ID   A0A2A9EQB5_9MICO        Unreviewed;       405 AA.
AC   A0A2A9EQB5;
DT   20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT   20-DEC-2017, sequence version 1.
DT   24-JAN-2024, entry version 16.
DE   SubName: Full=Glutathione-independent formaldehyde dehydrogenase {ECO:0000313|EMBL:PFG40462.1};
GN   ORFNames=ATJ97_2992 {ECO:0000313|EMBL:PFG40462.1};
OS   Georgenia soli.
OC   Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Bogoriellaceae;
OC   Georgenia.
OX   NCBI_TaxID=638953 {ECO:0000313|EMBL:PFG40462.1, ECO:0000313|Proteomes:UP000222106};
RN   [1] {ECO:0000313|EMBL:PFG40462.1, ECO:0000313|Proteomes:UP000222106}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 21838 {ECO:0000313|EMBL:PFG40462.1,
RC   ECO:0000313|Proteomes:UP000222106};
RA   Klenk H.-P.;
RT   "Sequencing the genomes of 1000 actinobacteria strains.";
RL   Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947,
CC         ECO:0000256|RuleBase:RU361277};
CC   -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC       family. {ECO:0000256|RuleBase:RU361277}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PFG40462.1}.
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DR   EMBL; PDJI01000004; PFG40462.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2A9EQB5; -.
DR   OrthoDB; 241504at2; -.
DR   Proteomes; UP000222106; Unassembled WGS sequence.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   CDD; cd08282; PFDH_like; 1.
DR   Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR013149; ADH-like_C.
DR   InterPro; IPR013154; ADH-like_N.
DR   InterPro; IPR002328; ADH_Zn_CS.
DR   InterPro; IPR011032; GroES-like_sf.
DR   InterPro; IPR014184; HCHO_DH_non_GSH.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   NCBIfam; TIGR02819; fdhA_non_GSH; 1.
DR   PANTHER; PTHR42813:SF3; GLUTATHIONE-INDEPENDENT FORMALDEHYDE DEHYDROGENASE; 1.
DR   PANTHER; PTHR42813; ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE; 1.
DR   Pfam; PF08240; ADH_N; 1.
DR   Pfam; PF00107; ADH_zinc_N; 1.
DR   SUPFAM; SSF50129; GroES-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   PROSITE; PS00059; ADH_ZINC; 1.
PE   3: Inferred from homology;
KW   Metal-binding {ECO:0000256|RuleBase:RU361277};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000222106};
KW   Zinc {ECO:0000256|RuleBase:RU361277}.
FT   DOMAIN          43..152
FT                   /note="Alcohol dehydrogenase-like N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF08240"
FT   DOMAIN          205..271
FT                   /note="Alcohol dehydrogenase-like C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00107"
SQ   SEQUENCE   405 AA;  42554 MW;  927CB6A276BC9F60 CRC64;
     MTNKAVSYAG PGKVEVIDTP YPEFELKDGP GVNPANVGRQ VHHGVILKTV STNICGSDQH
     MVRGRTTAPE GLVLGHEITG EVVEVGRDVE FIKEGDIVSV PFNIACGRCR NCKERKTGIC
     LNVNPDRPGS AYGYVDMGGW VGGQAEYVLV PYADWNLLKF PDKDQAMEKI LDLTMLSDIF
     PTGYHGAYTA GVTTGSTVYI AGAGPVGLAA ATAAQLLGAA VVIVGDLNEE RLAQARSFGC
     ETVDVSKGDP KDQIEQILGV PEVDCGVDAV GFEARGHGKE AQTEHPATVL NSLMGLTAAG
     GALGIPGLYV TGDPGGVDEA AKVGSLSISL GTGWAKSLSF TTGQCPVMKY HRGLMMAILH
     DKVQIAKNVN ATPISLDEAP RGYEEFDKGA AKKYVLDPHG MVPSS
//