ID A0A2A9MHU1_9APIC Unreviewed; 6404 AA.
AC A0A2A9MHU1;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=Type I fatty acid synthase {ECO:0008006|Google:ProtNLM};
GN ORFNames=BESB_051670 {ECO:0000313|EMBL:PFH35516.1};
OS Besnoitia besnoiti.
OC Eukaryota; Sar; Alveolata; Apicomplexa; Conoidasida; Coccidia;
OC Eucoccidiorida; Eimeriorina; Sarcocystidae; Besnoitia.
OX NCBI_TaxID=94643 {ECO:0000313|EMBL:PFH35516.1, ECO:0000313|Proteomes:UP000224006};
RN [1] {ECO:0000313|EMBL:PFH35516.1, ECO:0000313|Proteomes:UP000224006}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bb-Ger1 {ECO:0000313|EMBL:PFH35516.1,
RC ECO:0000313|Proteomes:UP000224006};
RA Schares G., Venepally P., Lorenzi H.A.;
RT "Genome sequencing of Besnoitia besnoiti strain Bb-Ger1.";
RL Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PFH35516.1}.
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DR EMBL; NWUJ01000004; PFH35516.1; -; Genomic_DNA.
DR STRING; 94643.A0A2A9MHU1; -.
DR VEuPathDB; ToxoDB:BESB_051670; -.
DR OrthoDB; 5491581at2759; -.
DR Proteomes; UP000224006; Chromosome iv.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR CDD; cd08955; KR_2_FAS_SDR_x; 1.
DR CDD; cd00833; PKS; 5.
DR Gene3D; 3.40.47.10; -; 5.
DR Gene3D; 1.10.1200.10; ACP-like; 4.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 3.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 3.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 2.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR013120; Far_NAD-bd.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR020807; PKS_DH.
DR InterPro; IPR049551; PKS_DH_C.
DR InterPro; IPR049552; PKS_DH_N.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF37; FATTY ACID SYNTHASE; 1.
DR Pfam; PF00698; Acyl_transf_1; 3.
DR Pfam; PF00109; ketoacyl-synt; 5.
DR Pfam; PF02801; Ketoacyl-synt_C; 5.
DR Pfam; PF08659; KR; 2.
DR Pfam; PF07993; NAD_binding_4; 1.
DR Pfam; PF21089; PKS_DH_N; 1.
DR Pfam; PF00550; PP-binding; 4.
DR Pfam; PF14765; PS-DH; 1.
DR SMART; SM00827; PKS_AT; 3.
DR SMART; SM00826; PKS_DH; 1.
DR SMART; SM00822; PKS_KR; 2.
DR SMART; SM00825; PKS_KS; 5.
DR SMART; SM00823; PKS_PP; 4.
DR SMART; SM01294; PKS_PP_betabranch; 1.
DR SUPFAM; SSF47336; ACP-like; 4.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 3.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 4.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 3.
DR SUPFAM; SSF53901; Thiolase-like; 5.
DR PROSITE; PS50075; CARRIER; 4.
DR PROSITE; PS00606; KS3_1; 4.
DR PROSITE; PS52004; KS3_2; 5.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000224006};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 108..533
