILLVSIPFA ATGALAFSLI SDTALGLPSM IGLLMLIGIV
     VTNAIVLIDL INQKRKAGLS VDASIAAGAR LRVRPIIMTA LATVFALVPM SLGLTGGGVF
     ISKPLAIVVI GGLVSSTLLT LILVPVLYDL LETWRERRET KRDARRAARL ADAVAAQQDA
     AATEA
//