ID A0A2A9F1H2_9MICO Unreviewed; 1591 AA.
AC A0A2A9F1H2;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=ATP-dependent helicase HrpA {ECO:0000313|EMBL:PFG44853.1};
GN ORFNames=ATJ88_3590 {ECO:0000313|EMBL:PFG44853.1};
OS Isoptericola jiangsuensis.
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales;
OC Promicromonosporaceae; Isoptericola.
OX NCBI_TaxID=548579 {ECO:0000313|EMBL:PFG44853.1, ECO:0000313|Proteomes:UP000224130};
RN [1] {ECO:0000313|EMBL:PFG44853.1, ECO:0000313|Proteomes:UP000224130}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 21863 {ECO:0000313|EMBL:PFG44853.1,
RC ECO:0000313|Proteomes:UP000224130};
RA Klenk H.-P.;
RT "Sequencing the genomes of 1000 actinobacteria strains.";
RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PFG44853.1}.
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DR EMBL; PDJJ01000001; PFG44853.1; -; Genomic_DNA.
DR OrthoDB; 9805617at2; -.
DR Proteomes; UP000224130; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:InterPro.
DR CDD; cd18791; SF2_C_RHA; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR048333; HA2_WH.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR024590; HrpA_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR010222; RNA_helicase_HrpA.
DR NCBIfam; TIGR01967; DEAH_box_HrpA; 1.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR PANTHER; PTHR18934:SF83; PRE-MRNA-SPLICING FACTOR ATP-DEPENDENT RNA HELICASE DHX16; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF11898; DUF3418; 1.
DR Pfam; PF21010; HA2_C; 1.
DR Pfam; PF04408; HA2_N; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000313|EMBL:PFG44853.1};
KW Hydrolase {ECO:0000313|EMBL:PFG44853.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT DOMAIN 101..264
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 319..495
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 1..69
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 681..741
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1146..1179
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1217..1269
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 15..29
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 706..720
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1591 AA; 171812 MW; 2F41FD0179B6A9B9 CRC64;
MSTDPSPAVP SRTGDDASAR RREDGARPAA GAGQEDGRPA GRGDGRRRRG RRQGQSGRRG
GPARVSREQL DRAAAIRAAV EVPPITYPEQ LPVSARRAEI ADAIRDHQVV VVAGETGSGK
TTQLPKILLD LGRGRAGQIG HTQPRRIAAR SVAERIAEEL GGELGGVVGY QVRFTDTSSE
DTLVKVMTDG ILLAQIQRDP DLLAYDTIVI DEAHERSLNI DFLLGYLSRL LPRRPDLKLV
ITSATIDSAR FAAHFSPSHL AEIGGAPQAV VDVLPDAAPV VEVTGRTYPV EIRYRPLTPD
PDPAAPAKKK GEEKDLVIGI VEACDELMRV GPGDILVFLS GEREIHDAAD ALEGHLKERV
RDVKHPQHVE ILPLYSRLSA AEQHRVFQSH PGRRIVLSTN VAETSLTVPG IHYVVDPGTA
RISRYSKATK VQRLPIEPVS QASANQRSGR SGRVADGVAI RLYSAEDFAS RPEFTEPEIL
RTSLASVLLQ MISVGVVTTP DDVAKFPFVE PPDTRAVRDG VQLLTELGAL GRRHGRDGTA
SNDVHLTDIG RTLARLPMDP RLARMVIEGA RLGVAHEVAI IAAALSIQDP RERPTESREQ
ADQLHRRFTD PTSDFLTYLN LWEYLREQQH SMGSSAFRRL CKAEHVNFLR FREWQDVVAQ
LRSMAKQLDI DISYQPRTRP VVSEGVDAPP RSRAPGGPPL RLDGGASTPS DTTSATQPDG
RRSAPPAGAA TDGGETQDWR RVWDGDTVHR ALLSGMLSQI GMQDTGEIKA SSVAHLRGEA
RARALRQAAK RARNEYLGAR GARFAIFPGS PLSKKPPEWI MAGELVETSR LWARDVARIQ
PEWAEALAGD LAKRTYSDPH WSTKQGAAMA TEKVLLYGVP VVADRPVLYA RVDPEAAREM
FVRHALVEGQ WTTHHRFFAE NRRLLAEAEE LEARSRQRGL VASEDDLFAF YDERVPADVV
SARHFDTWWK QAQRDTPDLL TFTLDQLVDA DAVDTAAFPE TWTQGEVTLP LTYQFSPGTD
ADGVTVHVPV SILNRVSPAG FDRMVPGLLD ELCVATIRSL PKAVRRELVP APDVGTAVAD
WIRANTPAWA DMTRAGEMAP PFHVEFTRAV RALRDVVIDD DVWDAERVER LPAHLRMTFR
VEGAPAADTA ANGRPAKGRG RRPGGGRGRG APASSEPVVL GESKDLLSLQ KRFAAQAEAA
VRAAVKGAVG LALDEARAAS SGAPGVTDEA TKVAGAGVGA PPSSRSGGPP GARERGGAPM
AAPATDPTSV VREEAGLTTW PSSLVDGVLP DAVSTDLGGG VVVRGYPALV EEAGAKGSGS
GAAPSVALRV LADVTERDVV HARGVRRLLL SETALATGRV SSRWSGNQAL TLAAAPYRNT
DALVADLQLA AVIALTSPDA DKAPGTPTGG PDAVQIRDAE SYKAALTFVR QHLEDEVHRV
VGHVVAALTA WRTVEGEVRA SSSLALLNTL QDVREHVATL VHAGFVSATP PRRLPHLVRY
LRADSYRLDK AQANPVRDGE LAWRIRDVTG VYEQARATYA AGAPDPARAA ELADVRWLLE
ELRVSLFAQQ LGTDGSVSEK RIRKILSPGG W
//