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 699..776
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 801..1241
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 1977..2053
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 2075..2507
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 3790..3866
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 3892..4324
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 5277..5354
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 5375..5825
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT REGION 85..105
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 641..698
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 6384..6404
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 87..105
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 658..698
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 6404 AA; 693995 MW; 8CFBFC3616083A22 CRC64;
MTTIPQVVLS CLENVIVSER GETTYHCGNA EYLFSIAHSD TITFGAFLNR LSATLQVPIG
LLSAAPNESF GAFVVHVEGL ITERTNGERT PLRQTPTQAE SSPSQDVRAD VAIVGVACRL
PGHANTPGDF WAVLAEGKDA IVPIPSERWS REDFIDGHSE RGTMYVEEGG FISGIEEFDN
GFFRISSSEA RRMDPQQRML LELSHEALQF VDRDSYKNNP HRIGVFVGCS SSEWTILKTK
QMERLCAFQT ANTPQALLAN RLSYAFNACG PSLTVDSASS SALVAVSVAA SHIETGQCDA
CLVGSSSLML VPEPTLALCA AGMLAIDSRC RPFDAAANGY GRGEGAVVFL LERWDYQPHG
RPRQKSLATI RGHRTNHNGH IVSVTAPSDV AQRKLLQGVL EEAKVEPGQI AYLEAHGTGT
KLGDTIEFRA IKSVFASSRT AENPLLVGSG KSNVGHLEGC AGAVGLLKAL LVLYFRVVPP
TLHFKQINPL IDDEDFCYQI TTTKVPLDGD QSILAAVSSF GLGGCNAHMI IESSPKDRAI
DAHALSRRHA WEHVRFPVFE SNENNNAFGG LGLRHSAEPA SGIRQCRRRC SASSFFDQQH
LTPVSTRLRR FTAFSSDCGT PLHGVQQLGT KDDYSLETDL HEGRKPAQAV SLDEGNAHEE
APSFHHMPPS QDENEERVTS DTPNQETERD MLSCDRDDDV DEDLVRSMVL ETARQVLKES
KPIQSNISLK ALGLDSLASV EFRDALQESL GITLPASLAF DFPTVDEVCS FLVRKINSEG
INEPPLTTAI VAIDGYCAGH TPSVAVKGMA CRFPGAENGQ TNHFWKTLLS YADCIDEIPA
SRFDISPIFD ADFDARGMIY VREAGILRSA EMFDNTFFEI SDTEVWHLDP RQRILLEVAY
DALMDSRILG VTGIPSLRTK AVGVVVGCSG NDWNTLLQHQ MLPSSSYSGP GTSPALLSNR
VSYTLGLQGP SITIDTACSS SLVAMDIARQ LLISSQCGIA IVGGVQLLLT AETFIHYCSA
RMLSPDCRCK TFDAGANGYV RAEGCGVVVL EKTGEKRTLN GHTYGWLSGT ANNHVGRSAS
LTAPNGPAQQ AVILASLRST QISTPASIHM VETHGTGTAL GDPIEVGALQ AVYGQGTSAD
APLVLGALKS RIGHTEGAAG IAGFIKLICS LRYRVAPPNL HLKQFNPHID ISTTDAARPF
LFPTKPYRLD TLMGGQKGTS LFGAVSSFGF GGSNAHAIVE VPTLEDVLSD EAQHSGLGGA
ENAHEPQPMV WLFTGQGSQY VDMAKSLYET EEVFRRTVTE CSAYLAAENL MPEGGPSSLE
EVIYPKAGSS VAAEELLTLT QYSQVAIFVV ELAITRVLTE RGLRPAVVLG HSLGEYAAAV
AAGVFAWRDA LRIVSARARI MSQQPPQDGV MAACRLSAAQ VQAALTSELK ALRSVAVAAD
NGPQSIVVSG SRSEVEEVLS FFSVSGKARF LKVSHAFHSP LMAGAVEAVR ELFDGVELSR
PSIPFSSTVL GRVVVDDELG DSSYWAEQIV RPVMLYEAVR SIDRLQNGAR LHFVEVGPRP
