GenomeNet

Database: UniProt
Entry: A0A2A9EK73_9MICO
LinkDB: A0A2A9EK73_9MICO
Original site: A0A2A9EK73_9MICO 
ID   A0A2A9EK73_9MICO        Unreviewed;       247 AA.
AC   A0A2A9EK73;
DT   20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT   20-DEC-2017, sequence version 1.
DT   24-JAN-2024, entry version 20.
DE   SubName: Full=DtxR family iron (Metal) dependent repressor {ECO:0000313|EMBL:PFG38931.1};
GN   ORFNames=ATJ97_1423 {ECO:0000313|EMBL:PFG38931.1};
OS   Georgenia soli.
OC   Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Bogoriellaceae;
OC   Georgenia.
OX   NCBI_TaxID=638953 {ECO:0000313|EMBL:PFG38931.1, ECO:0000313|Proteomes:UP000222106};
RN   [1] {ECO:0000313|EMBL:PFG38931.1, ECO:0000313|Proteomes:UP000222106}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 21838 {ECO:0000313|EMBL:PFG38931.1,
RC   ECO:0000313|Proteomes:UP000222106};
RA   Klenk H.-P.;
RT   "Sequencing the genomes of 1000 actinobacteria strains.";
RL   Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC   -!- SIMILARITY: Belongs to the DtxR/MntR family.
CC       {ECO:0000256|ARBA:ARBA00007871}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PFG38931.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; PDJI01000004; PFG38931.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2A9EK73; -.
DR   OrthoDB; 3208141at2; -.
DR   Proteomes; UP000222106; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   GO; GO:0046914; F:transition metal ion binding; IEA:InterPro.
DR   Gene3D; 2.30.30.90; -; 1.
DR   Gene3D; 1.10.60.10; Iron dependent repressor, metal binding and dimerisation domain; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR001367; Fe_dep_repressor.
DR   InterPro; IPR036421; Fe_dep_repressor_sf.
DR   InterPro; IPR038157; FeoA_core_dom.
DR   InterPro; IPR022687; HTH_DTXR.
DR   InterPro; IPR022689; Iron_dep_repressor.
DR   InterPro; IPR008988; Transcriptional_repressor_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR33238; IRON (METAL) DEPENDENT REPRESSOR, DTXR FAMILY; 1.
DR   PANTHER; PTHR33238:SF10; IRON-DEPENDENT REPRESSOR IDER; 1.
DR   Pfam; PF02742; Fe_dep_repr_C; 1.
DR   Pfam; PF01325; Fe_dep_repress; 1.
DR   SMART; SM00529; HTH_DTXR; 1.
DR   SUPFAM; SSF50037; C-terminal domain of transcriptional repressors; 1.
DR   SUPFAM; SSF47979; Iron-dependent repressor protein, dimerization domain; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS50944; HTH_DTXR; 1.
PE   3: Inferred from homology;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Iron {ECO:0000256|ARBA:ARBA00023004};
KW   Reference proteome {ECO:0000313|Proteomes:UP000222106};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT   DOMAIN          1..65
FT                   /note="HTH dtxR-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50944"
SQ   SEQUENCE   247 AA;  27420 MW;  621762FBB2BD6E51 CRC64;
     MSDLIDTTEM YLKTVYELEE EGVVPLRARI AERLGHSGPT VSQTVARMER DGLLVLTGNR
     QLELTDEGRE KATKVMRKHR LAERLLVDVV GLDWPHVHEE ACRWEHVMSE RVERRLLDLL
     DHPHVDPYGN PIPGLADLDR SIVPTPPQPA VRSLSDVVAE LQPAGAPSAA AGGAEADHYV
     VVLERIGEPL QVDVDLLARM AEAGLRPGRR LELRIRGGVD LVSLHAPGAE VELDVPEEIT
     RHLFVTR
//
DBGET integrated database retrieval system