ID A0A2A9F6H7_9PSEU Unreviewed; 1195 AA.
AC A0A2A9F6H7;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE RecName: Full=DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00012417};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
GN ORFNames=ATK36_1570 {ECO:0000313|EMBL:PFG46583.1};
OS Amycolatopsis sulphurea.
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Amycolatopsis.
OX NCBI_TaxID=76022 {ECO:0000313|EMBL:PFG46583.1, ECO:0000313|Proteomes:UP000243542};
RN [1] {ECO:0000313|EMBL:PFG46583.1, ECO:0000313|Proteomes:UP000243542}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 46092 {ECO:0000313|EMBL:PFG46583.1,
RC ECO:0000313|Proteomes:UP000243542};
RA Klenk H.-P.;
RT "Sequencing the genomes of 1000 actinobacteria strains.";
RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PFG46583.1}.
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DR EMBL; PDJK01000002; PFG46583.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2A9F6H7; -.
DR Proteomes; UP000243542; Unassembled WGS sequence.
DR GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR CDD; cd04485; DnaE_OBF; 1.
DR CDD; cd12113; PHP_PolIIIA_DnaE3; 1.
DR Gene3D; 1.10.150.870; -; 1.
DR Gene3D; 1.10.10.1600; Bacterial DNA polymerase III alpha subunit, thumb domain; 1.
DR Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR InterPro; IPR011708; DNA_pol3_alpha_NTPase_dom.
DR InterPro; IPR041931; DNA_pol3_alpha_thumb_dom.
DR InterPro; IPR040982; DNA_pol3_finger.
DR InterPro; IPR004805; DnaE2/DnaE/PolC.
DR InterPro; IPR029460; DNAPol_HHH.
DR InterPro; IPR004013; PHP_dom.
DR InterPro; IPR003141; Pol/His_phosphatase_N.
DR InterPro; IPR016195; Pol/histidinol_Pase-like.
DR NCBIfam; TIGR00594; polc; 1.
DR PANTHER; PTHR32294; DNA POLYMERASE III SUBUNIT ALPHA; 1.
DR PANTHER; PTHR32294:SF0; DNA POLYMERASE III SUBUNIT ALPHA; 1.
DR Pfam; PF07733; DNA_pol3_alpha; 1.
DR Pfam; PF17657; DNA_pol3_finger; 1.
DR Pfam; PF14579; HHH_6; 1.
DR Pfam; PF02811; PHP; 1.
DR SMART; SM00481; POLIIIAc; 1.
DR SUPFAM; SSF89550; PHP domain-like; 1.
PE 4: Predicted;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Reference proteome {ECO:0000313|Proteomes:UP000243542};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 7..74
FT /note="Polymerase/histidinol phosphatase N-terminal"
FT /evidence="ECO:0000259|SMART:SM00481"
SQ SEQUENCE 1195 AA; 131270 MW; 64A1E167B318B304 CRC64;
MSNDSFVHLH VHTEYSMLDG AAKIGALFGE ASRLGMSAVG MTDHGNMYGS DEFYQTAQKH
GVKPIIGIEA YVAPESRFHK KPVFWGQASQ RGSDEFGEGG DVSGGGAYTH MTMLAENATG
LRNLFKLSSL ASTQGYYRKP RMDRELIAEN AAGIIATTGC PSGEVQTRLR LGQREAAIQA
ASDYKDIFGA DNFFLELMDH GLPIERSVRE GLLEVGRLLD LRPLATNDSH YVTKDQADTH
SALLCVQAGK TLNDPTRFKF DGDGYFLKSA EEMRAYWDTE VPGAADSTLL IAERVQSYGE
VYAHKDRMPV FDVPDGHDEA SWLRHQVAEG LKWRFPEGVP DGYEDRCDYE LGVIEQKGFP
AYFLIVADLI QHAREVGILV GPGRGSAAGA LVAFALGITN LDPIPQKLLF ERFLNPERMS
MPDIDIDFDD RRRGEMIRYA TEKYGADRVA QVITFGTIKT KAAIKDSARV HFGQPGYSIA
DKISKALPPP IMAKDIPLSG IVDSKHERYA EAAEVRTLVE TDEECKTIFD TARGLEGLIR
NAGVHACAVI MSSEPLTDAI PVWQRDDGSI ITGWDYPSCE NIGLLKMDFL GLRNLTVIGD
ALANIKANRG EEIDLDRLGF DDPEAYRLLG RGDTLGVFQL DGGAMRDLLR RMQPTGFEDI
VAVLALYRPG PMGMNAHNDY ADRKNNRQEV KPIHPQLEEP LREILAETYG LIVYQEQIMQ
IAQKVADYTM GRADTLRRAM GKKKKEVLEK EYEGFEEGMR ASALVSGGFS SEAVKALWDT
ILPFAGYAFN KSHAAAYGLI AYWTAYLKAN YTPEYMAALL TSVGDNKDKS AIYLSECRRL
GIRVLPPDVN ESALRFAAVG NDIRFGLGAV RNVGANVVES VIATREEKGK YSSFIDFLDK
SELVACNKRV LESLIKAGAF DSMGYTRLSI VQVHEDAVEA VVPLKRQEAM GQFDLFGSFG
AEEGAGEAAP SASPLAHLKF GEEEYPRKQL LAYEREMLGL YVSAHPLDGA ERILRKHAPR
SIAALLADPP REGEIVISGL LTSLERRVNK NGEPWAICTV EDMDAALEVL FFAKAYSMFA
ADLVEDNAVL VKGRVNWRED KMSVFGGGLV PLDLSAVGSG GEEPPLVLLA AAEKIDQSVV
SELKSTLLAH KGETPVHLKL VGKNQTVFAL YDYPVKVSSM LIGELKGIRG ITANS
//