VLLSLARSCF ELARAAEQCW SYCVNDSSSR EGTNRLFQAI TSGSQENAPA TRHVWNHKYF
PWTTGHPLLG KQRRGDTETH GTRFFYTSVP LGLAEVFHEY AGGSVPTLPA AAILDAMVVA
ARLVTLGDSQ NDGSSGCPIQ LKNFRAHRDM ILPPRAARDT QRALTLCFRI KSDLGRQKIS
CFGNYGNCFV YGDGQEDWLP IADAEITRVP FVRNESSIPF NDLQHRFLHS QDVDRTVSMR
REHHGTKQDS PSRGMTIRAV YGRGDEVLAH LSRPRIAAED GFILSPAILG ELFRITEALV
KAQAPFQQDN VFSVSGAETV TSLLISRQMC DSIWGHVRIL PLAPGDVQRR VADVTMYNEA
GQPTMQLLAV RLRATGHAEF RREIDRQQNF IRSSGQQRRN LEQRHCQRDW IPSRKTFSPT
QLVGLIRQAC QRVIGANREM DVHTSFQQLG VDSLGAIALR DALEDALHLK LPATTFFDYP
NMHALSDFIA TQVGGIAEET GISSVCSPLR FERPDGAVAV VGVACRLPGS SNNPADFWEM
LMSSADCISE VPPTRFDVEQ FFDIDQRGKG KMYVREGGFI DRVTLFDNHF FGISAAEAQE
MDPRQRICME VATETLRDAR MDHTIVGSNT LVAVGKTNTD SVRVSYRHLS PFSCSGANNS
ILSNRISYFF GTKGPSMTID AACASSLIAI VAGFNELRRG GCTTALAIGV NLLLSPECYI
EICKATMLSP DCRCKTFDAS ANGYVRSEGC CGILLKAIEP ATAVEASGVY AWLRGATTNH
VGRSASLTAP SGPAQQALMR DAIRTSRLQN TENIFAIETH GTGTALGDPI EVGALQAVYG
QGTSADAPLV LGALKSRIGH TEGAAGIAGF IKLICSLRYR VAPPNLHLKQ FNPHIDISTT
DAARPFLFPT KPYRLDTLMG GQKGTSLFGA VSSFGFGGSN AHAIVEVPTL EDVLSDEAQH
SGLGGAENAH EPQPMVWLFT GQGSQYVDMA KSLYETEEVF RRTVTECSAY LAAENLMPEG
GPSSLEEVIY PKAGSSVAAE ELLTLTQYSQ VAIFVVELAI TRVLTERGLR PAVVLGHSLG
EYAAAVAAGV FAWRDALRIV SARARIMSQQ PPQDGVMAAC RLSAAQVQAA LTSELKALRS
VAVAADNGPQ SIVVSGSRSE VEEVLSFFSV SGKARFLKVS HAFHSPLMAG AVEAVRELFD
GVELSRPSIP FSSTVLGRVV VDDELGDSSY WAEQITQPVR FREAVEAAVA LELGRSRAFV
EVGPNRVLAV LGRNCVSETR ATDGDWLSIV DSKSDSSPAD VIALLQERFG QLQTHVAKAR
HMWNHSAFPW TVPRHPLIGG EASAHSERQG ATTYRSRVRY DVLNALCDHV ILGAPLMPGA
AFIDAILAAG RLAATKSGTR LTSPSIVTLT DVSIFSPLLL RDSVSRAAPL SKEGFQLSSL
ELSVEMSSSG GGHLVEVRSR QADDVPAAAN DDSTQAHCRG QLAVSSGGIR PSEQAGSTLA
DVRRRFSSQV ACDVEALYQT FADLGWQYGV LFRVITQLYR TDTEALAELR LPRPLLPSEE
GFVVHPAILD GLFQAAGSLL LADDKTPAGS VYVPVGIDNV VLAPKALRRD VVWGRVAVAE
KDREARQRHE RVLDCTLYDG NGEAVLYLNG LRSRLLRTEV LLSAQTNGIS SNRLWSLEWT
AIEAPAHLPP ISGGKAETAW LVAGVQPPLK SMVEELLCRA LPAAKIIFCK SLSQMSTMEA
RNTLQQETWD TIIHLGGTTS STSEMECLND VLALVQGLTD WVGSDSGPAK LPSIFLVTRG
ADSHVAASPS VPVARPPVHT GVRGLFRTAK VELEALWNRF VPFHYIDVEP VSEAPDITPD
ELRRLIPVVQ QLGTESQAIE SKLGEGLSGA SLYESETILR GSERLLPRLV PFRPVESGDN
NALAEALLGT IVITGGLGGI GLVVAKWLAD RGAKAIVLVS RTGSPSADVQ QSEEWQSFQA
RQGAARIATA RCDVGDLEQV KLLFRSLRDG EFVCLRTGQT QDLPPVRGVM HAAGVLKDCP
IHKQDRETLA SVFQPKAQGG WNIHFALEEL GMSEDIAVFL GFSSIASLVG NPGQANYAAA
NSSLDALISY RRGRGLPGHS IQWGPWTEQG MAAGLRDRLE RAGFVGISNE VGVETVGAIV
SQGKAGNPVI ACQQFNWARF ALRYRGCLPA MFKEQTQSVT VRGREERVSK QLSGPGAAAE
GVFTSMSDEE LKTFIQTTVA GAARQVLGRG EDPPPDVPLQ DLGIDSLGAV EFRNTLQDLL
GLKLSATILF DHPTLRALTT FLSSRLESER SPESSSSSLA NAVPAPLAGH QRADIAVVGM
ACRLPGSVSD PESFWKMLLT LRDCIQEIPP SRFSIDDVYD PDPDAKGKIY VREGGFIDGA
ELFDNRYFGI SDAEAREMDP RQRVSLEVSY EAFIDAGYSR EELYGSPVGV FVGAMNHDKL
