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Database: UniProt
Entry: A0A2A9FJY0_9PSEU
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ID   A0A2A9FJY0_9PSEU        Unreviewed;       419 AA.
AC   A0A2A9FJY0;
DT   20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT   20-DEC-2017, sequence version 1.
DT   24-JAN-2024, entry version 22.
DE   RecName: Full=Dephospho-CoA kinase {ECO:0000256|HAMAP-Rule:MF_00376};
DE            EC=2.7.1.24 {ECO:0000256|HAMAP-Rule:MF_00376};
DE   AltName: Full=Dephosphocoenzyme A kinase {ECO:0000256|HAMAP-Rule:MF_00376};
GN   Name=coaE {ECO:0000256|HAMAP-Rule:MF_00376};
GN   ORFNames=ATK36_6008 {ECO:0000313|EMBL:PFG50759.1};
OS   Amycolatopsis sulphurea.
OC   Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC   Pseudonocardiaceae; Amycolatopsis.
OX   NCBI_TaxID=76022 {ECO:0000313|EMBL:PFG50759.1, ECO:0000313|Proteomes:UP000243542};
RN   [1] {ECO:0000313|EMBL:PFG50759.1, ECO:0000313|Proteomes:UP000243542}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 46092 {ECO:0000313|EMBL:PFG50759.1,
RC   ECO:0000313|Proteomes:UP000243542};
RA   Klenk H.-P.;
RT   "Sequencing the genomes of 1000 actinobacteria strains.";
RL   Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the phosphorylation of the 3'-hydroxyl group of
CC       dephosphocoenzyme A to form coenzyme A. {ECO:0000256|HAMAP-
CC       Rule:MF_00376}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=3'-dephospho-CoA + ATP = ADP + CoA + H(+);
CC         Xref=Rhea:RHEA:18245, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:57287, ChEBI:CHEBI:57328, ChEBI:CHEBI:456216;
CC         EC=2.7.1.24; Evidence={ECO:0000256|HAMAP-Rule:MF_00376};
CC   -!- PATHWAY: Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-
CC       pantothenate: step 5/5. {ECO:0000256|HAMAP-Rule:MF_00376}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00376}.
CC   -!- SIMILARITY: Belongs to the CoaE family. {ECO:0000256|HAMAP-
CC       Rule:MF_00376}.
CC   -!- SIMILARITY: In the C-terminal section; belongs to the UPF0157 (GrpB)
CC       family. {ECO:0000256|ARBA:ARBA00011058}.
CC   -!- SIMILARITY: In the N-terminal section; belongs to the CoaE family.
CC       {ECO:0000256|ARBA:ARBA00008826}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PFG50759.1}.
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DR   EMBL; PDJK01000002; PFG50759.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2A9FJY0; -.
DR   UniPathway; UPA00241; UER00356.
DR   Proteomes; UP000243542; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004140; F:dephospho-CoA kinase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0015937; P:coenzyme A biosynthetic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   CDD; cd02022; DPCK; 1.
DR   Gene3D; 3.30.460.10; Beta Polymerase, domain 2; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   HAMAP; MF_00376; Dephospho_CoA_kinase; 1.
DR   InterPro; IPR001977; Depp_CoAkinase.
DR   InterPro; IPR007344; GrpB/CoaE.
DR   InterPro; IPR043519; NT_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   NCBIfam; TIGR00152; dephospho-CoA kinase; 1.
DR   PANTHER; PTHR34822; GRPB DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G01530); 1.
DR   PANTHER; PTHR34822:SF1; GRPB DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G01530); 1.
DR   Pfam; PF01121; CoaE; 1.
DR   Pfam; PF04229; GrpB; 1.
DR   SUPFAM; SSF81301; Nucleotidyltransferase; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51219; DPCK; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW   Rule:MF_00376};
KW   Coenzyme A biosynthesis {ECO:0000256|ARBA:ARBA00022993, ECO:0000256|HAMAP-
KW   Rule:MF_00376}; Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00376};
KW   Kinase {ECO:0000256|HAMAP-Rule:MF_00376, ECO:0000313|EMBL:PFG50759.1};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW   Rule:MF_00376}; Reference proteome {ECO:0000313|Proteomes:UP000243542};
KW   Transferase {ECO:0000256|HAMAP-Rule:MF_00376}.
FT   BINDING         36..41
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_00376"
SQ   SEQUENCE   419 AA;  45465 MW;  1007AE05E625944A CRC64;
     MLVHVQRVPG RSPHGVRGAL VRVWLMLRVG LTGGIGSGKS TVANRLAEHG AVVVDSDRIA
     RAVVEPGTPG LAAIAEAFGT GVLAADGSLD RAALGARAFA DEESRQRLNG ILHPLIGQRT
     GELMAEAAAD AIVVHDVPLL VENDLAPAYH LVVVVDAPVE VRVRRLVEAR GMTEEDARAR
     IRAQATEDQR RAVADVWLDN GGRRDAVLAE VDELWADRLV PFEANLRLRK PRPPASPVLS
     AYDPSWPLQA ERRLARLRQL AGPRLVRADH IGSTAVPGLP AKDVLDLQLT VSTLDDADAL
     AEALADAGFP QREGEWVDDP QDGGTPWPKR LHVGADPKRA VNLHVRSVET PGWRLALLFR
     DWIRAHPGER EDYAAVKQRL AGEHAGDGTV QYYAEAKQGW VNEAFTRAEA WAADSSWKP
//
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