ID   A0A2A9EHW1_9MICO        Unreviewed;       504 AA.
AC   A0A2A9EHW1;
DT   20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT   20-DEC-2017, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   RecName: Full=leucine--tRNA ligase {ECO:0000256|ARBA:ARBA00013164};
DE            EC=6.1.1.4 {ECO:0000256|ARBA:ARBA00013164};
GN   ORFNames=ATL41_2627 {ECO:0000313|EMBL:PFG37845.1};
OS   Flavimobilis soli.
OC   Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Jonesiaceae;
OC   Flavimobilis.
OX   NCBI_TaxID=442709 {ECO:0000313|EMBL:PFG37845.1, ECO:0000313|Proteomes:UP000221394};
RN   [1] {ECO:0000313|EMBL:PFG37845.1, ECO:0000313|Proteomes:UP000221394}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 21574 {ECO:0000313|EMBL:PFG37845.1,
RC   ECO:0000313|Proteomes:UP000221394};
RA   Klenk H.-P.;
RT   "Sequencing the genomes of 1000 actinobacteria strains.";
RL   Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the class-I aminoacyl-tRNA synthetase family.
CC       {ECO:0000256|ARBA:ARBA00005594, ECO:0000256|RuleBase:RU363039}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PFG37845.1}.
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DR   EMBL; PDJH01000001; PFG37845.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2A9EHW1; -.
DR   Proteomes; UP000221394; Unassembled WGS sequence.
DR   GO; GO:0002161; F:aminoacyl-tRNA editing activity; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004823; F:leucine-tRNA ligase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006429; P:leucyl-tRNA aminoacylation; IEA:InterPro.
DR   Gene3D; 3.40.50.620; HUPs; 2.
DR   InterPro; IPR001412; aa-tRNA-synth_I_CS.
DR   InterPro; IPR002302; Leu-tRNA-ligase.
DR   InterPro; IPR025709; Leu_tRNA-synth_edit.
DR   InterPro; IPR015413; Methionyl/Leucyl_tRNA_Synth.
DR   InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR   PANTHER; PTHR43740:SF2; LEUCINE--TRNA LIGASE, MITOCHONDRIAL; 1.
DR   PANTHER; PTHR43740; LEUCYL-TRNA SYNTHETASE; 1.
DR   Pfam; PF13603; tRNA-synt_1_2; 1.
DR   Pfam; PF09334; tRNA-synt_1g; 1.
DR   PRINTS; PR00985; TRNASYNTHLEU.
DR   SUPFAM; SSF52374; Nucleotidylyl transferase; 1.
DR   PROSITE; PS00178; AA_TRNA_LIGASE_I; 1.
PE   3: Inferred from homology;
KW   Aminoacyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00023146,
KW   ECO:0000256|RuleBase:RU363039};
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU363039};
KW   Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000256|RuleBase:RU363039};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW   ECO:0000256|RuleBase:RU363039};
KW   Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917,
KW   ECO:0000256|RuleBase:RU363039};
KW   Reference proteome {ECO:0000313|Proteomes:UP000221394}.
FT   DOMAIN          79..183
FT                   /note="Methionyl/Leucyl tRNA synthetase"
FT                   /evidence="ECO:0000259|Pfam:PF09334"
FT   DOMAIN          315..346
FT                   /note="Leucyl-tRNA synthetase editing"
FT                   /evidence="ECO:0000259|Pfam:PF13603"
FT   REGION          1..29
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          355..415
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          473..504
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        478..504
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   504 AA;  56425 MW;  4CE9AE7004095DE8 CRC64;
     MTDKPNVPNQ PAPARSGAPS PEEPRLRYTP QLAEEIELRW QDRWAERGTF WAANPSGPLT
     DGKGRHADPG SPSFFVMDMF PYPSGAGLHV GHPLGYIATD VVGRFRRMCG DNVLHALAFD
     AFGLPAEQYA VQTGQHPRIT TEQNIANMQR QLRRLGLAHD ERRSFATTDS EYVRWTQWIF
     LQIFNSWYDE TAVRPDGGTG KARPIAELEA ELADGTRPTP DGTPWAEMDA VARRRVIDSY
     RLAYVSESPV NWCPGLGTVL ANEEVTADGR SERGNFPVFQ RSLRQWNMRI TAYADRLADD
     LELIDWPDKV KAMQRNWIGR SQGAKVRFDV QGGSEVEVFT TRPDTLSRDL HGRRRAAARG
     REGPAARATA LPGTLPRRSP RRQPADSLER GCSGRRPEVA PNRVSGRVVK TSTSLPPWTS
     NRTLAPCERP IQLRCIALTL SGQSMSSRSS ARRSAYAVMR MFHWRRLRWK TGKLPRSDRP
     SAVTSSFART VPSPGHQFTG DSET
//