YDDLRQLGSY SGTSNALAIL SNRLSYTFGL TGPSIVIDTA CSSSLVALDL ARLDLCYGSS
GFRLVLGVNL MPTVDPYIQC CKARMLSSEC RCKTFDADAN GYVRSEGCAA VLLQQRTSRA
SSKHAPYALL RGTANNHVGR SASITAPNGP AQQAVIRAAL DSGRHIPPWS MALLETHGTG
TALGDPIEVG ALQAVYGQGT SADAPLVLGA LKSRIGHTEG AAGIAGFIKL ICSLRHRVAP
PNLHLKQFNP HIDISTTAAA RPFLFPTKPY RLDTLMGGQK GTSLFGAVSS FGFGGSNAHA
IVEVPTLEDV LSDEAQHSGL GGAENAHEPQ PMVWLFTGQG SQYVDMAKSL YETEEVFRRT
VTECSAYLAA ENLMPEGGPS SLEEVIYPKA GSSVAAEELL TLTQYSQVAI FVVELAITRV
LTERGLRPAV VLGHSLGEYA AAVAAGVFAW RDALRIVSAR ARIMSQQPPQ DGVMAACRLS
AAQVQAALTS ELKALRSVAV AADNGPQSIV VSGSRSEVEE VLSFFSVSGK ARFLKVSHAF
HSPLMAGAVE AVRELFDGVE LSRPSIPFSS TVLGRVVVDD ELGDSSYWAE QVTQPVRFRE
ATLAAFSLLP SCLIGIEVGP KPTLARLVPS CLGADKSATC TWVCVCDESV TSGSGYPVKD
FEHRLEALRV CKVQWNHRSF PLSRMTNGRT QHLDARSNTN AQVLQQRRSH LWREEWVYHS
GIVEYHKASA VAKEAWIIAG VPPQHVTGML QYLKMMKMDT SRVVGMGAIS TLESLRALVQ
GGKWAGILSV SGIWTTTPAV DCLMETTDIL RHYGKLSQEL DLPPLAVVTR GAQCAIISEE
ESRRGNRNAC DRETQTICAD HHTYRDAPVH SGMMAFCRTA RLELERCCNK FRSLLYFDLD
WNRSRETEDR HGLHLDSVLG WLMRTGTPSP HTEINPTSAV SPYEGDIIIR GQSYFVPRAA
AVLLKSPSVA GAGMIDSTKS YIVTGGLGGI GVAVACWLVR RGAGKVYVWS RSGSVKEDVK
QSDYWSELNA AVEGGKIETV RCDVSVVDQV RVSFSTAITG SPLGGIFHCA GTEGKDKLQD
LSKQDIVAVY GSKVEGAWNL HRVCQEMSVG RHLDFFVLFS SIAALPGNDA FAVYAAANCC
LDNLAEYRRS LSLPAQSIQW GPWLDVGMAA RTASLERFMR TRGIQGFHSE EAISVLEDLL
AARGILVSTA AVQIDWRLYA HIFGSRVPAW LLGVVPDLVE PLQGTSAAVT AAPSVSSLGL
QKVEAAVIEV ARRMSGASDA VTATTEISSL GLDSLGAVEF RNALQETLNV KLPASLLVEY
PSLNNIIEFI LESATGDGNL VDDANFVIPK PSMVDDGFAV VGMGCRIPNN AVTPEAFWDM
LLNEVDAVHE IPMDRFNMDA FYDPDPEQDK CYTRDAALLD SPDVFDNAFF NLSEKEVLAI
DPQQCMLLEV AYEAFFEAGF TKSALMGKDF GVFCAAYNND FQFTNLTQGK ATMCVLDEGE
GRRRIPSLGE AAGYPEPGGF MCFIPNRISY SFGLTGPSIG IDAACASALV AFDAAVTKLK
RRACSGALIG GVNIILSPTF FLGGCRAHQF SRAGRCKTFD CHADGLVRGE GCGAVCVLPL
AAARDSGSFI HAVVRGSASC HYGRSSLITS PNTRALTRVL RLALEDAGAE ASSVRYYEAH
GTATVLGDVI EMSAVRDVFQ TNRTAAAPLH LGTVHNNIGH LDAAAGIVAF IKTVLCLQHR
FVPANIHFTS LHPDIQGIDP HLIKYTRESQ EIITEPHSDD APRTLLGANL AYGMGGSVAA
VITEAGDDVT ARQPGSAPRR PKWNHRRFPL NTQKFIFLMG AMGQLSMDDM PTPQSDVVNV
MNRLSDTILN VTFMRQLRSP RCGAARMRSV FVTGATGFIG SQLLFHLLQA RCGDLELGEE
RGKLQIYCLV RARDRAHALY RIKDAFVGRG IEWDPDYNRR VIPVVGDLEE NENMGLGVRQ
LDFLTRVIDA VYHAADNVNF AAPYDELRKT NVTSLIGILK LCTTFVAKPL HLISNFSHHL
QYFAAFSNDL NIPVEETISP PLKPDMVKRL EQQMPAGIVG YPWTKWAVEE IVGRMKDVLQ
HRCKEDSVDK PDTDAILSKF QVVVYRLPNS CVYYRNGYTN FGNASLALVL ACAQERMLPP
GVPPVGAPFL TTPVDLTTEI VVKLSMTKER QHDVYHLVSL RAARRDNILQ VAKWLFSDIS
ECTVDELLRR VDANKENSPA HNLRAAMRFW RSYWYCPDTD RENAFPIMTG HIEDDIPGIT
TAFPHLADTW IRMAAYCVKN YHMVRHPFTL AIPFDILKKA IQEMERRWGH LPSLPRHTEF
LLKEASSTED CSDIAAAKAL AEHSGSTAPD CCVSSEVPDP RARA
//
