ID A0A2A9E4H9_9MICO Unreviewed; 328 AA.
AC A0A2A9E4H9;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 24-JAN-2024, entry version 16.
DE RecName: Full=Prephenate dehydratase {ECO:0000256|ARBA:ARBA00021872};
DE EC=4.2.1.51 {ECO:0000256|ARBA:ARBA00013147};
GN ORFNames=ATL42_1641 {ECO:0000313|EMBL:PFG33754.1};
OS Sanguibacter antarcticus.
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Sanguibacteraceae;
OC Sanguibacter.
OX NCBI_TaxID=372484 {ECO:0000313|EMBL:PFG33754.1, ECO:0000313|Proteomes:UP000225548};
RN [1] {ECO:0000313|EMBL:PFG33754.1, ECO:0000313|Proteomes:UP000225548}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 18966 {ECO:0000313|EMBL:PFG33754.1,
RC ECO:0000313|Proteomes:UP000225548};
RA Klenk H.-P.;
RT "Sequencing the genomes of 1000 actinobacteria strains.";
RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H(+) + prephenate = 3-phenylpyruvate + CO2 + H2O;
CC Xref=Rhea:RHEA:21648, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:16526, ChEBI:CHEBI:18005, ChEBI:CHEBI:29934; EC=4.2.1.51;
CC Evidence={ECO:0000256|ARBA:ARBA00000913};
CC -!- PATHWAY: Amino-acid biosynthesis; L-phenylalanine biosynthesis;
CC phenylpyruvate from prephenate: step 1/1.
CC {ECO:0000256|ARBA:ARBA00004741}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PFG33754.1}.
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DR EMBL; PDJG01000001; PFG33754.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2A9E4H9; -.
DR UniPathway; UPA00121; UER00345.
DR Proteomes; UP000225548; Unassembled WGS sequence.
DR GO; GO:0004106; F:chorismate mutase activity; IEA:InterPro.
DR GO; GO:0004664; F:prephenate dehydratase activity; IEA:UniProtKB-EC.
DR GO; GO:0009094; P:L-phenylalanine biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd04905; ACT_CM-PDT; 1.
DR Gene3D; 3.30.70.260; -; 1.
DR Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 2.
DR InterPro; IPR045865; ACT-like_dom_sf.
DR InterPro; IPR002912; ACT_dom.
DR InterPro; IPR008242; Chor_mutase/pphenate_deHydtase.
DR InterPro; IPR001086; Preph_deHydtase.
DR InterPro; IPR018528; Preph_deHydtase_CS.
DR PANTHER; PTHR21022; PREPHENATE DEHYDRATASE P PROTEIN; 1.
DR PANTHER; PTHR21022:SF19; PREPHENATE DEHYDRATASE-RELATED; 1.
DR Pfam; PF01842; ACT; 1.
DR Pfam; PF00800; PDT; 1.
DR PIRSF; PIRSF001500; Chor_mut_pdt_Ppr; 1.
DR SUPFAM; SSF55021; ACT-like; 1.
DR SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
DR PROSITE; PS51671; ACT; 1.
DR PROSITE; PS00857; PREPHENATE_DEHYDR_1; 1.
DR PROSITE; PS51171; PREPHENATE_DEHYDR_3; 1.
PE 4: Predicted;
KW Amino-acid biosynthesis {ECO:0000256|ARBA:ARBA00022605};
KW Aromatic amino acid biosynthesis {ECO:0000256|ARBA:ARBA00023141};
KW Lyase {ECO:0000256|ARBA:ARBA00023239};
KW Phenylalanine biosynthesis {ECO:0000256|ARBA:ARBA00023222};
KW Reference proteome {ECO:0000313|Proteomes:UP000225548}.
FT DOMAIN 9..185
FT /note="Prephenate dehydratase"
FT /evidence="ECO:0000259|PROSITE:PS51171"
FT DOMAIN 206..299
FT /note="ACT"
FT /evidence="ECO:0000259|PROSITE:PS51671"
FT SITE 178
FT /note="Essential for prephenate dehydratase activity"
FT /evidence="ECO:0000256|PIRSR:PIRSR001500-2"
SQ SEQUENCE 328 AA; 33908 MW; 8D065CBB4AA988D7 CRC64;
MTTPDAGSRL AYLGPDGTFT HEAALRWAQA PGAHGIGLEA VRTVAEVYDG VESGAFTHGV
VAIESSVEGY VVPSLDAIVS AENVVAVDET FVEIAFDAFA RPGATEQVTQ VTSHPHGLAQ
CQSFVTGRDL LAVPAASNAA ACRDVQAGQL ALGPRICGEL YGLQTVARGV EDFHGARTRF
LLVTSRDVAA RARPAALDGD AWRTMLAITP HATGPGVLAR ITQAFGALGV NLSSLITRPV
KALEGRYVFI VTIDGAPWDT GVRGVLEGLL AAGDSLKTLG VLPARGELDG TVDAHRVPSG
SVRVDASDAV LDRGLLWSPA VTDGVVGS
//
