ID A0A2A9G3S8_9PSEU Unreviewed; 3065 AA.
AC A0A2A9G3S8;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE SubName: Full=Non-ribosomal peptide synthase protein (TIGR01720 family)/amino acid adenylation domain-containing protein {ECO:0000313|EMBL:PFG57309.1};
GN ORFNames=ATK36_0883 {ECO:0000313|EMBL:PFG57309.1};
OS Amycolatopsis sulphurea.
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Amycolatopsis.
OX NCBI_TaxID=76022 {ECO:0000313|EMBL:PFG57309.1, ECO:0000313|Proteomes:UP000243542};
RN [1] {ECO:0000313|EMBL:PFG57309.1, ECO:0000313|Proteomes:UP000243542}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 46092 {ECO:0000313|EMBL:PFG57309.1,
RC ECO:0000313|Proteomes:UP000243542};
RA Klenk H.-P.;
RT "Sequencing the genomes of 1000 actinobacteria strains.";
RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PFG57309.1}.
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DR EMBL; PDJK01000001; PFG57309.1; -; Genomic_DNA.
DR Proteomes; UP000243542; Unassembled WGS sequence.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0043604; P:amide biosynthetic process; IEA:UniProt.
DR GO; GO:0019752; P:carboxylic acid metabolic process; IEA:UniProt.
DR GO; GO:0008610; P:lipid biosynthetic process; IEA:UniProt.
DR GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR GO; GO:0044550; P:secondary metabolite biosynthetic process; IEA:UniProt.
DR CDD; cd05930; A_NRPS; 1.
DR CDD; cd17643; A_NRPS_Cytc1-like; 1.
DR CDD; cd19543; DCL_NRPS; 1.
DR CDD; cd19540; LCL_NRPS-like; 1.
DR Gene3D; 3.30.300.30; -; 3.
DR Gene3D; 1.10.1200.10; ACP-like; 2.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 3.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 3.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 3.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR010060; NRPS_synth.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR020802; PKS_thioesterase.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR001031; Thioesterase.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 2.
DR NCBIfam; TIGR01720; NRPS-para261; 1.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 3.
DR Pfam; PF13193; AMP-binding_C; 3.
DR Pfam; PF00668; Condensation; 3.
DR Pfam; PF00550; PP-binding; 3.
DR Pfam; PF00975; Thioesterase; 1.
DR SMART; SM00823; PKS_PP; 3.
DR SMART; SM00824; PKS_TE; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 3.
DR SUPFAM; SSF47336; ACP-like; 3.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 6.
DR PROSITE; PS00455; AMP_BINDING; 1.
DR PROSITE; PS50075; CARRIER; 3.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 3.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000243542}.
FT DOMAIN 246..320
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 1711..1786
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 2727..2802
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 1694..1714
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1781..1800
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3065 AA; 329507 MW; 4A114BDD9B459F9F CRC64;
MRQVWTGGDV VPPSAVRAAL SGPDAPTVVN GYGPTETTVF ATRLPLTAIG PGHGSVPIGR
PLDGKRILLL DDALRPVPPG TAGEIYLAGA GVGQGYLRRP GLTAERFVAD PSGPPGSRMY
RTGDLARWNT DGTLDFAGRS DTQVKLRGFR IETSEVDAVL TAEPGVRQSL TVLREDRPGD
RRLVSYVVPA QDADRLAARL ADRLPAFMVP AAIIALDELP LTRNGKVDRA ALPAPGGHAD
PPPGPKPATA AEETVAALFR DVLGLAEVPV DRSFFRLGGD SIKAIQLAGR ARRAGLDLST
PEIFRTPTVS ELARTLQIQP ARRPTPEDPR AEDPLVPLTP IMHWLRGQGG ALAGFSQSLR
VRVPAGVTEE MLRTIVQALV DRHPMLRLSV SIVDGIWSAE IRPDTEAGFT RVDAGDPDAG
DHEQRARAVL DPTRGRVVEA VWFDAGSDRP GALTLAVHHL VVDGVSWRIL LDDLREIGSA
AREGRPPLPA PAGTSFAHWA RLLAERAQHP SVTGHYRRWK TAAPTHDIAM SKRALDPSTD
TEATRRVQVL TLPPAVSGLL AGRTAEAFGC SLNDLLLTAF ALAVVDRRTE AGTAVLVDLE
GHGREEFAEG LDLTRTVGWF TTLFPTVLDP GVRWREARDE PALLDEAVER VRGTMGAIPD
NGLGYGLLRH LNPQTAPSLA TGRVPQLAFN FLGRFETAEE RDWAAVPGDT VLGSSMPEEL
AMAHCIELNT LLVEQAEGPL LQANWSWAGE VLDTEDVLSL GHRWFEVLTA LTERAADLAT
ASVLPLPPLA QGLLFHSLYD HDGTDPYLVQ FVFTLRGELD TAAMRGALHA LLRRHPQLSA
GIQHSSSGRP VQVVPPEFTV PWTEHEVSSE RDVDRFLDTD RRERFELGKP PLVRAAVLRR
GTDRHVFVLT THHLLLDGWS MPILIRELFA LYAGAALPEA PSYRDFLKWL GARDPEADQA
AWRDLLSDVD GPTLVAGRDR PGSGAVRGRA FFELGAQSSA RIRDAAAEGD LTVSVLVRLA
WATVLGSLTG RDDVLFGATV SGRPPELAGA ENMVGLLINT VPVRVRLDPA RTITETLHAL
REQHLTTLEH QHADLTGLQE LAGHRELFDT AIVFENYPLD ADALRCPAPG LEITGLRGLD
GSHYPLALLV LPGERFGLRL DHDEDLFDHA AAHRLLARFA TILDRIASEP RARLAELDLL
LHDERPGTAA EPAVTETTLP GLFAAQVARR PEATAVVDGE RRLSYRELDE HSTRLAALLR
ARGAGPERLV ALALPRSADA VIGVLAVLKS GAGYVPLDLE HPAQRLNEIL EDTGPVLVVT
TEDAAVPGGR PKLLLDDVAG SVPEDGVAEI SVSAANTAYV IHTSGSTGRP KGVTVSHRTV
VNLLSSTDEL IGAGPEDVHS LFHSLAFDVS VWEMWAALGR GGRLVVVPST VTRSPRELLG
LLAAEGVTVL SQTPSAFYQL MAAEAERPAE LALRMVIFAG EALDPTRIRS WQGPGRPRLV
NLYGITETTV HSTFQEISDP GTTRSVVGTA LPGEQIRLLD HALRPVPPGC PGEIYVAGHG
VTRGYLGRPG LTAQRFVADL FGGPGARMYR SGDLARTLPD GTLEYLGRTD HQVKVRGFRI
EPGEVERRLE KHPAVHRAVV LPHEQDRLVA YAVLRGPVGS GELRAHAAAA LPAHMVPAFV
VPVPEIPLTA NGKLDRRALP DPAPAPSVSR PADTEEERIL CAAFAETLGV AEAGADDSFF
DLGGHSLLAT RLINLIRSRT GIELGIRALF DAPTPAALAA RLSGPGSRRR PALRPGARPD
RVPLSAAQRR LWFFTEFAGP NAVYNMPFSA RLTGELSVKA LREAVSDLLT RHESLRTRVA
DVDGEPCQDL RPAAEADFAV VATTRADLPD RLAEAGAHRF DLGAELPVHV RLFVLGPDEH
VLLFLVHHIA ADGWSFAPLV ADLSAAYRAR LAGGAPQWTD EPIQYADFTL WQNELDLASD
EEFWRETLRG LPQAPSSLPT DHPRPAVSAH RGETISVDFD AGLHTALTGL AKAHGVSLFM
LLHAALATLT SRLGAGGDLA IGTPVAGRHD HALDRAIGCF VNTVVLRSTI DPATPFTEFL
STVRDTDLAA FAHQDLQFDR LVELLNPVRT PGSHPLFQIM LAFQDTPAIR FDLPGIDAEH
LPVRGGGSRL DLLWSLWQRD GGGITGVLEY DAELFRPATA RALTTRFEQL LRAITRAPDT
AIADLDILLP GERRRVLETW NDTAATPPSA TVAEQFAAHV AATPEAPAIL SGGGTTSYRQ
LDDLVRGIAA DLASQGIGPG DLVALQLARG PALPAAMLAV HSLGAAYLPC DRDLPEQRLA
TLLTDSRPAL LLRDEEGTIE FVRPGGRPSL LPADSAYTIY TSGSTGKPKG VLIGHPALAN
LLGALGEQLA VTPSDRMLAC SPTGFDMSVP EFFLPLVSGA AMVLVDRDVS RDPVLLLETV
QRLGVTVLQT TPSLWQALAD LQPRLPGVRA VIGGEAVPDS LAESVRGLGC SLLACYGPTE
TTVWSATLPV GDRTEATVPL GRPLANTRCV VLDAHLHPVP PGVLGHLYIA GDGVATGYLN
QSAQTAQRFV ADPFGGPGAR MYHTGDLASW SSQGILHFHG RSDRQLKLRG HRIEPGEIEA
ALTGHPGVTA AAVTVHEHGP GDHRLVGYLI GDAEIDAVHE YVRRRLPSYM RPSKLLTVDE
FPLSHNGKLQ LDHLPAPRWD IAAEPEPPRN PREQVLCSLF AEVLGLPRVG ASDNFFELGG
HSVLAIRLAA RIGAVLGVDP QIRDVFLAGT PARLAAALDG TGRTGQLVPF RAGGDGTPVF
CVPPLSGISW LYAGLLHHLD RAHPLYGFQD DVPGEELRLP RSVDEMADRY ADLLSSAHPT
GPVHLVGWSF GGVVAHAMAR LLRERGREVG LLLLDPQAGP AQDLLGEPDD ERIHRVLLTA
VGHDDSVFAP GELTAKALFT ILRAENSFFA RYTEDDIRRI VRVSRNNAAL LRGHRPAHYA
GDATLVTTPG TGDSTVDWGV HVGGDLTTHE IDTAHHRLLQ PRNLSRLGDI LRRQLGAAGR
PEETP
//
